[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601213":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":34,"locations":42,"responsibleParty":58,"collaborators":25,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":25,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":80,"overallStatus":45,"whyStopped":25,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Medical University Innsbruck","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"PCD-CT-Guided Diagnostic Strategy","EXPERIMENTAL","Participants randomized to this arm will undergo coronary artery disease (CAD) assessment using photon-counting detector computed tomography (PCD-CT). Invasive coronary angiography (ICA) will only be performed if PCD-CT shows significant CAD, defined as ≥70% diameter stenosis in vessels ≥2.5 mm or ≥50% in the left main artery.",[13],"Diagnostic Test: PCD-CT-Guided Diagnostic Strategy",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard Invasive Coronary Angiography","ACTIVE_COMPARATOR","Participants randomized to this arm will undergo routine invasive coronary angiography (ICA) as the standard of care for pre-TAVR assessment of coronary artery disease.",[19],"Diagnostic Test: Standard Invasive Coronary Angiography",[21,26],{"type":22,"name":15,"description":23,"armGroupLabels":24,"otherNames":25},"DIAGNOSTIC_TEST","Standard invasive coronary angiography performed routinely for all participants in this arm to assess coronary artery disease before TAVR.",[15],null,{"type":22,"name":9,"description":11,"armGroupLabels":27,"otherNames":25},[9],[29,32],{"name":30,"affiliation":5,"role":31},"Sebastian J Reinstadler, MD, PhD","PRINCIPAL_INVESTIGATOR",{"name":33,"affiliation":5,"role":31},"Martin Reindl, MD, PhD",[35,39],{"name":30,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","+43 512 504 25665","sebastian.reinstadler@tirol-kliniken.at",{"name":40,"role":36,"phone":37,"phoneExt":25,"email":41},"Ivan Lechner, MD, PhD","ivan.lechner@tirol-kliniken.at",[43],{"facility":44,"status":45,"city":46,"state":25,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Medical University of Innsbruck","RECRUITING","Innsbruck","6020","Austria","AT",{"type":51,"coordinates":52},"Point",[53,54],11.39454,47.26266,{"lat":54,"lon":53},[57],{"name":30,"role":36,"phone":37,"phoneExt":25,"email":38},{"type":59,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100601213","assessment-of-coronary-artery-disease-before-transcatheter-aortic-valve-replacement-a-randomized-multicenter-non-inferiority-trial-100601213",false,"NCT07107568","Assessment of Coronary Artery Disease Before Transcatheter Aortic Valve Replacement: A Randomized, Multicenter, Non-Inferiority Trial","TAVR-CT","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Severe aortic valve stenosis and indication for intervention according to current European Society of Cardiology (ESC) guidelines\n* TAVR candidate\n* Written informed consent\n\nExclusion Criteria:\n\n* Cardiogenic shock at presentation (e.g., emergency indication for TAVR)\n* Severe renal impairment with an estimated glomerular filtration rate of \\\u003C30 mL\u002Fmin\u002F1.73 m²\n* Life expectancy \\\u003C1 year due to other severe non-cardiac disease (e.g., malignancy)\n* Pregnancy","ALL","18 Years",{"count":70,"type":71},700,"ESTIMATED","INTERVENTIONAL",[74],"NA","The goal of this clinical trial is to determine whether a non-invasive coronary assessment strategy using photon-counting detector computed tomography (PCD-CT) is non-inferior to invasive coronary angiography (ICA) for evaluating coronary artery disease (CAD) prior to transcatheter aortic valve replacement (TAVR) in patients with severe aortic stenosis.",[77,78,79],"Aortic Valve Stenosis and Insufficiency","Coronary Artery Disease(CAD)","Transcatheter Aortic Valve Replacement (TAVR)",[65,81,82,83,84,85,86],"PCD-CT","Severe Aortic Stenosis","Transcatheter Aortic Valve Replacement","TAVR","Photon-Counting Detector CT","Randomized Controlled Trial","2025-08-18",{"date":89,"type":90},"2025-08-22","ACTUAL",{"date":92,"type":90},"2025-08-14",{"date":94,"type":71},"2029-12-31",{"name":5,"class":6},1]