[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100550915":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":49,"centralContacts":54,"locations":60,"responsibleParty":88,"collaborators":58,"id":90,"slug":91,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":98,"sex":99,"minAge":100,"maxAge":101,"enrollmentInfo":102,"targetDuration":58,"studyType":105,"phases":106,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":62,"whyStopped":58,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Iffat Anwar Medical Complex","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Conventional Therapy Group","EXPERIMENTAL","* Intervention: Participants will receive standard treatment for CLBP, including NSAIDs and physical therapy.\n* Frequency: Daily NSAID use as prescribed, physical therapy sessions twice a week",[13,14],"Drug: NSAIDs (Nonsteroidal Anti-Inflammatory Drugs):","Procedure: Standard Physical Therapy",{"label":16,"type":10,"description":17,"interventionNames":18},"Neuromodulation + PRP Therapy Group","* Intervention: Participants will undergo neuromodulation via the DRG and receive PRP injections.\n* Frequency: Neuromodulation sessions once a week for the first month, followed by monthly maintenance sessions if needed. PRP injections will be administered once a week for the first three weeks.",[19,20],"Procedure: Neuromodulation via Dorsal Root Ganglion (DRG):","Procedure: Platelet-Rich-Plasma Therapy",[22,30,37,43],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DRUG","NSAIDs (Nonsteroidal Anti-Inflammatory Drugs):","Objective: To reduce pain and inflammation associated with chronic low back pain.\n\nMedications: Ibuprofen, Naproxen, or Diclofenac.\n\nDosage:\n\nIbuprofen: 400-600 mg every 6-8 hours as needed. Naproxen: 250-500 mg twice daily as needed. Diclofenac: 50 mg three times daily as needed. Administration: Oral tablets. Duration: Daily use as prescribed, for the duration of the study. Monitoring: Regular follow-up visits to monitor pain levels, side effects, and adherence.",[9],[28,29],"Ibuprofen","Naproxin",{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"PROCEDURE","Standard Physical Therapy","Objective: To improve mobility, strength, and reduce pain.\n\nTechniques:\n\nStretching exercises. Strengthening exercises for core and back muscles. Manual therapy techniques. Postural training. Frequency: Twice a week sessions. Duration: 45-60 minutes per session. Monitoring: Progress will be assessed during each session and adjusted as necessary",[9],[36],"Muscle strengthening",{"type":31,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"Neuromodulation via Dorsal Root Ganglion (DRG):","Objective: To modulate excitatory pathways and reduce pain through targeted stimulation.\n\nProcedure:\n\nPlacement of electrodes near the DRG. Application of pulsed radiofrequency (RF) at 42°C for 3-20 minutes.\n\nFrequency:\n\nInitial treatment: Once a week for the first month. Maintenance: Monthly sessions if needed. Duration: Each session lasts approximately 30-45 minutes. Monitoring: Pain levels and functional improvement will be assessed before and after each session.",[16],[42],"Pulsed RF",{"type":31,"name":44,"description":45,"armGroupLabels":46,"otherNames":47},"Platelet-Rich-Plasma Therapy","Objective: To promote healing and reduce inflammation through the application of concentrated platelets.\n\nProcedure:\n\nBlood draw from the patient. Centrifugation to separate platelets. Injection of PRP into the affected area of the lower back.\n\nFrequency:\n\nInitial treatment: Once a week for the first three weeks. Follow-up: Additional injections may be given based on patient response and clinical judgment.\n\nDuration: Each session lasts approximately 30-45 minutes. Monitoring: Pain levels, inflammation markers, and functional improvement will be assessed before and after each injection.",[16],[48],"platelet concentrates",[50],{"name":51,"affiliation":52,"role":53},"Shahzad Anwar, MBBS, DOM","Iffat Anwar Medical Complex, Lahore","PRINCIPAL_INVESTIGATOR",[55],{"name":51,"role":56,"phone":57,"phoneExt":58,"email":59},"CONTACT","+923009400049",null,"shahzadtirmzi@yahoo.com",[61],{"facility":5,"status":62,"city":63,"state":58,"zip":58,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":71,"contacts":72},"RECRUITING","Lahore","Pakistan","PK",{"type":67,"coordinates":68},"Point",[69,70],74.35071,31.558,{"lat":70,"lon":69},[73,76,77,80,82,84,86],{"name":74,"role":56,"phone":75,"phoneExt":58,"email":59},"Shahzad Anwar, MBBS,DOM","03009400049",{"name":74,"role":53,"phone":58,"phoneExt":58,"email":58},{"name":78,"role":79,"phone":58,"phoneExt":58,"email":58},"Muhammad Waseem Hassan, MBBS","SUB_INVESTIGATOR",{"name":81,"role":79,"phone":58,"phoneExt":58,"email":58},"Muhammad Umar Saeed, MBBS",{"name":83,"role":79,"phone":58,"phoneExt":58,"email":58},"Fatima Tirmzi, MBBS",{"name":85,"role":79,"phone":58,"phoneExt":58,"email":58},"Gull a Rukh, MS",{"name":87,"role":79,"phone":58,"phoneExt":58,"email":58},"Sulayman Waquar, Ph.D,M.Phil",{"type":89,"investigatorFullName":58,"investigatorTitle":58,"investigatorAffiliation":58,"oldNameTitle":58,"oldOrganization":58},"SPONSOR","100550915","assessment-of-different-clinical-techniques-to-treat-patients-with-chronic-low-back-pain-100550915",false,"NCT06453291","Assessment of Different Clinical Techniques to Treat Patients With Chronic Low Back Pain","Innovative Approaches in Managing Chronic Low Back Pain: A Comparative Assessment of Clinical Techniques","CLBP","Inclusion Criteria:\n\n* Adults aged 40-60 years.\n* Diagnosed with chronic low back pain persisting for more than three months.\n* Willingness to participate and comply with study procedures.\n* Ability to provide informed consent.\n\nExclusion Criteria:\n\n* Comorbidities.\n* Contagious and Non-Contagious Infections\n* Known hypersensitivity to study interventions.\n* Presence of severe psychiatric disorders.\n* Pregnancy or breastfeeding.\n* Participation in another clinical trial within the last 30 days.",true,"ALL","40 Years","60 Years",{"count":103,"type":104},100,"ESTIMATED","INTERVENTIONAL",[107],"NA","This clinical trial aims to assess the effectiveness of different clinical techniques in treating patients with chronic low back pain (CLBP). Two test groups will be included: one receiving conventional therapy (NSAIDs and other physical therapy techniques) and the other receiving a combination of neuromodulation and platelet-rich plasma (PRP) therapy. Chronic pain, persisting for more than three months, inhibits natural pathways like GABA and promotes excitatory pathways, leading to increased inflammation. The study hypothesizes that neuromodulation via the dorsal root ganglion (DRG) and PRP therapy will provide superior pain relief and functional improvement compared to conventional therapy.",[110],"Chronic Low Back Pain (CLBP)",[96,112,113],"Neuromodulation","PRP","2024-09-02",{"date":116,"type":117},"2024-09-04","ACTUAL",{"date":119,"type":117},"2024-07-10",{"date":121,"type":104},"2025-05",{"name":5,"class":6},1]