[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100406926":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":37,"locations":43,"responsibleParty":61,"collaborators":41,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":41,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":41,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":46,"whyStopped":41,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Peking Union Medical College Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"conventional myotomy","ACTIVE_COMPARATOR","conventional myotomy for achalasia type I or II",[13],"Procedure: conventional myotomy",{"label":15,"type":16,"description":17,"interventionNames":18},"full-thickness myotomy","EXPERIMENTAL","modified myotomy (full-thickness myotomy) for achalasia type I or II",[19],"Procedure: full-thickness myotomy",[21,28],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","1. Initial mucosal incision. After submucosal injection, a reverse T entry incision is made at approximately 10 cm proximal to the gastroesophageal junction (GEJ).\n2. Submucosal tunnel establishment. A submucosal tunnel is created to 2-3 cm distal to the GEJ.\n3. Endoscopic myotomy. A selective circular muscle myotomy is carried out in a proximal to distal direction, from 2 cm distal to the mucosal entry down to 2 cm distal to the GEJ.\n4. Zippered closure of mucosal entry. The mucosal incision is closed using hemostatic clips.",[9],[26,27],"circular myotomy","non-tailored myotomy",{"type":22,"name":15,"description":29,"armGroupLabels":30,"otherNames":31},"1. Initial mucosal incision. After submucosal injection, a reverse T entry incision is made at approximately 10 cm proximal to the gastroesophageal junction (GEJ).\n2. Submucosal tunnel establishment. A submucosal tunnel is created to 2-3 cm distal to the GEJ.\n3. Endoscopic myotomy. A selective circular muscle myotomy is carried out in a proximal to distal direction, from 2 cm distal to the mucosal entry down to 4 cm proximal to the GEJ, and a full-thickness muscle myotomy is continually carried out from 4cm proximal to the GEJ down to 2 cm distal to the GEJ.\n4. Zippered closure of mucosal entry. The mucosal incision is closed using hemostatic clips.",[15],[32],"modified myotomy",[34],{"name":35,"affiliation":5,"role":36},"Tao Guo, MD","PRINCIPAL_INVESTIGATOR",[38],{"name":35,"role":39,"phone":40,"phoneExt":41,"email":42},"CONTACT","8610-69155017",null,"guoqiong990@126.com",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Department of Gastroenterology, Peking Union Medical College Hospital","RECRUITING","Beijing","Beijing Municipality","100730","China","CN",{"type":53,"coordinates":54},"Point",[55,56],116.39723,39.9075,{"lat":56,"lon":55},[59,60],{"name":35,"role":39,"phone":40,"phoneExt":41,"email":42},{"name":35,"role":36,"phone":41,"phoneExt":41,"email":41},{"type":36,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":41,"oldOrganization":41},"Tao Guo","Associated professor","100406926","assessment-of-different-modified-poem-for-achalasia-100406926",false,"NCT04578769","Assessment of Different Modified POEM for Achalasia","Comparison Study of Conventional Peroral Endoscopic Myotomy (POEM) and Different Modified Procedures of POEM for Achalasia","Inclusion Criteria:\n\n* diagnosed as achalasia type I or II according to the Chicago Classification Version 4.0, with an Eckardt score \\>3\n* Their age is ≥14years and ≤70 years\n* Able to give written consent\n\nExclusion Criteria:\n\n* undergone previous surgical treatments\n* had contra-indication to general anesthesia\n* previous surgery of the mediastinum, stomach, or esophagus;\n* Pregnant or lactating female\n* type III achalasia\n* current alcohol or drug addiction, mental retardation, severe congenital or acquired coagulopathy (international normalized ratio \\>1.6)\n* hepatic cirrhosis with or without portal hypertension, eosinophilic esophagitis (biopsies were performed at index endoscopy), or confirmed Barrett's esophagus\n* esophageal diverticula or hiatal hernia based on findings from the index barium esophagram, or other conditions that the investigator believed not appropriate for POEM procedure","ALL","14 Years","70 Years",{"count":75,"type":76},52,"ESTIMATED","INTERVENTIONAL",[79],"NA","The aims of this study is to compare the efficacy and safety of conventional myotomy (circular myotomy) and modified myotomy (full-thickness myotomy) in the treatment of achalasia patients.",[82],"Esophageal Achalasia",[84,85,86],"peroral endoscopic myotomy","Achalasia","thickness of myotomy","2025-12-03",{"date":89,"type":90},"2025-12-10","ACTUAL",{"date":92,"type":90},"2020-09-02",{"date":94,"type":76},"2026-05-30",{"name":5,"class":6},1]