[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605210":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":23,"locations":29,"responsibleParty":50,"collaborators":53,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":10,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":10,"maxAge":65,"enrollmentInfo":66,"targetDuration":10,"studyType":69,"phases":10,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Centre Hospitalier Universitaire de Liege","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Neurofilament sampling in late preterm newborns",null,"Late preterm infants (34-37 weeks of gestation) admitted to the neonatal unit. Up to 1 mL of additional blood will be collected during routine clinically indicated blood draws at birth, day 2, and weekly until 37 weeks of gestation. Samples will be analyzed for neurofilament concentrations. No independent venipuncture will be performed.",[13],"Other: Blood sampling for neurofilament analysis",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Blood sampling for neurofilament analysis","An additional blood sample (maximum 1 mL) is collected during routine clinically indicated blood draws in late preterm infants (34-37 weeks of gestation). Samples are obtained at birth, day 2, and weekly until 37 weeks of gestation if blood draws are already planned. No separate venipuncture is performed. Samples are processed and stored for subsequent neurofilament concentration analysis.",[9],[20],{"name":21,"affiliation":5,"role":22},"Laurent Servais, MD, PhD","PRINCIPAL_INVESTIGATOR",[24],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Tamara Dangouloff, PhD","CONTACT","+33662438138","tamara.dangouloff@uliege.be",[30],{"facility":31,"status":32,"city":33,"state":10,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Hopital Citadelle","RECRUITING","Liège","4000","Belgium","BE",{"type":38,"coordinates":39},"Point",[40,41],5.56749,50.63373,{"lat":41,"lon":40},[44,46,49],{"name":25,"role":26,"phone":45,"phoneExt":10,"email":28},"0033662438138",{"name":47,"role":26,"phone":10,"phoneExt":10,"email":48},"Marie Machiels","marie.machiels@student.uliege.be",{"name":21,"role":22,"phone":10,"phoneExt":10,"email":10},{"type":22,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Laurent Servais","Principal Investigator, Pediatrician",[54],{"name":55,"class":6},"Centre Hospitalier Régional de la Citadelle","100605210","assessment-of-neurofilaments-levels-in-premature-newborns-study-of-their-early-development-100605210",false,"NCT07159555","Assessment of Neurofilaments Levels in Premature Newborns: Study of Their Early Development","Neurofilaments Levels in Premature Newborns","Inclusion Criteria:\n\n* Gestational age between 34 and 37 weeks of amenorrhea.\n* Blood test scheduled for clinical reasons.\n* Signed parental consent.\n\nExclusion Criteria:\n\n* Known neurological disorders.\n* Severe congenital malformations.\n* Medical contraindication to blood sampling.",true,"ALL","3 Weeks",{"count":67,"type":68},15,"ESTIMATED","OBSERVATIONAL","This is a prospective observational study aiming to establish reference values of neurofilaments in late preterm newborns (34-37 weeks of gestation) and to evaluate their early postnatal evolution.\n\nNeurofilaments are neuronal proteins released into the blood when nerve cells are damaged. They have emerged as promising biomarkers in neurodegenerative diseases, particularly in spinal muscular atrophy (SMA), where higher levels are associated with disease activity. However, very limited data exist on the normal dynamics of neurofilament levels in preterm infants.\n\nIn this study, up to 15 preterm newborns hospitalized in the neonatal unit will be enrolled (5 at 34 weeks, 5 at 35 weeks, 5 at 36 weeks of gestation). A maximum of 1 mL of additional blood will be collected only during routine clinically indicated blood draws, at birth, on day 2, and weekly until 37 weeks of gestation. Samples will be analyzed for neurofilament concentrations and compared across gestational ages, over time, and with existing data from term newborns and SMA patients.\n\nThe expected outcome is to generate normative data on neurofilament levels in late preterm infants, which will help interpret biomarker values in future studies and optimize early diagnosis and treatment strategies for neurodegenerative diseases such as SMA.",[72],"Healthy Participants",[72,74,75],"Neurofilament","Premature infant","2025-12-11",{"date":78,"type":79},"2025-12-12","ACTUAL",{"date":81,"type":79},"2025-12-01",{"date":83,"type":68},"2026-12-31",{"name":5,"class":6},1]