[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100576758":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":12,"centralContacts":24,"locations":31,"responsibleParty":53,"collaborators":12,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":12,"eligibilityCriteria":61,"healthyVolunteers":58,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":12,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":34,"whyStopped":12,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Cairo University","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy Control","NO_INTERVENTION","Systemically healthy patient",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Periodontitis Stage III and IV","ACTIVE_COMPARATOR","Professional mechanical plaque control",[18],"Procedure: Professional mechanical plaque control",[20],{"type":21,"name":16,"description":22,"armGroupLabels":23,"otherNames":12},"PROCEDURE","thisThe first step in therapy is aimed at guiding behavior change by motivating the patient to undertake successful removal of supragingival dental biofilm and risk factor control and may include the following interventions:\n\n* Interventions to improve the effectiveness of oral hygiene \\[motivation, instructions (oral hygiene instructions, OHI)\n* Professional mechanical plaque removal (PMPR), which includes the professional interventions aimed at removing supragingival plaque and calculus, as well as possible plaque-retentive factors that impair oral hygiene practices.\n* Adjustment of faulty restoration and polishing\n* The mechanical plaque control instructions for each patient include brushing and interdental cleaning techniques.",[14],[25],{"name":26,"role":27,"phone":28,"phoneExt":29,"email":30},"Husam Ghazi Alharbi, Master Degree","CONTACT","+201222284055","+20","husam.ghazi@dentistry.cu.edu.eg",[32,40],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":12,"geoPoint":12,"contacts":12},"Faculty of Dentistry-Cairo University","RECRUITING","Manial","Cairo Governorate","12311","Egypt","EG",{"facility":41,"status":34,"city":42,"state":12,"zip":12,"country":38,"countryCode":39,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"faculty of dentistry Cairo university","Cairo",{"type":44,"coordinates":45},"Point",[46,47],31.24967,30.06263,{"lat":47,"lon":46},[50],{"name":51,"role":27,"phone":52,"phoneExt":12,"email":30},"Husam Ghazi alharbi","0223642705",{"type":54,"investigatorFullName":55,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"PRINCIPAL_INVESTIGATOR","Husam Ghazi Dwerj Alharbi","100576758","assessment-of-pro-resolution-mediator-levels-in-periodontitis-stage-iii-and-iv-before-and-after-periodontal-therapy-100576758",false,"NCT06789458","Assessment of Pro-Resolution Mediator Levels in Periodontitis Stage III and IV Before and After Periodontal Therapy","Inclusion Criteria:\n\nInclusion criteria:\n\n1. Adult patients above 18 years old.\n2. Interdental CAL at site of greatest loss ≥5 mm or extending to middle third of the root.\n3. Interdental CAL at site of greatest loss ≥8 mm or extending to apical third of the root.\n4. Probing depth ≥6 mm.\n5. Vertical bone loss ≥3 mm.\n6. Tooth loss due to periodontitis of ≤4 teeth. (Periodontitis Stage III)\n7. Tooth loss due to periodontitis of ≥5 teeth. (Periodontitis Stage IV)\n8. Furcation involvement Class II or III Moderate ridge defect.\n\n   \\-\n\nExclusion Criteria:\n\n* 1\\. Pregnancy or lactation. 2. Smoking more than 20 cigarettes. 3. Immuno-inflammatory conditions of the skin and oral mucosa 4. systemic conditions affecting bone turnover and periodontal health status (e.g. endocrine and connective tissue diseases, bisphosphonate antiresorptive therapy, gastrointestinal diseases related to nutrition and mineral metabolism) 5. Periodontal or orthodontic treatment at least 6 months before the start of the study 6. Use of anti-inflammatory and antimicrobial agents within 3 months before sampling\n\nInclusion criteria for healthy group:\n\n1. Systemically healthy patients.\n2. Patients with an age range between 16 to 80 years.\n3. Patients have a minimum of 20 teeth.\n4. Less than 10% bleeding sites with probing depths ≤3 mm.\n5. absence of erythema, oedema.","ALL","18 Years","80 Years",{"count":66,"type":67},22,"ESTIMATED","INTERVENTIONAL",[70],"NA","This study aims to assess Pro-Resolution Mediator levels during non-surgical periodontal therapy in individuals with Stage III and IV periodontitis, comparing them to healthy subjects. Periodontitis, a chronic inflammatory condition affecting tooth-supporting tissues, can lead to tooth loss and systemic complications. Understanding the role of pro-resolving lipid mediators in inflammation resolution may offer insights into therapeutic benefits associated with these mediators.",[73],"Peridontal Disease",[75,76],"lipoxin","proresolution mediators","2025-01-17",{"date":79,"type":80},"2025-01-23","ACTUAL",{"date":82,"type":80},"2022-10-15",{"date":84,"type":67},"2025-10-14",{"name":5,"class":6},2]