[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584188":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":28,"responsibleParty":47,"collaborators":10,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":71,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Non-Obese",null,"Participants with a BMI under 30",{"label":13,"type":10,"description":14,"interventionNames":10},"Obese","Participants with a BMI greater than or equal to 30",[16],{"name":17,"affiliation":5,"role":18},"Aleksandra Kukla, MD","PRINCIPAL_INVESTIGATOR",[20,25],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Jackie Reiter","CONTACT","507-538-2224","reiter.jacqulyn@mayo.edu",{"name":26,"role":22,"phone":10,"phoneExt":10,"email":27},"Maulik Lathiya, MBBS","lathiya.maulik@mayo.edu",[29],{"facility":5,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":37,"coordinates":38},"Point",[39,40],-92.4699,44.02163,{"lat":40,"lon":39},[43,45],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":44},"REITER.JACQULYN@MAYO.EDU",{"name":46,"role":18,"phone":10,"phoneExt":10,"email":10},"Alexasandra Kukla, MD",{"type":18,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Aleksandra Kukla","Consultant Nephrology","100584188","assessment-of-risks-of-perinephric-fat-thickness-to-adverse-renal-outcomes-post-donor-nephrectomy-100584188",false,"NCT06886087","Assessment of Risks of Perinephric Fat Thickness to Adverse Renal Outcomes Post Donor Nephrectomy","Prospective Study to Assess the Risks of Perinephric Fat Thickness on Adverse Renal Outcomes Post Donor Nephrectomy - ProActive Study","ProActive","Inclusion Criteria:\n\n* Participants in this study will be restricted to living kidney transplant donors (LKDs). .\n\nExclusion Criteria:\n\n* Those who do not meet Mayo Clinic Rochester's clinical criterion for donor nephrectomy.\n* \\>10% weight change between the donor evaluation and donor nephrectomy\n* Individuals who are pregnant or are planning to become pregnant\n* Inability to comply with study procedures or any condition that, in the opinion of the investigator, could increase the patient's risk by participating in the study or confound the outcome of the study.",true,"ALL","18 Years","80 Years",{"count":63,"type":64},100,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn if PRAT thickness is a marker of visceral obesity and its influence on donors' kidney function and blood pressure in living kidney donors. Population includes male\u002Ffemale, 18 years and up, living kidney donors scheduled for nephrectomy within 6 months. The main area it aims to help in, is future care managing blood pressure and obesity in living kidney transplant donors.\n\nPrimary Hypothesis: We hypothesize that Perirenal Fat Thickness (PRAT) may exhibit expansion, remodeling and inflammation that can negatively affect renal outcomes in LKDs.\n\nResearchers will compare PRAT morphology and inflammation in LKDs with low and high PRAT thickness.\n\nWe will also correlate PRAT thickness with renal outcomes including vascular remodeling, at the time of donation and worsening hypertension and inadequately increased compensatory GFR of the LKD at 4-6 months post-donation.\n\nParticipants will be separated into one of two groups depending on their PRAT measurement and asked to give samples of their blood, perinephric fat, and urine as research samples. Clinically we will abstract data up to 12 months prior and 6 months after their nephrectomy that includes laboratory findings, CT measurements, vitals, exam data, demographics, medical history and current medications.",[68,69,70],"Living Kidney Donation","Hypertension","Nephrectomy",[72,73],"healthy volunteers","kidney donation","2026-02-13",{"date":76,"type":77},"2026-02-17","ACTUAL",{"date":79,"type":77},"2025-02-10",{"date":81,"type":64},"2028-02-10",{"name":5,"class":6},1]