[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100597123":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":32,"locations":39,"responsibleParty":61,"collaborators":37,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":37,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":37,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":37,"overallStatus":42,"whyStopped":37,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Aswan University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group I (Study Group)","ACTIVE_COMPARATOR","About 30 patients suffering from moderate and severe acne Vulgaris",[13],"Drug: Isotretinoin",{"label":15,"type":16,"description":17,"interventionNames":18},"Group II (Control Group)","PLACEBO_COMPARATOR","About 30 Healthy persons",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Isotretinoin","* Measure the serum levels of catestatin in patients with moderate and severe acne vulgaris versus healthy control persons.\n* Evaluate the effect of oral isotretinoin treatment on serum catestatin levels in patients with moderate and severe acne vulgaris.",[9,15],[26],"Catestatin",[28],{"name":29,"affiliation":30,"role":31},"Moustafa Adam Ali El Taieb, Professor","Dermatology, Venereology and Andrology. Faculty of Medicine,Aswan University","STUDY_CHAIR",[33],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"Mona Zakaria Mohamed, MSc","CONTACT","+201142550119",null,"mona1704213@aswu.edu.eg",[40],{"facility":41,"status":42,"city":43,"state":37,"zip":37,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Aswan Unuversity Hospital","RECRUITING","Aswān","Egypt","EG",{"type":47,"coordinates":48},"Point",[49,50],32.89942,24.09082,{"lat":50,"lon":49},[53,57],{"name":54,"role":35,"phone":55,"phoneExt":37,"email":56},"Mahmoud Ahmed Ali, M.D","+201002364902","dr.mahmoudali@aswu.edu.eg",{"name":58,"role":35,"phone":59,"phoneExt":37,"email":60},"Mohamed Amer Ahmed Abdellatif, M.D","+201060394083","mohammed.abdellatif@aswu.edu.eg",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":37,"oldOrganization":37},"PRINCIPAL_INVESTIGATOR","Mona Zakaria Mohamed","Resident of Dermatology, at Faculty of medicine","100597123","assessment-of-serum-catestatin-level-in-acne-vulgaris-patients-100597123",false,"NCT07054398","Assessment of Serum Catestatin Level in Acne Vulgaris Patients","Assessment of Serum Catestatin Level in Acne Vulgaris Patients Before and After Treatment With Oral Isotretinoin","Inclusion Criteria:\n\n* Healthy persons of both sexes with moderate and severe acne.\n\nExclusion Criteria:\n\n* Pregnant and lactating women.\n* Immunocompromised patients.\n* Severe anemia.\n* History of chronic liver disease.\n* Hyperlipidemia\n* Non-inflammatory acne conditions.\n* History of neurologic disorders.\n* History of neoplastic disorders.\n* History of cardiac disease.\n* History of systemic acne treatment for at least 4 weeks prior to inclusion and no topical treatments for at least 2 weeks.\n* Cases with known hypersensitivity reaction to isotretinoin.",true,"ALL","18 Years","40 Years",{"count":77,"type":78},60,"ESTIMATED","INTERVENTIONAL",[81],"NA","Acne vulgaris is a persistent inflammatory condition of the pilosebaceous unit, affecting 85% of people between the ages of 12 and 24, it is regarded as one of the most common diseases in teenagers and young adults.\n\nCatestatin, a peptide derived from chromogranin A (CgA), was first discovered in 1997 as an acute nicotinic-cholinergic antagonist. Later, it was determined that CST is a pleiotropic hormone.",[84],"Acne Vulgaris","2025-06-27",{"date":87,"type":88},"2025-07-08","ACTUAL",{"date":90,"type":88},"2025-01-10",{"date":92,"type":78},"2026-01-10",{"name":5,"class":6},1]