[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100320017":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":30,"responsibleParty":52,"collaborators":20,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":20,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":32,"whyStopped":20,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"University of Calgary","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Stroke volume and cardiac output","EXPERIMENTAL","Pacing runs will occur at the following rates:\n\n* 50 beats per minute (bpm)\n* 60 bpm\n* 70 bpm\n* 80 bpm\n* 90 bpm\n* 100 bpm\n* 110 bpm\n* 120 bpm\n* 130 bpm\n\nThe finger blood pressure cuff will be calibrated between pacing runs.\n\nFollowing the final pacing run while supine, the patient will be given 10 minutes to rest prior to the upright portion of the study. They will then be strapped into the table (so they will not fall) and then they will be tilted up to \\>70 degrees (almost standing up). They will stand for \\~10 minutes prior to commencing the next pacing trains.",[13],"Device: Pacing",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Pacing","Assess the non-invasively determined stroke volume and cardiac output response at different paced heart rates in patients with a cardiac pacemaker or implanted defibrillator with preserved ejection fractions (LVEF≥50%)",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Satish R Raj, MD MSCI","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","4032106152","satish.raj@ucalgary.ca",[31],{"facility":5,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Calgary","Alberta","T2N 4Z6","Canada","CA",{"type":39,"coordinates":40},"Point",[41,42],-114.08529,51.05011,{"lat":42,"lon":41},[45,49],{"name":46,"role":27,"phone":47,"phoneExt":20,"email":48},"Satish R Raj, MD, MSCI","403-210-6152","autonomic.research@ucalgary.ca",{"name":50,"role":27,"phone":51,"phoneExt":20,"email":48},"Robert S Sheldon, MD, PhD","403-220-8191",{"type":53,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100320017","assessment-of-stroke-volume-and-cardiac-output-in-response-to-varying-heart-rates-100320017",false,"NCT03446326","Assessment of Stroke Volume and Cardiac Output in Response to Varying Heart Rates","Assessment of Stroke Volume and Cardiac Output in Response to Varying Heart Rates and Body Position - a Pacemaker Based Study","Pacing_SV","Inclusion Criteria:\n\n* Age 18-70 years (inclusive)\n* Implanted permanent pacemaker or implanted defibrillator capable of atrial and ventricular pacing\n* LV ejection fraction \\>50%\n\nExclusion Criteria:\n\n* Unable or unwilling to provide informed consent\n* Clinical need for a cardiac resynchronization device","ALL","18 Years","70 Years",{"count":66,"type":67},25,"ESTIMATED","INTERVENTIONAL",[70],"NA","The investigators will seek to determine the effects of different heart rates on both stroke volume and cardiac output using non-invasive hemodynamic assessments. In order to safely manipulate the HR, the investigators will study patients with permanent pacemakers in whom heart rate manipulation can be done in a safe and non-invasive manner.",[73],"Vasovagal Syncope",[75,76,77,78],"pacemaker","stroke volume","cardiac output","heart rate","2026-04-30",{"date":81,"type":82},"2026-05-05","ACTUAL",{"date":84,"type":82},"2018-01-01",{"date":86,"type":67},"2028-01-01",{"name":5,"class":6},1]