[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618870":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":46,"collaborators":20,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":20,"enrollmentInfo":57,"targetDuration":20,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":71,"whyStopped":20,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"University Hospital, Antwerp","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"DISE extended with additional measurements","EXPERIMENTAL","Patients who undergo hypoglossal nerve stimulation therapy will be recruited at the one year follow-up appointment at the department of ENT. As part of the standard clinical pathway, these patients will have a PSG and DISE planned one year after HNS-therapy intiation. Participants of this study will be invited to to have their one year follow-up DISE extended with additional measurements to assess the effect of HNS therapy on upper airway collapsibility.",[13],"Procedure: Additional measurements during clinical standard follow-up drug-induced sleep endoscopy (DISE)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Additional measurements during clinical standard follow-up drug-induced sleep endoscopy (DISE)","During standard DISE, type I polysomnography (Alice LDx 6, Philips Respironics) expanded with measurements of Pcrit (Pcrit3000 device, Philips Respironics) and airflow (Pneumotachometer, Hans-Rudolph, USA) will be performed.",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Eldar Tukanov, MD","CONTACT","+32 3 436 82 47","eldar.tukanov@uantwerpen.be",[28],{"facility":29,"status":20,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Antwerp University Hospital","Edegem","Antwerpen","2650","Belgium","BE",{"type":36,"coordinates":37},"Point",[38,39],4.44504,51.15662,{"lat":39,"lon":38},[42],{"name":43,"role":24,"phone":44,"phoneExt":20,"email":45},"Ethical Committee","+32 3 821 38 97","ethisch.comite@uza.be",{"type":47,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100618870","assessment-of-the-effect-of-hypoglossal-nerve-stimulation-therapy-on-upper-airway-collapsibility-during-drug-induced-sleep-endoscopy-100618870",false,"NCT07337239","Assessment of the Effect of Hypoglossal Nerve Stimulation Therapy on Upper Airway Collapsibility During Drug-induced Sleep Endoscopy","HNS-CoDSE","Inclusion Criteria:\n\n* 18 years or older.\n* Treated with HNS-therapy for OSA (AHI ≥15\u002Fhour sleep)\n* Capable of giving informed consent\n* Baseline polysomnography performed at Antwerp University Hospital\n\nExclusion Criteria:\n\n* Patients did not receive HNS-therapy at the Antwerp University Hospital\n* Central apneas accounting for ≥25% of total apneas during baseline polysomnography\n* Known medical history of intellectual disability, memory disorders or current psychiatric disorders (psychotic illness, major depression, or acute anxiety attacks as mentioned by the participant).\n* Simultaneous use of other treatment modalities to treat OSA (outside of HNS-therapy)\n* Esophageal ulceration, tumors, diverticulitis, bleeding varices, sinusitis, epistaxis, recent nasopharyngeal surgery\n* Pregnancy or willing to become pregnant\n* Excessive alcohol or drug use (\\> 20 alcohol units\u002Fweek or any use of hard drugs)","ALL","18 Years",{"count":58,"type":59},21,"ESTIMATED","INTERVENTIONAL",[62],"NA","This clinical trial will evaluate the effect of treatment with hypoglossal nerve stimulation on the underlying mechanisms of obstructive sleep apnea. Several disease mechanism parameters are known to be associated with obstructive sleep apnea. However, currently, only the location of upper airway collapse is routinely examined in clinical practice using sleep endoscopy. Among other parameters, airway collapsibility is a widely studied mechanism. This parameter indicates how easily a patient's upper airway tends to collapse and can be assessed with additional measurements during sleep endoscopy.\n\nThe aim of this trial is to investigate the effect of hypoglossal nerve stimulation on collapsibility during sleep endoscopy. This information will provide a better understanding of the physiological mechanisms of hypoglossal nerve stimulation. In the long term, the investigators hope this knowledge will allow for more personalized care by tailoring treatment to the specific needs of each patient.",[65],"Obstructive Sleep Apnea",[67,68,69,70],"OSA","DISE","Endotyping","Collapsibility","NOT_YET_RECRUITING","2026-01-06",{"date":74,"type":75},"2026-01-13","ACTUAL",{"date":77,"type":59},"2026-01",{"date":79,"type":59},"2027-12-31",{"name":5,"class":6},1]