[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584784":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":28,"centralContacts":33,"locations":38,"responsibleParty":54,"collaborators":10,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":10,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":10,"studyType":69,"phases":10,"briefSummary":70,"conditions":71,"keywords":10,"overallStatus":41,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"National Cancer Institute, Naples","OTHER",[8,13,16,19],{"label":9,"type":10,"description":10,"interventionNames":11},"Cohort of women with endometrial carcinoma",null,[12],"Other: Metabolomic profiling",{"label":14,"type":10,"description":10,"interventionNames":15},"Cohort of healthy subjects to be used as controls",[12],{"label":17,"type":10,"description":10,"interventionNames":18},"Cohort of other non-oncological uterine conditions and oncological conditions affecting other organ",[12],{"label":20,"type":10,"description":21,"interventionNames":22},"Additional cohort will be recruited to validate the trained models","This cohort will consist of postmenopausal women, aged between 50 and 80 years.",[12],[24],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"Metabolomic profiling","Blood samples will be collected from these subjects, and following metabolomic profiling, the data will provide the foundation for training machine learning models capable of recognizing the metabolomic profiles of subjects with endometrial carcinoma and differentiating them from subjects with other conditions.",[20,14,17,9],[29],{"name":30,"affiliation":31,"role":32},"Antonella De Luca","IRCCS I.N.T. \"G. Pascale\"","PRINCIPAL_INVESTIGATOR",[34],{"name":30,"role":35,"phone":36,"phoneExt":10,"email":37},"CONTACT","08117770603","a.deluca@istitutotumori.na.it",[39],{"facility":40,"status":41,"city":42,"state":10,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Istituto Nazionale Tumori | \"Fondazione Pascale\"","RECRUITING","Naples","80131","Italy","IT",{"type":47,"coordinates":48},"Point",[49,50],14.26811,40.85216,{"lat":50,"lon":49},[53],{"name":30,"role":35,"phone":36,"phoneExt":10,"email":37},{"type":55,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100584784","assessment-of-the-effectiveness-of-the-metabolomic-approach-in-screening-for-endometrial-cancer-100584784",false,"NCT06893861","Assessment of the Effectiveness of the Metabolomic Approach in Screening for Endometrial Cancer","Inclusion Criteria:\n\n1. Female sex\n2. Age between 50 and 80 years\n3. Willingness to participate in the study and signing of the informed consent\n4. Clinical condition of post-menopause\n\nExclusion Criteria:\n\n1. Previous hysterectomy\n2. Hormone replacement therapy\n3. Immunosuppressive therapy",true,"FEMALE","50 Years","80 Years",{"count":67,"type":68},3100,"ESTIMATED","OBSERVATIONAL","The study involves the use of reagents or materials for diagnostic assessments that are not commercially available, specifically a metabolomic signature for screening endometrial carcinoma and\u002For other types of cancers, and follows a case-control design.\n\nThis study aims to achieve several objectives that contribute to evaluating the diagnostic potential of a specific \"metabolomic signature\" to be used for screening endometrial carcinoma. Specifically, the study seeks to assess the signature's discriminative ability in differentiating between benign endometrial neoplasms and neoplasms of different histological origins.",[72],"Endometrial Carcinoma (EC)","2025-03-18",{"date":75,"type":76},"2025-03-25","ACTUAL",{"date":78,"type":76},"2023-07-06",{"date":80,"type":68},"2025-07",{"name":5,"class":6},1]