[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627978":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":28,"locations":38,"responsibleParty":59,"collaborators":17,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":17,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":17,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":41,"whyStopped":17,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Al-Azhar University","OTHER",[8,13],{"label":9,"type":10,"description":9,"interventionNames":11},"patients will receive local application of vitamin D3 combined with corticision","EXPERIMENTAL",[12],"Drug: patients will receive local application of vitamin D3 combined with corticision",{"label":14,"type":15,"description":16,"interventionNames":17},"Control","NO_INTERVENTION","patients will receive conventional treatment",null,[19],{"type":20,"name":9,"description":21,"armGroupLabels":22,"otherNames":17},"DRUG","Administration of the Solution at eexperimental side:\n\nOne milliliter of was injected into the buccal vestibule at the level of the distal margin of the root of the canine.\n\nOne milliliter of (ONE ALPHA 2 MCG \u002F ML 10 AMP 0.5 ML Leo Pharmaceutical products Ballerup - Denmark. Imported by: Egyptian Company for Drug Trading) was injected four times during treatment on the the beginning (T0), 4 weeks (T1), 8 weeks (T2), and 12 weeks (T3) of canine retraction on both sides according to Varughese, et al.\n\n\" Participants were evaluated from the beginning (T0), 4 weeks (T1), 8 weeks (T2), and 12 weeks (T3) of canine distalization. At these appointments, impressions were made to obtain the study models. Multi-slice spiral computed tomography scans were taken at T0 and T3 to measure the changes in bone density following canine distalization. The primary outcome was to evaluate the rate and total amount of canine distalization as well as anchorage loss in the maxillary arch. All study measurements",[9],[24],{"name":25,"affiliation":26,"role":27},"Dr. Ramadan Yusuf Abu-Shahba Y Dr. Ramadan Yusuf Abu-Shahba, PhD","rmadanyusf@azhar.edu.eg","STUDY_DIRECTOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":17,"email":33},"Mahmoud Elsaid Elsayed E Mahmoud Elsaid, BDS","CONTACT","+201003221008","mahmoud_elsaid@azhar.edu.eg",{"name":35,"role":31,"phone":36,"phoneExt":17,"email":37},"Dr. Mahmoud Fathy Aboelmahasen F Dr. Mahmoud F. Aboelmahasen, PhD","+201222993381","MahmoudFathy.209@azhar.edu.eg",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Orthodontic Outpatient Clinic, Faculty of Dental Medicine, Al-Azhar University","RECRUITING","Cairo","Cairo Governorate","11651","Egypt","EG",{"type":48,"coordinates":49},"Point",[50,51],31.24967,30.06263,{"lat":51,"lon":50},[54,56],{"name":55,"role":31,"phone":32,"phoneExt":17,"email":33},"Mahmoud E Elsaid, BDS",{"name":57,"role":31,"phone":58,"phoneExt":17,"email":37},"Dr. Mahmoud Fathy Aboelmahasen F Dr. Mahmoud F Aboelmahasen, PhD","+20 12 22993381",{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":17,"oldOrganization":17},"PRINCIPAL_INVESTIGATOR","Mahmoud Elsaid","MSc Student in Orthodontics","100627978","assessment-of-the-locally-administrated-vitamin-d3-and-corticision-efficacy-on-orthodontic-canine-retraction-100627978",false,"NCT07455656","Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine Retraction","Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine Retraction: A Prospective Clinical Study","Inclusion criteria:\n\n1. Orthodontic patients referred for therapeutic extraction of bilateral maxillary first premolars (Angle Class II division 1 cases, with crowding and bimaxillary protrusion).\n2. Fully erupted permanent teeth (except third molar).\n3. Age 13-20 patients.\n4. No previous orthodontic treatment.\n5. Good oral and general health.\n6. No systemic disease or regular medication that could interfere with and\u002For affect orthodontic teeth movement.\n\nExclusion criteria:\n\n1. Patients with impacted canines.\n2. Patients with severe crowding.\n3. Patients with untreated decay or any endodontic lesions.\n4. Patients with thyroid, parathyroid, or renal and liver disease.",true,"ALL","13 Years","20 Years",{"count":75,"type":76},16,"ESTIMATED","INTERVENTIONAL",[79],"NA","To study the effect vitamin D effect on orthodontic tooth movement when used in combination with coticision technique, independent t test or an equivalent non-parametric test will be used for comparison. According to a previous study by (S. T. Varughese, et al. (2019) , \"Effect of vitamin D on canine distalization and alveolar bone density using multi-slice spiral CT: a randomized controlled trial",[82,83],"Malocclusions","Canine Retraction",[85,86,87],"Orhodontic tooth movement","Canine retraction","Extraction first premolars","2026-03-03",{"date":90,"type":91},"2026-03-06","ACTUAL",{"date":93,"type":91},"2025-08-01",{"date":95,"type":76},"2027-08-01",{"name":5,"class":6},1]