[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100392549":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":29,"responsibleParty":49,"collaborators":19,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":19,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":19,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":32,"whyStopped":19,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"University of Calgary","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients Scheduled for Elective Electrophysiological Study","EXPERIMENTAL","High right atrial pacing will occur at the following rates for 60 seconds each, with a rest period of at least 60 seconds between pacing runs:\n\n* 600 msec (100 bpm)\n* 500 msec (120 bpm)\n* 400 msec (150 bpm)\n* 350 msec (171 bpm)",[13],"Other: Electrophysiological Pacing",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Electrophysiological Pacing","Assess the MCA CBF velocity response at different paced heart rates.",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Satish R Raj, MD MSCI","PRINCIPAL_INVESTIGATOR",[25],{"name":22,"role":26,"phone":27,"phoneExt":19,"email":28},"CONTACT","403-210-6152","satish.raj@ucalgary.ca",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Foothills Medical Center","RECRUITING","Calgary","Alberta","T2N 4Z6","Canada","CA",{"type":39,"coordinates":40},"Point",[41,42],-114.08529,51.05011,{"lat":42,"lon":41},[45],{"name":46,"role":26,"phone":47,"phoneExt":19,"email":48},"Satish Raj, MD MSCI","4032106152","autonomic.research@ucalgary.ca",{"type":50,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100392549","assessment-of-the-relationship-between-cerebral-blood-flow-and-heart-rate-100392549",false,"NCT04391465","Assessment of the Relationship Between Cerebral Blood Flow and Heart Rate","Assessment of the Relationship Between Cerebral Blood Flow and Heart Rate: An Electrophysiology Based Study","Inclusion Criteria:\n\n* Male or female\n* Age 18-70 years, inclusive\n* Scheduled for clinically indicated elective electrophysiological studies where temporary pacing catheters are being placed in the right atrium\n* Left ventricular ejection fraction ≥50%\n* Able and willing to provide informed consent\n* Able to travel to the Cardiac Electrophysiology Laboratory at the Foothills Medical Centre, Calgary, Alberta, Canada\n\nExclusion Criteria:\n\n* Unable or unwilling to provide informed consent\n* Other factors which in the investigator's opinion would prevent the participant from completing the protocol","ALL","18 Years","70 Years",{"count":62,"type":63},20,"ESTIMATED","INTERVENTIONAL",[66],"NA","The investigators will seek to determine the relationship between heart rate and middle cerebral artery (MCA) cerebral blood flow (CBF), as well as better understand the hemodynamic determinants of MCA CBF velocity. In order to manipulate heart rate, the investigators will recruit patients already scheduled for clinically indicated elective electrophysiological studies, where temporary pacing catheters placed in the right atrium can be used to artificially pace the heart at controlled rates. MCA CBF will be measured by transcranial Doppler ultrasound.",[69,70],"Cerebrovascular Circulation","Physiology",[72],"Cerebral Blood Flow","2026-04-30",{"date":75,"type":76},"2026-05-07","ACTUAL",{"date":78,"type":76},"2021-08-11",{"date":80,"type":63},"2027-12",{"name":5,"class":6},1]