[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100233562":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":27,"locations":34,"responsibleParty":53,"collaborators":32,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":58,"sex":64,"minAge":65,"maxAge":32,"enrollmentInfo":66,"targetDuration":32,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":32,"overallStatus":36,"whyStopped":32,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Cedars-Sinai Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Pre-existing bioprosthetic aortic valve","EXPERIMENTAL","Patients with a history of surgical or transcatheter valve replacement with bioprosthetic valves undergo cardiac contrast CT imaging and transthoracic echocardiography to evaluate structural and functional integrity of the aortic valves. Patients with prosthetic valve abnormalities suggestive of thrombus will be administered anticoagulation therapy with Vitamin K antagonists (Warfarin) for 3 months with goal INR 2-3, followed by repeat contrast CT of the chest and transthoracic imaging. Repeat imaging following 3 months of anticoagulation therapy is performed to evaluate the response to anticoagulation therapy.",[13],"Drug: Warfarin",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","Warfarin","Patients with prosthetic valve abnormalities suggestive of thrombus will be administered anticoagulation therapy with Vitamin K antagonists (Warfarin) for 3 months with goal INR 2-3, followed by repeat contrast CT of the chest and transthoracic imaging. Repeat imaging following 3 months of anticoagulation therapy is performed to evaluate the response to anticoagulation therapy.",[9],[21],"Coumadin",[23],{"name":24,"affiliation":25,"role":26},"Raj Makkar, MD","Cedars-Sinai Medical Center, Los Angeles, California","PRINCIPAL_INVESTIGATOR",[28],{"name":29,"role":30,"phone":31,"phoneExt":32,"email":33},"Tarun Chakravarty, MD","CONTACT","3104233977",null,"tarunchakravarty@gmail.com",[35],{"facility":5,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Los Angeles","California","90048","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-118.24368,34.05223,{"lat":46,"lon":45},[49,51],{"name":29,"role":30,"phone":31,"phoneExt":32,"email":50},"Tarun.Chakravarty@cshs.org",{"name":52,"role":26,"phone":32,"phoneExt":32,"email":32},"Raj R Makkar, MD",{"type":26,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"Raj Makkar","Associate Director, Cedars-Sinai Heart Institute; Professor of Medicine, University of California, Los Angeles; Director, Cardiac Catheterization Laboratories and Intervention Center","100233562","assessment-of-transcatheter-and-surgical-aortic-bioprosthetic-valve-thrombosis-and-its-treatment-with-anticoagulation-100233562",false,"NCT02318342","Assessment of TRanscathetEr and Surgical Aortic BiOprosthetic Valve Thrombosis and Its TrEatment With Anticoagulation","Assessment of TRanscathetEr and Surgical Aortic BiOprosthetic Valve Dysfunction With Multimodality Imaging and Its TrEatment With Anticoagulation","RESOLVE","Inclusion Criteria:\n\n* Presence of transcatheter or surgical bioprosthetic aortic valve implanted at least 48 hours prior to enrollment\n* Age 18 years or older\n* Ability to provide informed consent and follow-up with protocol procedures.\n\nExclusion Criteria:\n\n* Renal insufficiency (creatinine \\> 1.5 mg\u002FdL)\n* Known allergy to iodinated contrast agents","ALL","18 Years",{"count":67,"type":68},3000,"ESTIMATED","INTERVENTIONAL",[71],"NA","This is a prospective study designed to evaluate the structural and functional integrity of transcatheter or surgical bioprosthetic valves with multimodality imaging. The study further aims to confirm resolution of the early bioprosthetic valve thrombotic changes with anticoagulation.",[74],"Prosthetic Valve Thrombosis","2026-06-15",{"date":77,"type":78},"2026-06-16","ACTUAL",{"date":80,"type":32},"2014-12",{"date":82,"type":68},"2028-12",{"name":5,"class":6},1]