[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640028":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":51,"centralContacts":56,"locations":62,"responsibleParty":80,"collaborators":10,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":10,"eligibilityCriteria":89,"healthyVolunteers":85,"sex":90,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":10,"studyType":96,"phases":10,"briefSummary":97,"conditions":98,"keywords":10,"overallStatus":103,"whyStopped":10,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patient",null,"Patients with lipedema",[13,14,15,16,17,18],"Diagnostic Test: Venous Doppler Ultrasonography","Other: Numeric Rating Scale","Other: Lower Extremity Functional Scale","Other: Short Form-12","Other: Circumference Measurements","Other: Clinical Staging",[20,25,31,37,43,47],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"DIAGNOSTIC_TEST","Venous Doppler Ultrasonography","Participants will undergo lower extremity venous Doppler ultrasonography to evaluate venous insufficiency findings, including venous reflux characteristics, affected venous segments, and venous diameters in the superficial and deep venous systems.",[9],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"Numeric Rating Scale","Pain intensity will be evaluated using the Numeric Rating Scale, ranging from 0 (no pain) to 10 (worst imaginable pain).",[9],[30],"NRS",{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"Lower Extremity Functional Scale","Functional status will be assessed using the Lower Extremity Functional Scale. The total score ranges from 0 to 80, with higher scores indicating better lower extremity function and lower disability levels.",[9],[36],"LEFS",{"type":6,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"Short Form-12","Health-related quality of life will be assessed using the SF-12 questionnaire, including the Physical Component Summary (PCS-12) and Mental Component Summary (MCS-12) scores. Scores range from 0 to 100, with higher scores indicating better perceived health status and quality of life.",[9],[42],"SF-12",{"type":6,"name":44,"description":45,"armGroupLabels":46,"otherNames":10},"Circumference Measurements","Lower extremity circumferences will be measured at predefined anatomical landmarks to evaluate limb involvement",[9],{"type":6,"name":48,"description":49,"armGroupLabels":50,"otherNames":10},"Clinical Staging","Lipedema stage will be determined according to clinical examination findings and established diagnostic criteria.",[9],[52],{"name":53,"affiliation":54,"role":55},"Feyza Yücel, Assoc. Prof.","Sultan 2.Abdülhamid Han Research and Training Hospital","PRINCIPAL_INVESTIGATOR",[57],{"name":53,"role":58,"phone":59,"phoneExt":60,"email":61},"CONTACT","(0216) 542 20 00","+90","dr.fny28@gmail.com",[63],{"facility":64,"status":10,"city":65,"state":66,"zip":10,"country":67,"countryCode":10,"cosmosGeoPoint":68,"geoPoint":73,"contacts":74},"Department of Physical Medicine and Rehabilitation, Health Sciences University Sultan Abdulhamid Han Training and Research Hospital","Istanbul","Uskudar","Turkey (Türkiye)",{"type":69,"coordinates":70},"Point",[71,72],28.94966,41.01384,{"lat":72,"lon":71},[75,77],{"name":76,"role":58,"phone":10,"phoneExt":10,"email":10},"Feyza Yücel, Assoc.Prof.",{"name":78,"role":79,"phone":10,"phoneExt":10,"email":10},"Şule Dayanç","SUB_INVESTIGATOR",{"type":55,"investigatorFullName":81,"investigatorTitle":82,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Feyza Nur Yucel","Assoc.Prof.","100640028","assessment-of-venous-insufficiency-and-clinical-features-in-lipedema-100640028",false,"NCT07603076","Assessment of Venous Insufficiency and Clinical Features in Lipedema","Evaluation of Venous Insufficiency and Its Association With Clinical Features in Patients With Lipedema: A Cross-Sectional Study","Inclusion Criteria:\n\n* Female participants aged 18 years or older\n* Clinically diagnosed lipedema according to established diagnostic criteria\n* Ability to provide written informed consent\n* Ability to complete clinical assessments and questionnaires\n\nExclusion Criteria:\n\n* History of lower extremity venous surgery or sclerotherapy\n* Known peripheral arterial disease\n* Secondary lymphedema or other causes of lower extremity edema\n* Active infection, cellulitis, or inflammatory disease affecting the lower extremities\n* Pregnancy or postpartum period\n* Neurological, rheumatological, or musculoskeletal disorders significantly affecting lower extremity function\n* Malignancy or severe systemic disease\n* Inability to undergo venous Doppler ultrasonography\n* Inability to understand or complete study assessments and questionnaires","FEMALE","18 Years","65 Years",{"count":94,"type":95},82,"ESTIMATED","OBSERVATIONAL","Lipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, pain, tenderness, edema, and functional impairment. Venous symptoms such as heaviness, swelling, and discomfort are frequently reported in individuals with lipedema; however, the relationship between venous Doppler ultrasonography findings and lipedema-related clinical manifestations remains insufficiently investigated. This cross-sectional controlled study aims to evaluate venous insufficiency parameters in patients with lipedema using Doppler ultrasonography and to examine their associations with pain severity, lower extremity function, disease severity, and quality of life.",[99,100,101,102],"Lipedema","Venous Insufficiency","Venous Disease","Disability Physical","NOT_YET_RECRUITING","2026-05-17",{"date":106,"type":107},"2026-05-22","ACTUAL",{"date":109,"type":95},"2026-05-20",{"date":111,"type":95},"2026-08-01",{"name":5,"class":6},1]