[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645023":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":31,"centralContacts":36,"locations":46,"responsibleParty":61,"collaborators":30,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":30,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":88,"whyStopped":30,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Centre Hospitalier Universitaire de Saint Etienne","OTHER",[8,14,18,21],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients CKD 3a","ACTIVE_COMPARATOR","Patients with stage 3a kidney disease during a nephrology consultation with an investigator (inclusion visit).",[13],"Other: Blood sampling and biomarker assessment",{"label":15,"type":10,"description":16,"interventionNames":17},"Patients CKD 3b","Patients with stage 3b kidney disease during a nephrology consultation with an investigator (inclusion visit).",[13],{"label":19,"type":10,"description":16,"interventionNames":20},"Patients CKD 4",[13],{"label":22,"type":10,"description":23,"interventionNames":24},"Patients CKD 5","Patients with stage 5 kidney disease during a nephrology consultation with an investigator (inclusion visit).",[13],[26],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Blood sampling and biomarker assessment","Single study visit during routine nephrology follow-up. Routine blood analyses are performed as standard care. Two additional tubes (maximum 10 mL) are collected:\n\n* EDTA plasma tube for measurements of intact FGF23 (iFGF23), C-terminal FGF23 (cFGF23), and hepcidin.\n* Serum tube for measurements of erythropoietin (EPO), 1,25-dihydroxyvitamin D, and TRAP5b.\n\nClinical and laboratory data collected include renal function parameters (eGFR, creatinine, urea, albuminuria), hematologic and iron metabolism markers (hemoglobin, ferritin, transferrin saturation, CRP), and bone-mineral metabolism markers (calcium, phosphate, PTH, vitamin D, bone alkaline phosphatase).",[9,15,19,22],null,[32],{"name":33,"affiliation":34,"role":35},"Christophe MARIAT, PHD","CHUSE","PRINCIPAL_INVESTIGATOR",[37,42],{"name":33,"role":38,"phone":39,"phoneExt":40,"email":41},"CONTACT","(0)477828739","+33","christophe.mariat@chu-st-etienne.fr",{"name":43,"role":38,"phone":44,"phoneExt":40,"email":45},"Clara PFENNINGER, CDP","(0)477120287","clara.pfenninger@chu-st-etienne.fr",[47],{"facility":48,"status":30,"city":49,"state":30,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"CHU de Saint-Etienne","Saint-Etienne","42055","France","FR",{"type":54,"coordinates":55},"Point",[56,57],4.39,45.43389,{"lat":57,"lon":56},[60],{"name":33,"role":38,"phone":39,"phoneExt":40,"email":41},{"type":62,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100645023","association-between-chronic-kidney-disease-stage-and-circulating-fgf23-cleavage-intensity-in-patients-with-chronic-kidney-disease-100645023",false,"NCT07676526","Association Between Chronic Kidney Disease Stage and Circulating FGF23 Cleavage Intensity in Patients With Chronic Kidney Disease","CLIFF","Inclusion Criteria:\n\n* MRC stage 3a-5 based on the most recent GFR measurement\n* Patient enrolled in or eligible for a social security program\n* Patients who have received informed consent regarding the study and have given their verbal consent to participate\n\nExclusion Criteria:\n\n* Active cancer or a history of cancer in remission for less than 5 years, or a history of cancer in remission for more than 5 years with specific oncological treatment still ongoing.\n* Participation in another study related to treatments for the disease\n* Patients under legal guardianship (legal guardianship or conservatorship)","MALE","55 Years","75 Years",{"count":74,"type":75},80,"ESTIMATED","INTERVENTIONAL",[78],"NA","This cross-sectional proof-of-concept study aims to investigate the relationship between chronic kidney disease (CKD) severity and circulating FGF23 cleavage intensity estimated by the iFGF23\u002FcFGF23 ratio. Eighty male patients aged 55-75 years with CKD stages 3a to 5 will be included (20 per stage). Blood samples obtained during routine nephrology care will be supplemented by two additional tubes to measure iFGF23, cFGF23, hepcidin, erythropoietin, 1,25-vitamin D and TRAP5b. The primary endpoint is the iFGF23\u002FcFGF23 ratio. Secondary analyses will evaluate the associations between FGF23 forms and renal, hematological, iron metabolism and mineral bone parameters. This study will provide the first human data on FGF23 cleavage alterations across CKD stages and may identify novel biomarkers for anemia and cardiovascular complications.",[81],"CKD - Chronic Kidney Disease",[83,84,85,86,87],"CKD","FGF23","iFGF23\u002FcFGF23 ratio","iron metabolism","anemia","NOT_YET_RECRUITING","2026-06-24",{"date":91,"type":92},"2026-06-30","ACTUAL",{"date":94,"type":75},"2026-09",{"date":96,"type":75},"2027-05",{"name":5,"class":6},1]