[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586658":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":23,"responsibleParty":113,"collaborators":116,"id":127,"slug":128,"hasResults":129,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":10,"eligibilityCriteria":133,"healthyVolunteers":134,"sex":135,"minAge":136,"maxAge":10,"enrollmentInfo":137,"targetDuration":140,"studyType":141,"phases":10,"briefSummary":142,"conditions":143,"keywords":150,"overallStatus":44,"whyStopped":10,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":168},{"fullName":5,"class":6},"Aristotle University Of Thessaloniki","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"ART group - Study group",null,"The study group will include pregnant individuals aged 18 years or older with singleton or multiple pregnancies conceived through assisted reproductive technologies. Participants will be recruited during routine first-trimester ultrasound examinations between 11 weeks plus 0 days and 13 weeks plus 6 days of gestation at participating fetal medicine units. Pregnancies with major fetal anomalies or known genetic conditions will be excluded from the primary analysis.",{"label":13,"type":10,"description":14,"interventionNames":10},"Natural conception group- Control group","The control group will include pregnant individuals aged 18 years or older with singleton or multiple pregnancies conceived spontaneously, without the use of assisted reproductive technologies. Participants will be recruited during routine first-trimester ultrasound examinations between 11 weeks plus 0 days and 13 weeks plus 6 days of gestation at participating fetal medicine units. Pregnancies with major fetal anomalies or known genetic conditions will be excluded from the primary analysis.",[16,21],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Themistoklis Dagklis","CONTACT","+302313312120","dagklis@auth.gr",{"name":22,"role":18,"phone":10,"phoneExt":10,"email":10},"Antonios Siargkas",[24,42,59,76,90,99],{"facility":25,"status":26,"city":27,"state":10,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"University Hospital of Pleven","NOT_YET_RECRUITING","Pleven","5800","Bulgaria","BG",{"type":32,"coordinates":33},"Point",[34,35],24.61666,43.41791,{"lat":35,"lon":34},[38],{"name":39,"role":18,"phone":40,"phoneExt":10,"email":41},"Petya Chaveeva","+359 64 884 100","chaveevapetya@gmail.com",{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":54,"contacts":55},"Aristotle University of Thessaloniki","RECRUITING","Thessaloniki","Central Macedonia","54124","Greece","GR",{"type":32,"coordinates":51},[52,53],22.93493,40.64072,{"lat":53,"lon":52},[56],{"name":22,"role":18,"phone":57,"phoneExt":10,"email":58},"+306940580900","antonis.siargkas@gmail.com",{"facility":60,"status":26,"city":61,"state":62,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"Complejo Hospitalario Universitario de Canarias","Santa Cruz de Tenerife","Canary Islands","38320","Spain","ES",{"type":32,"coordinates":67},[68,69],-16.25462,28.46824,{"lat":69,"lon":68},[72],{"name":73,"role":18,"phone":74,"phoneExt":10,"email":75},"Walter Plasencia","+34 922 67 80 00","walterplasencia@mac.com",{"facility":77,"status":26,"city":78,"state":10,"zip":79,"country":64,"countryCode":65,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"Universidad Francisco de Vitoria","Madrid","28223",{"type":32,"coordinates":81},[82,83],-3.70256,40.4165,{"lat":83,"lon":82},[86],{"name":87,"role":18,"phone":88,"phoneExt":10,"email":89},"Maria del Mar Gil","+34 913 24 80 64","mmar1984@gmail.com",{"facility":91,"status":26,"city":78,"state":10,"zip":92,"country":64,"countryCode":65,"cosmosGeoPoint":93,"geoPoint":95,"contacts":96},"Hospital Universitario de Torrejón","28850",{"type":32,"coordinates":94},[82,83],{"lat":83,"lon":82},[97],{"name":87,"role":18,"phone":98,"phoneExt":10,"email":89},"+34 916 26 26 26",{"facility":100,"status":26,"city":101,"state":10,"zip":102,"country":64,"countryCode":65,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"Hospital Clínico Universitario \"virgen de la Arrixaca\"","Murcia","30120",{"type":32,"coordinates":104},[105,106],-1.13004,37.98704,{"lat":106,"lon":105},[109],{"name":110,"role":18,"phone":111,"phoneExt":10,"email":112},"Katy De Paco","+34 968 36 95 00","katy.depaco@gmail.com",{"type":114,"investigatorFullName":17,"investigatorTitle":115,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Associate Professor of Obstetrics and Gynecology",[117,119,120,123,125],{"name":118,"class":6},"Hospital Universitario de Torrejón,Madrid",{"name":77,"class":6},{"name":121,"class":122},"University Hospital, Pleven, Bulgaria","UNKNOWN",{"name":124,"class":6},"Hospital Universitario Virgen de la Arrixaca",{"name":126,"class":6},"Hospital Universitario de Canarias","100586658","association-of-assisted-reproductive-technologies-parameters-with-the-perinatal-outcome-100586658",false,"NCT06918236","Association of Assisted Reproductive Technologies Parameters With the Perinatal Outcome","Association of Assisted Reproductive Technologies Parameters With the Perinatal Outcome in Singleton and Multiple Pregnancies: A Multicenter Prospective Cohort Study","Inclusion Criteria\n\n* Singleton or multiple pregnancies\n* Live fetus between 11 weeks plus 0 days and 13 weeks plus 6 days of gestation\n\nExclusion Criteria\n\n* Known genetic anomalies diagnosed before or after birth\n* Major fetal defects diagnosed before or after birth, such as acrania, holoprosencephaly, megacystis, exomphalos, congenital heart defects",true,"FEMALE","18 Years",{"count":138,"type":139},12084,"ESTIMATED","9 Months","OBSERVATIONAL","The goal of this prospective cohort study is to examine how different parameters of assisted reproductive technologies (ART) are associated with the perinatal outcome in individuals with singleton or multiple gestations. The main questions it aims to answer are:\n\nAre ART pregnancies associated with a higher risk of:\n\n* Small for gestational age neonates?\n* Fetal growth restriction, either early- or late-onset?\n* Development of preeclampsia?\n* Stillbirth (intrauterine fetal death after 22 weeks not due to known anomalies)?\n* Are certain ART parameters-such as the type of fertilization (e.g., IVF vs. ICSI), embryo stage at transfer, use of fresh vs. frozen embryos, or ovarian stimulation protocols-more strongly associated with adverse outcomes?\n\nAre ART pregnancies associated with placental and umbilical cord abnormalities, including:\n\n* Placenta previa?\n* Vasa previa?\n* Single umbilical artery?\n* Velamentous or marginal cord insertion?\n\nResearchers will compare outcomes between pregnancies conceived through ART and those conceived spontaneously.\n\nParticipants will:\n\n* Be individuals aged 18 or older undergoing routine first-trimester ultrasound between 11 and 14 weeks of gestation\n* Provide detailed medical, obstetric, and ART-related information\n* Undergo routine prenatal assessments, including ultrasound evaluations of fetal growth, Doppler studies, and placental characteristics\n* Have perinatal outcomes such as gestational age at birth, mode of delivery, birthweight, and complications systematically recorded\n\nStatistical models will be used to adjust for confounding factors such as maternal age, BMI, parity, and smoking.\n\nThe aim is to better understand how ART and specific ART parameters may influence maternal and neonatal health and to improve counseling and clinical care for people using fertility treatments.",[144,145,146,147,148,149],"Fetal Growth Restriction (FGR)","Preeclampsia","Stillbirth","Placenta Previa","Vasa Previa","Small for Gestational Age (SGA)",[151,145,152,153,154,155,156,149,157,158],"fetal growth restriction","stillbirth","placenta previa","vasa previa","Assisted reproductive techniques","ART","IVF","ICSI","2025-04-05",{"date":161,"type":162},"2025-04-09","ACTUAL",{"date":164,"type":162},"2024-10-01",{"date":166,"type":139},"2028-12",{"name":5,"class":6},6]