[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612089":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":19,"responsibleParty":31,"collaborators":19,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":19,"eligibilityCriteria":40,"healthyVolunteers":36,"sex":41,"minAge":42,"maxAge":19,"enrollmentInfo":43,"targetDuration":19,"studyType":46,"phases":47,"briefSummary":49,"conditions":50,"keywords":52,"overallStatus":56,"whyStopped":19,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":19},{"fullName":5,"class":6},"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Optic nerve sheath diameter (ONSD) ultrasound","EXPERIMENTAL","Optic nerve sheath diameter (ONSD) ultrasound to be performed at the following time points:\n\n1. Prior to the start of surgery\n2. At the start of cardiopulmonary bypass (CPB)\n3. At the end of cardiopulmonary bypass\n4. Admission to the ICU\n5. 1 hour after ICU admission\n6. 6 hours after ICU admission\n7. 24 hours after ICU admission\n8. Daily until hospital discharge for delirious patients or daily until discharge from the ICU for non-delirious patients.\n\nDelirium will be assessed by administering the Intensive Care Delirium Screening Checklist (ICDSC) to patients twice daily until discharge from ICU.",[13],"Procedure: Optic nerve sheath diameter (ONSD) ultrasound",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"PROCEDURE","Optic nerve sheath diameter (ONSD) ultrasound to be performed to measure diameter of the optic nerve sheath. Administration of the Intensive Care Delirium Screening Checklist (ICDSC) twice daily until discharge from the ICU.",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Mauricio Giraldo, MD","London Health Sciences Centre","PRINCIPAL_INVESTIGATOR",[26],{"name":22,"role":27,"phone":28,"phoneExt":29,"email":30},"CONTACT","5196858500","19873","mauricio.giraldo@lhsc.on.ca",{"type":24,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Mauricio Giraldo","Anesthesiologist, Assistant Professor","100612089","association-of-optic-nerve-sheath-diameter-and-postoperative-delirium-100612089",false,"NCT07249047","Association of Optic Nerve Sheath Diameter and Postoperative Delirium","Correlation Between Optic Nerve Sheath Diameter Measured by Ultrasound and Delirium in Cardiac Surgery","Inclusion Criteria:\n\n* A d u l t s ≥ 1 8 y e a r s .\n* Scheduled for cardiac surgery requiring cardiopulmonary bypass (CPB) (e.g., Coronary artery bypass graft (CABG), valve, combined procedures, aortic surgery).\n* Anticipated postoperative admission to the Cardiac ICU with expected stay \\>48 hours.\n* Preoperative ability to undergo ocular ultrasound examination (closed-eyelid scanning).\n* Provided informed consent to participate in this study.\n\nExclusion Criteria:\n\n* Known or suspected open-globe injury, penetrating ocular trauma, or intraocular foreign body.\n* Recent ocular surgery or intravitreal intervention within the past 6 weeks (if surgeon advises against periocular pressure).\n* Ocular conditions that invalidate ONSD measurement (e.g., severe proptosis, advanced optic neuropathies, orbital tumors) or obstruct ultrasound window (extensive periocular dressings, severe periorbital edema).\n* Known intracranial pathology expected to significantly alter baseline ONSD (e.g., large mass lesion with midline shift, obstructive hydrocephalus) or presence of external ventricular drain at baseline.\n* Severe facial trauma or unstable cervical spine precluding safe positioning for ocular ultrasound.\n* P r e g n a n c y .\n* Inability to perform serial ONSD assessments at scheduled timepoints (e.g., continuous prone positioning) despite reasonable accommodations.\n* Enrollment in a conflicting interventional trial that mandates deviations from delirium assessment or ONSD protocol.\n* Inability to communicate in the English language.","ALL","18 Years",{"count":44,"type":45},300,"ESTIMATED","INTERVENTIONAL",[48],"NA","Postoperative delirium is a sudden and reversible disturbance of mental function, occurring after surgery, characterized by confusion, inattention, and fluctuating mental status, which can manifest as agitation or lethargy. It is a common post-operative complication, especially in older adults, and is associated with longer hospital stays and worse recovery outcomes. Validated delirium screening tools such as the Intensive Care Delirium Screening Checklist (ICDSC) and the Richmond Agitation and Sedation Scale (RASS) are widely used tools to assess delirium. However, the sensitivity of these screening tools can be variable when used in real-world practice and may miss early cases of delirium. The optic nerve sheath is a protective sheath that encloses part of the optic nerve that is located at the back of the eye. Measurement of the optic nerve sheath diameter is usually done using ultrasound to detect increased cranial pressure. Previous studies that have been conducted have shown that increased ONSD may be associated with occurrence of postoperative delirium. The purpose of this study is to determine if there is an association between optic nerve sheath diameter (ONSD) and the occurrence of delirium after surgery. This study will be conducted at the London Health Sciences Centre and will include 300 patients.",[51],"Postoperative Delirium",[53,54,55],"Post operative delirium","Optic nerve sheath diameter","Anesthesia","NOT_YET_RECRUITING","2025-12-16",{"date":59,"type":60},"2025-12-23","ACTUAL",{"date":62,"type":45},"2026-02-01",{"date":64,"type":45},"2027-12-31",{"name":5,"class":6}]