[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100587426":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":24,"centralContacts":28,"locations":33,"responsibleParty":52,"collaborators":23,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":23,"enrollmentInfo":66,"targetDuration":23,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":35,"whyStopped":23,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"Patients with iTTP","Intervention: blood sampling during standard collection for routine testing, with additional sample for experimental analyses.",[12],"Procedure: blood sampling",{"label":14,"type":6,"description":15,"interventionNames":16},"Healthy donors","Intervention: blood sampling during standard donation, with an additional sample collected for experimental analyses.",[12],[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"PROCEDURE","blood sampling","Blood sampling for experimental analyses.",[14,9],null,[25],{"name":26,"affiliation":5,"role":27},"Ilaria Mancini, PhD","PRINCIPAL_INVESTIGATOR",[29],{"name":26,"role":30,"phone":31,"phoneExt":23,"email":32},"CONTACT","+390255035414","ilaria.mancini@guest.unimi.it",[34],{"facility":5,"status":35,"city":36,"state":23,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"RECRUITING","Milan","20122","Italy","IT",{"type":41,"coordinates":42},"Point",[43,44],9.18951,45.46427,{"lat":44,"lon":43},[47,48,49],{"name":26,"role":30,"phone":31,"phoneExt":23,"email":32},{"name":26,"role":27,"phone":23,"phoneExt":23,"email":23},{"name":50,"role":51,"phone":23,"phoneExt":23,"email":23},"Andrea Artoni, MD, PhD","SUB_INVESTIGATOR",{"type":27,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Ilaria Mancini","PhD","100587426","association-of-tnfaip3-with-immune-mediated-ttp-100587426",false,"NCT06928233","Association of TNFAIP3 With Immune-mediated TTP","Association of the TNFAIP3 Genomic Locus With Immune-mediated TTP","A20iTTP","Patients:\n\nInclusion Criteria:\n\n* Diagnosis of iTTP\n* Above 12 years of age\n* Caucasian, Italian origin\n* Written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Patients who do not meet the above-listed criteria will be excluded from participation in the study.\n\nControls will be healthy Italian volunteers of Caucasian ethnicity, with no history of thrombotic thrombocytopenic purpura, frequency-matched to cases by age and sex, and who have provided written informed consent to participate in the study.",true,"ALL","12 Years",{"count":67,"type":68},400,"ESTIMATED","INTERVENTIONAL",[71],"NA","This study aims to investigate whether genetic variation in the TNFAIP3 locus is associated with immune-mediated thrombotic thrombocytopenic purpura (iTTP), and whether such association is mediated by decreased expression of A20 (TNFAIP3). The study includes a case-control design to assess genotype-expression association and a cohort study to evaluate clinical outcomes such as disease relapse.",[74],"Thrombotic Thrombocytopenic Purpura, Acquired",[76,77,78],"A20","iTTP","TNFAIP3","2026-03-26",{"date":81,"type":82},"2026-03-27","ACTUAL",{"date":84,"type":82},"2025-04-07",{"date":86,"type":68},"2026-04",{"name":5,"class":6},1]