[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100572472":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":62,"collaborators":65,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":26,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":80,"minAge":81,"maxAge":26,"enrollmentInfo":82,"targetDuration":26,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":101,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"Universidade Federal do Rio de Janeiro","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"tACS+DCT","EXPERIMENTAL","5 daily sessions of 30 minutes of DCT using the BrainHQ platform while simultaneously receiving theta tACS (6Hz, 1.6mA) targeting the Left Dorsolateral Prefrontal Cortex.",[13,14],"Device: Transcranial Alternating Current Stimulation","Device: Digital Cognitive Training",{"label":16,"type":17,"description":18,"interventionNames":19},"SHAM+DCT","SHAM_COMPARATOR","5 daily sessions of 30 minutes of DCT using the BrainHQ platform while simultaneously receiving stimulation with the device in SHAM mode (with Ramp Up, no current during the session period and Ramp down) targeting the Left Dorsolateral Prefrontal Cortex.",[13,14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Transcranial Alternating Current Stimulation","An alternate eletric current of 1.6mA in theta frequency is applied in the scalp, using two eletrodes (5x5cm). The eletrodes are located aiming for the left dorsolateral prefrontal Cortex area.",[16,9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Digital Cognitive Training","Using a tablet, the participant will do exercises that were designed to stimulate cognitive domains, especially attention and memory. In this case, we use the BrainHQ platform.",[16,9],[32],{"name":33,"affiliation":34,"role":35},"Rogerio Panizzutti, Professor","UFRJ","PRINCIPAL_INVESTIGATOR",[37,41],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","+55:21-3938-5588","rogerio.panizzutti@ipub.ufrj.br",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Brunno Costa, PhD student","+55 31996773008","fc_brunno@hotmail.com",[46],{"facility":47,"status":48,"city":49,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Clínica da Memória - IPUB \u002F UFRJ","RECRUITING","Rio de Janeiro","22290140","Brazil","BR",{"type":54,"coordinates":55},"Point",[56,57],-43.18223,-22.90642,{"lat":57,"lon":56},[60],{"name":42,"role":38,"phone":61,"phoneExt":26,"email":44},"+5521997790223",{"type":35,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Rogerio Panizzutti, MD, PhD","Professor",[66,68,71],{"name":67,"class":6},"Alzheimer's Association",{"name":69,"class":70},"Rio de Janeiro State Research Supporting Foundation (FAPERJ)","OTHER_GOV",{"name":72,"class":70},"Conselho Nacional de Desenvolvimento Científico e Tecnológico","100572472","association-of-transcranial-alternating-current-stimulation-with-digital-cognitive-training-for-cognitive-remediation-in-older-adults-100572472",false,"NCT06733714","Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults","Inclusion Criteria:\n\n* Healthy subjects over 50 years old, with cognitive complaints\n\nExclusion Criteria:\n\n* Estimated Intelligence Quotient \\\u003C80\n* Dependence on psychoactive substances (DSM-V)\n* Severe psychiatric or neurological disorders\n* Uncorrected visual\u002Fhearing problems\n* History of syncope for an unexplained reason or seizure less than a year ago\n* Previous stroke\n* Use of anticoagulants\n* Intracranial metallic prosthesis or cardiac pacemaker\n* Any contraindication to performing tACS",true,"ALL","50 Years",{"count":83,"type":84},40,"ESTIMATED","INTERVENTIONAL",[87],"NA","BACKGROUND Cognitive decline in older adults, especially those who develop Mild Cognitive Impairment and Alzheimer's Disease, currently has limited options of pharmacological treatments, with modest efficacy.\n\nDigital Cognitive Training (DCT) and Transcranial Alternating Current Stimulation (tACS) are two promising tools for cognitive remediation in this population. In this exploratory study, we investigate feasibility, tolerability and preliminary effects of the association of both interventions in older adults with cognitive complaints.\n\nMETHODS Older adults with cognitive complaints are being enrolled for this study, which comprises 5 daily sessions of 30 minutes of DCT using the BrainHQ platform while simultaneously receiving theta tACS (6Hz, 1.6mA) targeting the Left Dorsolateral Prefrontal Cortex.",[90,91,92,93,94,95,96,97,98,99,100],"Cognitive Dysfunction","Alzheimer Disease","Mild Cognitive Impairment","Cognitive Decline","Frontotemporal Degeneration","Dementia","Dementia, Vascular","Lewy Body Disease","Beta-Amyloid","GFAP","Tau Protein",[102,103,104,105,106,107,108,109,110,111],"tacs","nibs","transcranial alternate current stimulation","mild cognitive impairment","MCI","ALzheimer","Cognition","Elderly","Older Adults","Cognitive enhancement","2024-12-09",{"date":114,"type":115},"2024-12-13","ACTUAL",{"date":117,"type":115},"2024-12-02",{"date":119,"type":84},"2027-03-01",{"name":5,"class":6},1]