[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100516803":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":22,"locations":32,"responsibleParty":51,"collaborators":10,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":10,"eligibilityCriteria":59,"healthyVolunteers":56,"sex":60,"minAge":61,"maxAge":10,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":10,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"University of Virginia","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Heart Failure",null,"Patients diagnosed with Heart Failure (HFrEF and HFpEF). Oral microbiome will be analyzed through tongue swabs, saliva samples, and a saliva rinse. Patients will undergo a maximal exercise test, blood draws, and vascular testing. Patients will have the option to participate in a supplementation assessment with concentrated beetroot juice.",{"label":13,"type":10,"description":14,"interventionNames":10},"Peripheral Artery Disease","Patients diagnosed with Peripheral Artery Disease (PAD). Oral microbiome will be analyzed through tongue swabs, saliva samples, and a saliva rinse. Patients will undergo a maximal exercise test, blood draws, and vascular testing. Patients will have the option to participate in a supplementation assessment with concentrated beetroot juice.",{"label":16,"type":10,"description":17,"interventionNames":10},"Healthy Controls","Individuals that are not diagnosed with cardiovascular disease. Oral microbiome will be analyzed through tongue swabs, saliva samples, and a saliva rinse. Patients will undergo a maximal exercise test, blood draws, and vascular testing. Patients will have the option to participate in a supplementation assessment with concentrated beetroot juice.",[19],{"name":20,"affiliation":5,"role":21},"Jason D Allen, PhD","PRINCIPAL_INVESTIGATOR",[23,28],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Casey C Derella, PhD","CONTACT","6092476377","bxg7vn@virginia.edu",{"name":29,"role":25,"phone":30,"phoneExt":10,"email":31},"Macy E Stahl, B.S.E.d","5719698323","mes4hm@virginia.edu",[33],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"UVA Student Health and Wellness Building","RECRUITING","Charlottesville","Virginia","22903","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-78.47668,38.02931,{"lat":45,"lon":44},[48],{"name":20,"role":25,"phone":49,"phoneExt":10,"email":50},"434-243-3508","ja6af@virginia.edu",{"type":21,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Jason Allen","Professor of Kinesiology","100516803","associations-between-the-microbiome-skeletal-muscle-perfusion-and-fitness-status-100516803",false,"NCT06009276","Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status","Inclusion Criteria:\n\n* Subjects must be able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent.\n* Subjects may be of either sex with age 18 years.\n\nExclusion Criteria:\n\n* Oral antibiotic use within previous four weeks\n* Oral disease or poor oral health as determined by the Oral Health Questionnaire\n* Using an antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use\n* Tobacco smokers\n* Pregnant or lactating females\n* Hypersensitivity to any ultrasound contrast agent\n* Inability to perform exercise\n* Unable to communicate effectively in English to the study team.\n* Diagnosis of chronic renal failure (GFR \\\u003C 60 ml\u002Fmin\u002F1.73m)\n* Subjects taking nitroglycerine (or inorganic nitrates), PDE-5 inhibitors (ex: Cialis, Viagra), and xanthine oxidase inhibitors (ex: Allopurinol).","ALL","18 Years",{"count":63,"type":64},70,"ESTIMATED","OBSERVATIONAL","The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle. This study is trying to find out if fitness status impacts the bacteria that are present in the oral microbiome (environment in the mouth) or the ability of the body to send blood to the skeletal muscle.\n\nParticipants will complete all or some of the following:\n\n* A mouth swab to assess the bacteria in their mouths.\n* Produce a saliva sample into a tube.\n* Cycle on a bike until you reach maximum effort.\n* Undergo blood draws\n* Wear a 24-hour non-invasive device that monitors blood pressure.\n* Drink 70mL (1\u002F3 of a cup) of concentrated beetroot juice once",[68,69,70,71],"Heart Failure, Systolic","Heart Failure, Diastolic","Peripheral Arterial Disease","Overweight and Obesity","2025-12-17",{"date":74,"type":75},"2025-12-24","ACTUAL",{"date":77,"type":75},"2023-08-30",{"date":79,"type":64},"2026-12",{"name":5,"class":6},1]