[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100579610":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":33,"responsibleParty":51,"collaborators":11,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":11,"eligibilityCriteria":59,"healthyVolunteers":56,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":11,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":35,"whyStopped":11,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Children's Hospital Los Angeles","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment Arm","EXPERIMENTAL",null,[13],"Behavioral: Cardio-oncology rehabilitation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"BEHAVIORAL","Cardio-oncology rehabilitation","Least 60 minutes of physical activity each day including vigorous-intensity and strengthening activities at least 3 days per week",[9],[21],{"name":22,"affiliation":5,"role":23},"Jennifer Su, MD","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":11,"email":29},"Obdulio Carreras","CONTACT","(323) 361-4663","ocarreras@chla.usc.edu",{"name":22,"role":27,"phone":31,"phoneExt":11,"email":32},"(323) 361-5136","jsu@chla.usc.edu",[34],{"facility":5,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"RECRUITING","Los Angeles","California","90027","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-118.24368,34.05223,{"lat":45,"lon":44},[48,49,50],{"name":26,"role":27,"phone":28,"phoneExt":11,"email":29},{"name":22,"role":27,"phone":31,"phoneExt":11,"email":32},{"name":22,"role":23,"phone":11,"phoneExt":11,"email":11},{"type":23,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Jennifer Su","Assistant Professor, Keck School of Medicine, University of Southern California","100579610","at-home-cardiac-rehabilitation-for-adolescents-at-risk-for-heart-failure-100579610",false,"NCT06826534","At-Home Cardiac Rehabilitation for Adolescents at Risk for Heart Failure","INCLUSION CRITERIA\n\n* Patients aged of 10-21 years at enrollment\n* Parent\u002Flegal guardian available for consent (if applicable), and patient available for assent and consent\n* History of anthracycline exposure +\u002F- radiation\n* Currently in remission, with at least 6 months off chemotherapy\n* Able to perform CPET\n* Baseline CPET with VO2 \\\u003C80% (at start of study, or CPET at CHLA after January 2020)\n* Smartphone compatible with Fitbit (own or parent\u002Flegal guardian's)\n* Ability to complete and send diary and Fitbit information on a weekly basis\n* Ability to participate in monthly virtual check-in visits\n* Baseline activity prior to intervention \\\u003C30min\u002Fday, 2x\u002Fweek\n\nEXCLUSION CRITERIA\n\n* Inability to obtain consent\u002Fassent\n* Unable to accurately perform quality of life survey independently\n* No other primary medical diagnosis (e.g., Down Syndrome, Wolff-Parkinson-White Syndrome, congenital heart disease) or history of cardiothoracic surgery\n* Contraindication to moderate activity (\\>3 METs). Examples include history of malignant arrhythmias, exercise-induced syncope, severe symptoms of HF (NYHA IV, ACC\u002FAHA Stage D)\n* Unable to perform CPET, echocardiogram, EKG, or obtain laboratory studies\n* Unable to perform mild activity for at least 0.5h\u002Fday and at least 2x\u002Fweek\n* Unable to come to hospital for study visits at 0 and 6 months\n* Unable to complete study-related surveys\n* Unable to complete and send diary and Fitbit information on a weekly basis\n* Unable to check-in monthly on virtual platform\n* On beta blockade\n* Pregnancy","ALL","0 Years","21 Years",{"count":64,"type":65},20,"ESTIMATED","INTERVENTIONAL",[68],"NA","The goal of this clinical trial is to explore the impact that an at-home cardio-oncology rehabilitation (CORE) may have on short-term cardiovascular fitness and psychosocial wellness in pediatric cancer survivors. The main question it aims to answer are\n\n* To evaluate the efficacy of an at-home CORE model on short-term cardiovascular fitness and psychosocial wellbeing in adolescent cancer survivors.\n* To evaluate the exercise adherence rate among adolescents at risk for heart failure and assess barriers to compliance.\n* To explore which specific CORE resources are of most value to patients in creating sustainable healthy lifestyle modifications.\n* Hypothesis: Pediatric cancer survivors who implement exercise and dietary recommendations will demonstrate improvement in cardiovascular fitness and general wellness. A multidisciplinary team approach can facilitate adherence to a moderately rigorous exercise prescription, and thus enhance the health benefits of a CORE program at CHLA.\n\nParticipants will undergo cardiovascular studies and a quality-of-life survey prior to exercise intervention, and at the end of the 6-month study period.",[71,72],"Cardiovascular Complication","Chemotherapeutic Toxicity",[74,75,76,77,78],"anthracycline exposure","cancer survivors","physical activity","pediatric oncology","cardiac rehabilitation","2025-02-12",{"date":81,"type":82},"2025-02-14","ACTUAL",{"date":84,"type":82},"2023-10-20",{"date":86,"type":65},"2025-12-31",{"name":5,"class":6},1]