[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638924":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":23,"responsibleParty":89,"collaborators":10,"id":91,"slug":92,"hasResults":93,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":99,"sex":100,"minAge":101,"maxAge":102,"enrollmentInfo":103,"targetDuration":10,"studyType":106,"phases":10,"briefSummary":107,"conditions":108,"keywords":111,"overallStatus":26,"whyStopped":10,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"Margan Biotech","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Creatine-based nutritional supplement",null,"Single prospective cohort of estrogen-depleted adult women (menopause or late perimenopause) receiving a creatine-based nutritional supplement for 12 weeks under routine clinical practice conditions.\n\nParticipants take a daily dose of the supplement (10 g), which contains creatine monohydrate, hydrolyzed collagen, hyaluronic acid, beta-alanine, magnesium, and vitamins A, C, E, and B6.\n\nIn addition, participants receive general recommendations for physical activity (including strength and aerobic exercise) consistent with standard clinical advice, without supervised training or structured intervention.\n\nThe study does not include randomization, control group, or experimental assignment, as it aims to evaluate adherence, acceptability, and tolerability of nutritional supplementation in a real-world setting.",[13],{"name":14,"affiliation":15,"role":16},"Silvia P Gonzalez, Doctor","Menoclinica by Palacios","STUDY_DIRECTOR",[18],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},"Silvia Martinez","CONTACT","+34606441146","silvia.martinez@marganbiotech.com",[24,47,59,73],{"facility":25,"status":26,"city":27,"state":27,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Clínica Palacios","RECRUITING","Madrid","28034","Spain","ES",{"type":32,"coordinates":33},"Point",[34,35],-3.70256,40.4165,{"lat":35,"lon":34},[38,42,44],{"name":39,"role":20,"phone":40,"phoneExt":10,"email":41},"Santiago Palacios, Doctor","+34915780517","santiago.palacios@clinicapalacios.com",{"name":39,"role":43,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"name":45,"role":46,"phone":10,"phoneExt":10,"email":10},"Raquel Miguel, Doctor","SUB_INVESTIGATOR",{"facility":15,"status":26,"city":27,"state":27,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":48,"geoPoint":50,"contacts":51},{"type":32,"coordinates":49},[34,35],{"lat":35,"lon":34},[52,56,57],{"name":53,"role":20,"phone":54,"phoneExt":10,"email":55},"Silvia P González, Doctor","+34 914 32 44 99","silviapgonzalez@yahoo.es",{"name":14,"role":43,"phone":10,"phoneExt":10,"email":10},{"name":58,"role":46,"phone":10,"phoneExt":10,"email":10},"Esmeralda Josa, Nutritionist",{"facility":60,"status":26,"city":27,"state":27,"zip":61,"country":29,"countryCode":30,"cosmosGeoPoint":62,"geoPoint":64,"contacts":65},"Ginegetafe","28901",{"type":32,"coordinates":63},[34,35],{"lat":35,"lon":34},[66,70,71],{"name":67,"role":20,"phone":68,"phoneExt":10,"email":69},"Carmen Pingarron, Doctor","+34 915 78 05 17","cpingarrons@gmail.com",{"name":67,"role":43,"phone":10,"phoneExt":10,"email":10},{"name":72,"role":43,"phone":10,"phoneExt":10,"email":10},"Silvia Poyo, Doctor",{"facility":74,"status":75,"city":76,"state":76,"zip":77,"country":29,"countryCode":30,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"Clinica Palacios Málaga","NOT_YET_RECRUITING","Málaga","29016",{"type":32,"coordinates":79},[80,81],-4.42034,36.72016,{"lat":81,"lon":80},[84,88],{"name":85,"role":20,"phone":86,"phoneExt":10,"email":87},"Rodrigo Orozco, Doctor","+34 951 55 63 76","rodrigo.orozco@quironsalud.es",{"name":85,"role":43,"phone":10,"phoneExt":10,"email":10},{"type":90,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100638924","atenea-study-adherence-to-creatine-based-nutritional-supplementation-in-estrogen-depleted-women-100638924",false,"NCT07580846","ATENEA Study: Adherence to Creatine-Based Nutritional Supplementation in Estrogen-Depleted Women","AssessmenT of thE Adherence of Nutritional Supplementation With Creatine Formula in Estrogen-Depleted Adult Women: Prospective Clinical Investigation","ATENEA","Inclusion Criteria:\n\n* Biological female sex.\n* Age ≥40 years.\n* Estrogen-depleted status, defined as at least one of the following:\n\nnatural menopause, defined as amenorrhea for ≥12 consecutive months; surgically induced menopause; late perimenopause with elevated FSH according to clinical judgment.\n\n* Absence of major comorbidities that would contraindicate use of the nutritional supplement or the recommended physical activity.\n* No relevant changes in usual treatment during the previous 3 months.\n* Ability to understand the study information and provide written informed consent.\n* Willingness to take the nutritional supplement according to the study instructions.\n* Willingness to follow general physical activity recommendations provided by the investigator.\n* Willingness and ability to attend the planned visits and complete study assessments through Week 12.\n\nExclusion Criteria:\n\n* Initiation or modification of treatment with GLP-1 receptor agonists within the previous 12 weeks.\n* Presence of musculoskeletal or joint conditions that significantly limit the ability to perform regular physical activity or study-related functional assessments.\n* Clinically relevant renal or hepatic disease.\n* Current use of diuretics or potentially nephrotoxic medications.\n* Known allergy or intolerance to any component of the nutritional supplement.\n* Participation in another clinical study (nutritional, pharmacological, or interventional) within the previous 3 months.\n* Any medical condition or social circumstance that, in the investigator's judgment, could interfere with study participation, adherence, or data validity.",true,"FEMALE","40 Years","75 Years",{"count":104,"type":105},100,"ESTIMATED","OBSERVATIONAL","This is a prospective, multicenter, observational clinical study conducted under routine clinical practice conditions aimed at describing adherence to a creatine-based nutritional supplement (Creaticare FEM) in estrogen-depleted adult women. Participants will receive the supplement for 12 weeks, and adherence will be assessed as the percentage of doses consumed and the proportion of participants achieving ≥80% adherence. Secondary outcomes include persistence, satisfaction, tolerability, and adherence to recommended physical activity. Exploratory outcomes include changes in muscle strength, body composition, quality of life, joint pain, and skin health.",[109,110],"Menopause","Estrogen Deficiency",[112,109,113,114,115,116],"Creatine","Women´s Health","Estrogen deficiency","Collagen","Dietary supplements","2026-05-05",{"date":119,"type":120},"2026-05-12","ACTUAL",{"date":122,"type":120},"2026-03-20",{"date":124,"type":105},"2026-10-01",{"name":5,"class":6},4]