[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636727":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":10,"locations":24,"responsibleParty":45,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":10,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":10,"enrollmentInfo":58,"targetDuration":10,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"University of Rochester","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Rett Syndrome Participants",null,"Individuals with Rett syndrome who participate in this observational study will undergo a noninvasive electroencephalogram (EEG) recording while listening to simple sounds through headphones. Parents or caregivers will complete questionnaires and interviews related to the participant's symptoms, communication abilities, daily functioning and overall health. A Rett syndrome severity scale may also be completed by a clinician or trained member of the research team.",[13],"Procedure: Electroencephalogram (EEG) Recording",{"label":15,"type":10,"description":16,"interventionNames":17},"Age- and sex-matched controls","Individuals who are age- and sex-matched to Rett syndrome participants in this study will be enrolled as controls. Control participants must have no medical history of genetic, neurological, or psychiatric disorders, no history of special education services, and no hearing impairment. Control participants in this study will undergo a noninvasive electroencephalogram (EEG) recording while listening to simple sounds through headphones. Control participants (or their parent) will also complete a demographics questionnaire.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"PROCEDURE","Electroencephalogram (EEG) Recording","Participants will undergo a noninvasive electroencephalogram (EEG) recording to measure brain activity in response to auditory stimuli. During the procedure, participants will listen to simple sounds through headphones while brain signals are recorded. No behavioral responses are required.",[15,9],[25],{"facility":26,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Center for Advanced Brain Imaging and Neurophysiology, University of Rochester Medical Center","RECRUITING","Rochester","New York","14620","United States","US",{"type":34,"coordinates":35},"Point",[36,37],-77.61556,43.15478,{"lat":37,"lon":36},[40],{"name":41,"role":42,"phone":43,"phoneExt":10,"email":44},"Jamison Seabury, BS","CONTACT","315-663-4159","jamison_seabury@urmc.rochester.edu",{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","John Foxe","Professor - Department of Neuroscience (SMD)","100636727","auditory-eeg-and-behavioral-assessments-in-individuals-with-rett-syndrome-100636727",false,"NCT07569445","Auditory EEG and Behavioral Assessments in Individuals With Rett Syndrome","Rett Syndrome Participants:\n\nInclusion Criteria:\n\n* Have a clinical diagnosis of classic Rett syndrome\n* Have a pathogenic MECP2 genetic variant confirmed via genetic testing\n* Are past the clinical regression stage\n* Are within the eligible age range for the study (2 years or older)\n* Are able to tolerate the noninvasive EEG recording\n* Parent or caregiver is willing and able to provide parental permission and complete questionnaires and interviews\n\nExclusion Criteria:\n\n* Experiences hearing impairment or hearing loss\n* Presence of medical conditions that would prevent safe participation in EEG recording\n* Inability to tolerate EEG procedures\n* Any condition that in the opinion of the investigator would interfere with study participation or data quality\n\nControls\n\nInclusion Criteria:\n\n* Neurologically healthy individuals ages 2 years or older\n* Are able to tolerate the noninvasive EEG recording\n\nExclusion Criteria:\n\n* Experiences hearing impairment or hearing loss\n* Medical history of genetic, neurological, or psychiatric disorders\n* History of special education services\n* Inability to tolerate EEG procedures\n* Any condition that in the opinion of the investigator would interfere with study participation or data quality",true,"ALL","2 Years",{"count":59,"type":60},60,"ESTIMATED","OBSERVATIONAL","This observational research study is designed to learn more about how the brain processes sound in individuals with Rett syndrome. Participants will complete a noninvasive electroencephalogram (EEG) recording while listening to simple sounds through headphones. In addition, parents or caregivers will complete questionnaires and an interview about the participant's symptoms, communication abilities, daily functioning and overall health. The information collected from this study may help researchers better understand brain activity patterns and clinical features associated with Rett syndrome and support future research efforts.",[64],"Rett Syndrome",[66,67,68,69],"Electroencephalography","EEG","Brain activity","Biomarkers","2026-04-28",{"date":72,"type":73},"2026-05-06","ACTUAL",{"date":75,"type":73},"2025-07-31",{"date":77,"type":60},"2027-08",{"name":5,"class":6},1]