[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627980":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":10,"locations":29,"responsibleParty":52,"collaborators":10,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":74,"overallStatus":80,"whyStopped":10,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"BDH-Klinik Hessisch Oldendorf","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"UWS patients",null,"Patients classified as unresponsive wakefulness syndrome (UWS) with the Coma Recovery Scale-Revised (CRS-R)",[13,14],"Behavioral: Coma Recovery Scale-Revised (CRS-R)","Behavioral: Electroencephalography (EEG)",{"label":16,"type":10,"description":17,"interventionNames":18},"MCS patients","Patients classified as minimally conscious state (MCS) with the Coma Recovery Scale-Revised (CRS-R)",[13,14],[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"BEHAVIORAL","Coma Recovery Scale-Revised (CRS-R)","The Coma Recovery Scale-Revised (CRS-R) is a standardized behavioral assessment instrument used to determine the level of consciousness in patients with severe brain injury. It comprises six subscales evaluating auditory, visual, motor, oromotor\u002Fverbal, communication, and arousal functions, with hierarchically structured items to identify the highest level of behavioral responsiveness.",[16,9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Electroencephalography (EEG)","Electroencephalography (EEG) is a non-invasive neurophysiological method used to record spontaneous and stimulus-related electrical brain activity via scalp electrodes. In this study, bedside EEG recordings are performed using structured auditory stimulation paradigms designed to elicit event-related potentials (ERPs). These include hierarchical paradigms assessing different levels of auditory processing, ranging from basic sensory discrimination (e.g., mismatch negativity, MMN) to higher-order cognitive processing (e.g., N400 responses). EEG-derived ERP markers are analyzed to determine the highest detectable level of auditory processing and to evaluate their association with clinical diagnosis and long-term functional outcome.",[16,9],[30],{"facility":5,"status":10,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Hessisch Oldendorf","Lower Saxony","31840","Germany","DE",{"type":37,"coordinates":38},"Point",[39,40],9.24913,52.17269,{"lat":40,"lon":39},[43,48],{"name":44,"role":45,"phone":46,"phoneExt":10,"email":47},"Melanie Boltzmann, PhD","CONTACT","+49 5152781256","m.boltzmann@bdh-klinik-hessisch-oldendorf.de",{"name":49,"role":45,"phone":50,"phoneExt":10,"email":51},"Simone B. Jenner","+49 5152781215","s.jenner@bdh-klinik-hessisch-oldendorf.de",{"type":53,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100627980","auditory-processing-in-doc-patients-100627980",false,"NCT07455682","Auditory Processing in DOC Patients","Hierarchical Auditory Processing in Disorders of Consciousness: From Basic Deviance Detection to Semantic Integration","AUD-DOC","Inclusion Criteria:\n\n* Presence of a disorder of consciousness (Unresponsive Wakefulness Syndrome \\[UWS\\] or Minimally Conscious State \\[MCS\\]), classified using the Coma Recovery Scale-Revised (CRS-R) based on three assessments conducted on at least two separate days\n* Age between 18 and 80 years\n* Written informed consent provided by the patient's legal representative\n* Preserved brainstem auditory evoked potentials (BAEPs) on at least one side\n\nExclusion Criteria:\n\n* Ongoing sedation at the time of EEG assessment\n* Current treatment with medications known to significantly affect cortical functional state, including barbiturates, neuroleptics (antipsychotics), antiepileptic drugs, benzodiazepines, or comparable agents\n* Colonization with multidrug-resistant organisms requiring isolation precautions (e.g., 4MRGN)\n* Pregnancy\n* Impaired language comprehension (e.g., insufficient German language proficiency or aphasia)\n* Temporal bone fractures or severe infratentorial brain injury associated with unilateral or bilateral absence of auditory evoked potentials (AEPs)\n* Bilateral hearing impairment or deafness, or presence of a cochlear implant\n* Scalp wounds or conditions preventing placement of an EEG electrode cap","ALL","18 Years","80 Years",{"count":66,"type":67},42,"ESTIMATED","OBSERVATIONAL","This prospective observational study investigates whether electroencephalography (EEG) can improve the differentiation between unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) in patients with severe acquired brain injury. The study further examines the association between EEG markers of auditory processing and long-term functional outcome at 12 months.",[71,72,73],"Disorder of Consciousness","Unresponsive Wakefulness Syndrome","Minimally Conscious State",[75,26,76,22,77,78,79],"Disorders of Consciousness","Event-related potential (ERP)","Acquired Brain Injury","Critically ill patients","Neurological rehabilitation","NOT_YET_RECRUITING","2026-03-03",{"date":83,"type":84},"2026-03-06","ACTUAL",{"date":86,"type":67},"2026-04-15",{"date":88,"type":67},"2028-03-31",{"name":5,"class":6},1]