[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100515496":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":31,"locations":36,"responsibleParty":54,"collaborators":57,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":25,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":25,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":81,"overallStatus":39,"whyStopped":25,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Bakulev Scientific Center of Cardiovascular Surgery","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active TENS","ACTIVE_COMPARATOR","It will be performed attached to the tragus of the left ear.",[13],"Device: TENS",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham TENS","SHAM_COMPARATOR","It will be performed attached to the earlobe of the left ear.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","TENS","TENS will be performed from the moment of admission to the PCI, during the PCI and for the next 30 minutes after it.",[9,15],null,[27],{"name":28,"affiliation":29,"role":30},"Vladimir Shvartz, MD, DM","Bakoulev Scientific Center for Cardiovascular Surgery","PRINCIPAL_INVESTIGATOR",[32],{"name":28,"role":33,"phone":34,"phoneExt":25,"email":35},"CONTACT","+79032619292","vashvarts@bakulev.ru",[37],{"facility":38,"status":39,"city":40,"state":25,"zip":25,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Scientific Research Institute Ochapovsky Regional Clinical Hospital","RECRUITING","Krasnodar","Russia","RU",{"type":44,"coordinates":45},"Point",[46,47],38.98178,45.04534,{"lat":47,"lon":46},[50],{"name":51,"role":33,"phone":52,"phoneExt":25,"email":53},"Sofia Kruchinova, MD, PhD","+79189504597","skruchinova@mail.ru",{"type":30,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Vladimir A Shvartz, MD","MD, DM, Professor",[58],{"name":59,"class":6},"State Budget Public Health Institution Scientific Research Institute - Ochapovsky Regional Clinical Hospital","100515496","auricular-vagus-stimulation-and-stemi-100515496",false,"NCT05992259","Auricular Vagus Stimulation and STEMI","Auricular Vagus Stimulation and ST-Segment Elevation Myocardial Infarction","Inclusion Criteria:\n\n* patients with STEMI who have signed an informed voluntary consent to participate in the study;\n* primary myocardial infarction;\n* treatment in the first 12 hours from the onset of pain syndrome;\n* primary PCI.\n\nExclusion Criteria:\n\n* acute heart failure III-IV;\n* bradyarrhythmias;\n* atrial fibrillation\u002Fflutter at the time of switching on;\n* Thrombolytic therapy at the prehospital stage;\n* a history of myocardial infarction;\n* PCI\u002Fcoronary artery bypass grafting (CABG) in the anamnesis.","ALL","40 Years","75 Years",{"count":71,"type":72},300,"ESTIMATED","INTERVENTIONAL",[75],"NA","At the moment, the invasive strategy for the infarct-associated coronary artery in patients with ST-segment elevation myocardial infarction (STEMI) necessary to save the myocardium and reduce the size of the necrosis zone remains the leading one. However, despite the high efficiency of providing medical care to patients with acute coronary syndrome (ACS), there remains a high mortality and disability of this group of patients. In this regard, the search for new drug and non-drug strategies for the treatment of patients with ACS is actively continuing. Over the past decade, it has been shown that transcutaneous vagus nerve stimulation (TENS) has a cardioprotective effect both in chronic heart failure and in coronary heart disease, improves cardiac function, prevents reperfusion injury, weakens myocardial remodeling, increases the effectiveness of defibrillation and reduces the size of a heart attack. One of the methods of noninvasive stimulation of the afferent fibers of the vagus nerve is percutaneous electrical stimulation of the auricular branch of the vagus nerve. However, further studies are needed to determine whether stimulation of the tragus can improve the long-term clinical outcome in this cohort of patients.",[78,79,80],"Vagus Nerve Stimulation","Acute Coronary Syndrome","Ischemia Reperfusion Injury",[82,83,84,85,86,87,88,89,90,91,92],"auricular stimulation","auricular vagus nerve stimulation","transcutaneous vagus nerve stimulation (TENS)","vagus nerve stimulation (VNS)","acute coronary syndrome","myocardial ischemia reperfusion injury","ST-segment elevation myocardial infarction","coronary heart disease","acute myocardial infarction","mortality","atrial fibrillation","2025-06-17",{"date":95,"type":96},"2025-06-18","ACTUAL",{"date":98,"type":96},"2022-09-01",{"date":100,"type":72},"2026-12-01",{"name":5,"class":6},1]