[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100527460":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":13,"centralContacts":18,"locations":25,"responsibleParty":98,"collaborators":102,"id":114,"slug":115,"hasResults":116,"nctId":117,"briefTitle":118,"officialTitle":118,"acronym":10,"eligibilityCriteria":119,"healthyVolunteers":120,"sex":121,"minAge":122,"maxAge":10,"enrollmentInfo":123,"targetDuration":10,"studyType":126,"phases":10,"briefSummary":127,"conditions":128,"keywords":130,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":147},{"fullName":5,"class":6},"The University of New South Wales","OTHER",[8,11],{"label":9,"type":10,"description":10,"interventionNames":10},"CADASIL cohort",null,{"label":12,"type":10,"description":10,"interventionNames":10},"Control Cohort",[14],{"name":15,"affiliation":16,"role":17},"Perminder S Sachdev, MBBS, MD, PhD, FRANZCP, FAAHMS","University of New South Wales","PRINCIPAL_INVESTIGATOR",[19],{"name":20,"role":21,"phone":22,"phoneExt":23,"email":24},"Danit Saks, MBMSc, MRes, PhD","CONTACT","9348 1658","+612","d.saks@unsw.edu.au",[26,45,59,65,82],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"John Hunter Hospital","RECRUITING","Newcastle","New South Wales","2305","Australia","AU",{"type":35,"coordinates":36},"Point",[37,38],151.7801,-32.92953,{"lat":38,"lon":37},[41],{"name":42,"role":21,"phone":43,"phoneExt":23,"email":44},"Beata Bajorek, BPharm DipHospPharm PhD","4055 0650","Beata.Bajorek@newcastle.edu.au",{"facility":46,"status":28,"city":47,"state":30,"zip":48,"country":32,"countryCode":33,"cosmosGeoPoint":49,"geoPoint":53,"contacts":54},"Prince of Wales Hospital","Sydney","2031",{"type":35,"coordinates":50},[51,52],151.20732,-33.86785,{"lat":52,"lon":51},[55],{"name":56,"role":21,"phone":57,"phoneExt":58,"email":24},"Danit Saks, PhD","93481658","+61 2",{"facility":16,"status":28,"city":47,"state":30,"zip":48,"country":32,"countryCode":33,"cosmosGeoPoint":60,"geoPoint":62,"contacts":63},{"type":35,"coordinates":61},[51,52],{"lat":52,"lon":51},[64],{"name":56,"role":21,"phone":57,"phoneExt":58,"email":24},{"facility":66,"status":67,"city":68,"state":69,"zip":70,"country":32,"countryCode":33,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Royal Brisbane and Women's Hospital","NOT_YET_RECRUITING","Brisbane","Queensland","4006",{"type":35,"coordinates":72},[73,74],153.02809,-27.46794,{"lat":74,"lon":73},[77],{"name":78,"role":21,"phone":79,"phoneExt":80,"email":81},"Michael O'Sullivan, MD","3646 8111","+617","m.osullivan1@uq.edu.au",{"facility":83,"status":28,"city":84,"state":85,"zip":86,"country":32,"countryCode":33,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"Royal Melbourne Hospital","Melbourne","Victoria","3052",{"type":35,"coordinates":88},[89,90],144.96332,-37.814,{"lat":90,"lon":89},[93],{"name":94,"role":21,"phone":95,"phoneExt":96,"email":97},"Ashley Park, MD","9342 7000","+613","ashley.park@mh.org.au",{"type":99,"investigatorFullName":100,"investigatorTitle":101,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Perminder Sachdev","Professor",[103,106,107,109,110,112],{"name":104,"class":105},"Prince of Wales Hospital, Sydney","OTHER_GOV",{"name":27,"class":105},{"name":108,"class":6},"St Vincent's Hospital - Sydney, Australia",{"name":66,"class":105},{"name":111,"class":6},"Melbourne Health",{"name":113,"class":6},"The University of Queensland","100527460","auscadasil-an-australian-cohort-of-cadasil-100527460",false,"NCT06148051","AusCADASIL: An Australian Cohort of CADASIL","Inclusion criteria:\n\n1. Adults ≥18 years old\n2. Ability to provide written informed consent\n\n   * A large-print version is available for individuals with visual impairment\n   * An easy-to-read version is available for individuals with cognitive difficulties who may require extra support\n3. Ability to attend a testing site\n4. Ability to complete minimum dataset (medical examination and medical history questionnaire, blood test to determine genetic status and a short (20 minute) neuropsychology assessment).\n5. CADASIL participants according to one of the following categories:\n\n   1. confirmed diagnosis via genetic testing (NOTCH3 pathogenic variant), OR\n   2. suspected diagnosis based on medical history and brain MRI, OR\n   3. first degree relative of participant who is positive for NOTCH3 pathogenic variant\n\nOR 6. Unrelated individual who is negative for the NOTCH3 pathogenic variant, and has no cognitive complaints (i.e. control participant)\n\nExclusion criteria:\n\n1\\. Significant cognitive impairment leading to an inability to provide informed consent.",true,"ALL","18 Years",{"count":124,"type":125},300,"ESTIMATED","OBSERVATIONAL","The aim of this project is to establish an Australian cohort of patients diagnosed with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). This study will examine the clinical features and longitudinal course of CADASIL. Outcome measures include neuropsychological profile, neuroimaging, genetics, blood biomarkers, and retinal imaging.",[129],"Cadasil",[131,132,133,134,135,136,137],"CADASIL","Clinical Research","Genetics","Cognition","Neuroimaging","Blood markers","Retinal imaging","2024-05-07",{"date":140,"type":141},"2024-05-08","ACTUAL",{"date":143,"type":141},"2023-11-25",{"date":145,"type":125},"2027-03-31",{"name":100,"class":6},5]