[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100190563":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":20,"locations":26,"responsibleParty":99,"collaborators":20,"id":102,"slug":103,"hasResults":104,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":104,"sex":110,"minAge":111,"maxAge":20,"enrollmentInfo":112,"targetDuration":20,"studyType":115,"phases":116,"briefSummary":118,"conditions":119,"keywords":20,"overallStatus":29,"whyStopped":20,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":130},{"fullName":5,"class":6},"CHU de Quebec-Universite Laval","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"ACCE (Autologous Cultured Corneal Epithlium) graft for the treatment of corneal lesions","EXPERIMENTAL","Surgical transplantation of Autologous Cultured Corneal Epithelium",[13],"Procedure: Surgical transplantation of ACCE",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Surgical transplantation of ACCE","The culture of corneal epithelium strives to produce a reconstructed tissue with the therapeutical aim of treatment of limbal stem cell deficiency.",[9],null,[22],{"name":23,"affiliation":24,"role":25},"Ralph Kyrillos, MD FRCS (C)","CHU de Quebec","PRINCIPAL_INVESTIGATOR",[27,49,67,80],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"University Health Network - Toronto Western Hospital","RECRUITING","Toronto","Ontario","M5T 2S8","Canada","CA",{"type":36,"coordinates":37},"Point",[38,39],-79.39864,43.70643,{"lat":39,"lon":38},[42,47],{"name":43,"role":44,"phone":45,"phoneExt":46,"email":20},"Jennifer Coleman","CONTACT","416-340-4800","5389",{"name":48,"role":25,"phone":20,"phoneExt":20,"email":20},"Clara Chan, MD, FRCSC",{"facility":50,"status":29,"city":51,"state":52,"zip":53,"country":33,"countryCode":34,"cosmosGeoPoint":54,"geoPoint":58,"contacts":59},"CIUSSS de l'Est de l'île de Montréal","Montreal","Quebec","H1T 2M4",{"type":36,"coordinates":55},[56,57],-73.58781,45.50884,{"lat":57,"lon":56},[60,65],{"name":61,"role":44,"phone":62,"phoneExt":63,"email":64},"Dorline Sokoundjou, MSc","514-252-3400","7114","bfv2.hmr@ssss.gouv.qc.ca",{"name":66,"role":25,"phone":20,"phoneExt":20,"email":20},"Isabelle Brunette, MD",{"facility":68,"status":29,"city":51,"state":52,"zip":20,"country":33,"countryCode":34,"cosmosGeoPoint":69,"geoPoint":71,"contacts":72},"McGill University Health Centre; Centre de Médecine Innovatrice\u002FCentre for Innovative Medicine",{"type":36,"coordinates":70},[56,57],{"lat":57,"lon":56},[73,78],{"name":74,"role":44,"phone":75,"phoneExt":76,"email":77},"Natallia Barysevich, CRC\u002Fnurse","514-934-1934","22844","natallia.barysevich@muhc.mcgill.ca",{"name":79,"role":25,"phone":20,"phoneExt":20,"email":20},"Guillermo Rocha, MD, FRCSC",{"facility":81,"status":29,"city":82,"state":52,"zip":83,"country":33,"countryCode":34,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Centre universitaire d'Ophtalmologie CHU de Québec - HSS","Québec","G1S 4L8",{"type":36,"coordinates":85},[86,87],-71.21454,46.81228,{"lat":87,"lon":86},[90,93,98],{"name":23,"role":44,"phone":91,"phoneExt":20,"email":92},"418-682-7573","ralph.kyrillos.1@ulaval.ca",{"name":94,"role":44,"phone":95,"phoneExt":96,"email":97},"Lucie Germain, PhD","4185254444","61696","lucie.germain@fmed.ulaval.ca",{"name":23,"role":25,"phone":20,"phoneExt":20,"email":20},{"type":25,"investigatorFullName":100,"investigatorTitle":101,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Ralph Kyrillos","Principal Investigator","100190563","autologous-cultured-corneal-epithelium-ceca-for-the-treatment-of-limbal-stem-cell-deficiency-100190563",false,"NCT01756365","Autologous Cultured Corneal Epithelium (CECA) for the Treatment of Limbal Stem Cell Deficiency","Autologous Cultured Corneal Epithelium ( Culture d'épithélium cornéen Autologue CECA) for the Treatment of Unilateral Corneal Lesions Associated With Limbal Stem Cell Deficiency","CECA","Inclusion Criteria:\n\nAll genders\n\n* Adults\n* Minors\n* LSCD in one or two eyes. A minimum of 1-3 mm2 of undamaged limbus is required for a biopsy to be taken without foreseeable adverse consequences for the donor eye\n\nExclusion Criteria:\n\n* Donor eye not sufficiently healthy to allow for the harvesting of a 1-3 mm2 limbal biopsy without foreseeable consequences for the donor eye\n* Pregnancy\n* Breast-feeding\n* Incapacitated person\n* known allergy to aprotinine (Trasylol (R))\n* Hypersensibility to bovine proteins","ALL","1 Year",{"count":113,"type":114},54,"ESTIMATED","INTERVENTIONAL",[117],"NA","The study \" Autologous cultured corneal epithelium (CECA) for the treatment of corneal lesions associated with limbal stem cell deficiency\" is the first clinical trial of this product manufactured at the LOEX laboratory. The culture of corneal epithelium strives to produce a reconstructed tissue with the therapeutical aim of treatment of limbal stem cell deficiency. The study is a phase I\u002Fphase II study with the goal to evaluate safety and efficacy of the CECA graft for the treatment of human patients suffering from limbal stem cell deficiency.\n\nThe trial is open to all genders. The inclusion of 5 minors is planned.",[120],"Limbal Stem Cell Deficiency","2025-07-07",{"date":123,"type":124},"2025-07-10","ACTUAL",{"date":126,"type":20},"2012-12",{"date":128,"type":114},"2027-12",{"name":5,"class":6},4]