[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640017":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":31,"centralContacts":47,"locations":53,"responsibleParty":71,"collaborators":25,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":25,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":81,"minAge":82,"maxAge":25,"enrollmentInfo":83,"targetDuration":25,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":94,"overallStatus":56,"whyStopped":25,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Suez Canal University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ADDG Alone","EXPERIMENTAL","Participants in this arm will receive immediate implant placement in the maxillary premolar region with jumping gap filling using autologous demineralized dentin graft (ADDG) alone after extraction of non-restorable teeth. Clinical and radiographic evaluation will be performed during the follow-up period.",[13],"Procedure: Autologous Demineralized Dentin Graft",{"label":15,"type":10,"description":16,"interventionNames":17},"ADDG + Melatonin Gel","Participants in this arm will receive immediate implant placement in the maxillary premolar region with jumping gap filling using autologous demineralized dentin graft (ADDG) mixed with melatonin gel after extraction of non-restorable teeth. Clinical and radiographic evaluation will be performed during the follow-up period.",[18],"Drug: Melatonin gel",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Autologous Demineralized Dentin Graft","Autologous demineralized dentin graft prepared from extracted non-restorable teeth will be used for filling the jumping gap around immediately placed dental implants. Tooth preparation includes removal of restorations, caries, periodontal ligament, pulp tissue, calculus, and cementum, followed by grinding and demineralization using 2% nitric acid before graft placement.",[9],null,{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":25},"DRUG","Melatonin gel","Melatonin gel will be mixed with autologous demineralized dentin graft and used for filling the jumping gap around immediately placed dental implants in the maxillary premolar region to enhance osseointegration and peri-implant bone healing.",[15],[32,36,40,43],{"name":33,"affiliation":34,"role":35},"Hany Kamel Shalaby","Professor of Oral Medicine and Periodontology, Dean Faculty of Dentistry","STUDY_CHAIR",{"name":37,"affiliation":38,"role":39},"Shaima Mohammed Morsy","Assistant Professor of Oral Medicine and Periodontology","STUDY_DIRECTOR",{"name":41,"affiliation":42,"role":39},"Rasha El-Sayed Afifi","Lecturer of Oral Medicine and Periodontology",{"name":44,"affiliation":45,"role":46},"Abd El Fattah ELSaid Attia, B.S.D","B.S.D","PRINCIPAL_INVESTIGATOR",[48],{"name":49,"role":50,"phone":51,"phoneExt":25,"email":52},"B.S.D Abd El Fattah ELSaid Attia","CONTACT","+20100465932","PGS.230043@dent.suez.edu.eg",[54],{"facility":55,"status":56,"city":57,"state":25,"zip":25,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Suez Canal University, Faculty of Dentistry","RECRUITING","Ismailia","Egypt","EG",{"type":61,"coordinates":62},"Point",[63,64],32.27225,30.60427,{"lat":64,"lon":63},[67],{"name":68,"role":50,"phone":69,"phoneExt":25,"email":70},"Dean, Faculty of Dentistry, Suez Canal University","(+2064) 3223007","President_office@suez.edu.eg",{"type":46,"investigatorFullName":72,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Abd El Fattah ELSaid Attia Mowafy","100640017","autologous-demineralized-dentin-graft-with-or-without-melatonin-for-immediate-implant-osseointegration-100640017",false,"NCT07610876","Autologous Demineralized Dentin Graft With or Without Melatonin for Immediate Implant Osseointegration","Effect of Autologous Demineralized Dentin Graft With or Without Melatonin Gel on the Osseo Integration of Immediately Placed Implants: A Randomized Clinical Study","Inclusion Criteria:\n\n* Age above 20 years\n* Non-restorable maxillary premolar teeth\n* Candidates for immediate implant placement\n* Intact socket walls\n* Jumping gap \\>2 mm\n* Non-smokers or light smokers\n* No acute infection\n* Adequate bone for primary stability\n\nExclusion Criteria:\n\n* Heavy smokers\n* Bruxism or clenching\n* Uncontrolled systemic disease\n* Chemotherapy\u002Fradiotherapy\n* Immunocompromised patients",true,"ALL","20 Years",{"count":84,"type":85},16,"ESTIMATED","INTERVENTIONAL",[88],"NA","This randomized clinical study aims to evaluate the effect of autologous demineralized dentin graft (ADDG) with or without melatonin gel on the osseointegration of immediately placed dental implants in the maxillary premolar region. Sixteen patients requiring extraction and immediate implant placement will be randomly allocated into two groups. Clinical and radiographic outcomes including implant stability, peri-implant probing depth, modified bleeding index, marginal bone loss, buccal bone thickness, and bone density will be evaluated over a 9-month follow-up period.",[91,92,93],"Dental Implants","Immediate Implant Placement","Osseointegration",[95,96,97,98,93,99,100],"Melatonin","Dentin graft","Immediate implant","ADDG","CBCT","Dental implant stability","2026-05-20",{"date":103,"type":104},"2026-05-28","ACTUAL",{"date":106,"type":104},"2025-08-11",{"date":108,"type":85},"2026-11-10",{"name":5,"class":6},1]