[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639311":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":29,"collaborators":11,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":11,"eligibilityCriteria":39,"healthyVolunteers":35,"sex":40,"minAge":11,"maxAge":11,"enrollmentInfo":41,"targetDuration":11,"studyType":44,"phases":45,"briefSummary":47,"conditions":48,"keywords":11,"overallStatus":50,"whyStopped":11,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":11},{"fullName":5,"class":6},"Beijing Tiantan Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"PRP Patch (PP)","EXPERIMENTAL",null,[13],"Procedure: PRP Patch group",{"label":15,"type":16,"description":11,"interventionNames":17},"Whole blood patch (WP)","ACTIVE_COMPARATOR",[18],"Procedure: Whole Blood Patch Group",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"PROCEDURE","PRP Patch group","Autologous PRP was prepared with the 2-stage centrifugation method and mixed with iohexol contrast. We chose two separate sites for epidural access. A standard epidural puncture was conducted under the guidance of CT. The PRP mixture was titrated slowly into the epidural space and must be stopped immediately to patient's perception of backache or irradiating pain. A strict bed stay for 48 h was prescribed in supine position postoperatively.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Whole Blood Patch Group","Autologous whole blood was prepared and mixed with iohexol contrast. We chose two separate sites for epidural access. A standard epidural puncture was conducted under the guidance of CT. The whole blood mixture was titrated slowly into the epidural space and must be stopped immediately to patient's perception of backache or irradiating pain. A strict bed stay for 48 h was prescribed in supine position postoperatively.",[15],{"type":30,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Fang Luo","Professor","100639311","autologous-platelet-rich-plasma-versus-whole-blood-for-epidural-patch-in-spontaneous-intracranial-hypotension-100639311",false,"NCT07602556","Autologous Platelet-rich Plasma Versus Whole Blood for Epidural Patch in Spontaneous Intracranial Hypotension","Autologous Platelet-rich Plasma Versus Whole Blood for Epidural Patch in Spontaneous Intracranial Hypotension: A Multi-center, Prospective, Randomized Controlled Trial","Inclusion Criteria:\n\n* Informed consent to participate the research obtained from the patient\n* Satisfies the criteria for SIH according to the International Classification of Headache Disorders.\n\nExclusion Criteria:\n\n* There was concern for other causes of intracranial hypotension, such as postdural puncture, postsurgical and post-traumatic CSF leaks\n* Prior treatment with EBP at any time previously\n* Any contraindication to epidural puncture, such as space-occupying intracranial or intraspinal lesions, spinal defect, suspected infection over the puncture site, bleeding disorder and current anticoagulation therapy\n* History of drug and alcohol abuse, cognitive dysfunction, or mental illness\n* Unable to cooperate with postoperative evaluation, treatment, rehabilitation, and follow-up visits","ALL",{"count":42,"type":43},218,"ESTIMATED","INTERVENTIONAL",[46],"NA","Spontaneous intracranial hypotension (SIH) is a condition characterized by refractory orthostatic headache, mostly due to leaks of cerebrospinal fluid (CSF). Epidural patch with autologous platelet-rich plasma (PRP), which contains numerous growth factors and cytokines, has been reported as a new and promising alternative for current standard whole blood patching. However, there is no study comparing the efficacy and safety of the two approaches. In this study, we aimed to provide data concerning the outcomes of PRP patching versus conventional whole blood patching for treatment of refractory SIH cases failing in conservative therapy.",[49],"Spontaneous Intracranial Hypotension","NOT_YET_RECRUITING","2026-05-22",{"date":53,"type":54},"2026-05-27","ACTUAL",{"date":56,"type":43},"2026-05",{"date":58,"type":43},"2029-03",{"name":5,"class":6}]