[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621086":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":20,"responsibleParty":30,"collaborators":20,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":20,"eligibilityCriteria":39,"healthyVolunteers":40,"sex":41,"minAge":42,"maxAge":43,"enrollmentInfo":44,"targetDuration":20,"studyType":47,"phases":48,"briefSummary":50,"conditions":51,"keywords":20,"overallStatus":56,"whyStopped":20,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":20},{"fullName":5,"class":6},"Peking University Cancer Hospital & Institute","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Autologous Probiotics Transplantation","EXPERIMENTAL","Patients with defunctioning ileostomy following low anterior resection for rectal cancer, receive autologous probiotic (lactobacillus and bifidobacterium) after ileostomy closure.",[13],"Dietary Supplement: Autologous Probiotics",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIETARY_SUPPLEMENT","Autologous Probiotics","Patients with defunctioning ileostomy following low anterior resection for rectal cancer, receive autologous probiotics (lactobacillus and bifidobacterium) after ileostomy closure.\n\nAll patients will take a 100-day supply of high-activity autologous probiotic enteric-coated capsules (100 lactobacillus and 100 bifidobacterium enteric-coated capsules, 1 capsule per day, with each capsule containing a CFU activity of no less than 100 billion)",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Lin Wang","CONTACT","86-10-88196086","wanglinmd@foxmail.com",{"name":28,"role":24,"phone":20,"phoneExt":20,"email":29},"Jianning Zhai","jianningzhai@pku.edu.cn",{"type":31,"investigatorFullName":23,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","surgeon-in-charge","100621086","autologous-probiotics-in-patients-with-defunctioning-ileostomy-following-lar-for-rectal-cancer-100621086",false,"NCT07366047","Autologous Probiotics in Patients With Defunctioning Ileostomy Following LAR for Rectal Cancer","The Safety and Efficacy of Autologous Probiotics in Patients With Defunctioning Ileostomy Following Low Anterior Resection for Rectal Cancer.","Inclusion Criteria:\n\nAge: 18-80years old; Curative low anterior resection for rectal cancer with defunctioning ileostomy; ileostomy closure within 3-6 month; Preoperative chemoradiotherapy ; No evidence of anastomotic leakage or severe stenosis\n\nExclusion Criteria:\n\nTumor recurrence or distant metastasis; Secondary operation with stoma; Prior disease impairing bowel function except for rectal cancer; Any contraindication for transanal irrigation; Pregnant or nursing; Serious cardiovascular disease, uncontrolled infections, or other serious uncontrolled concomitant disease; Cognitive or psychological disorder;",true,"ALL","18 Years","80 Years",{"count":45,"type":46},40,"ESTIMATED","INTERVENTIONAL",[49],"NA","Rectal cancer patients who received low anterior resection combined with ileostomy may effectively reduce the probability of anastomotic leakage after surgery. However, due to the long-term semi-abandoned state of the distal colon, the probability of bowel dysfunction after ileostomy closure is very high. The incidence of low anterior resection syndrome (LARS) exceeds 70%, which is twice that of those who did not receive a preventive stoma. The main reasons include postoperative anatomical structure alteration, nerve damage, pathological changes of the colorectal mucosa, and gut microbiota variation, etc. The application of probiotics can significantly improve the bowel function of these patients. In this study, in order to enhance the colonization effect of probiotics, autologous probiotics will be applied to treat patients with defunctioning ileostomy. The primary outcome is the occurrence of major LARS after 6 months of the treatment.",[52,53,54,55],"Rectal Cancer","Gut Microbiomes","Autologous Probiotic Transplantation","Defunctioning Ileostomy","NOT_YET_RECRUITING","2026-01-18",{"date":59,"type":60},"2026-01-26","ACTUAL",{"date":62,"type":46},"2025-12-31",{"date":64,"type":46},"2027-12-31",{"name":5,"class":6}]