[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645251":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":40,"centralContacts":44,"locations":54,"responsibleParty":73,"collaborators":49,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":78,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":49,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":57,"whyStopped":49,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"University of California, San Francisco","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Data-driven adaptive DBS programming","EXPERIMENTAL","Patients receive adaptive deep brain stimulation delivered through the Medtronic Percept PC\u002FRC device, programmed with control parameters (sensing channel, detection thresholds, ramp rates, stimulation amplitude limits) recommended by the data-driven optimization pipeline and reviewed by a clinical researcher before programming. Stimulation amplitude is automatically adjusted between predefined upper and lower limits in response to sensed beta-band neural activity. Applied in counterbalanced 1-7 day blocks during awake hours in Session 6. These blocks will be randomized and counterbalanced for 40-60 days in patients' homes. Patients will be in cDBS mode overnight and will perform a blinded switch to either cDBS or aDBS upon waking in the morning.",[13,14],"Device: Medtronic Percept Deep Brain Stimulation (adaptive DBS)","Device: Medtronic Percept Deep Brain Stimulation (cDBS)",{"label":16,"type":17,"description":18,"interventionNames":19},"Open-loop continuous deep brain stimulation","ACTIVE_COMPARATOR","Participants with Parkinson's disease implanted with Percept and receiving open-loop deep brain stimulation.",[13,14],[21,30],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Medtronic Percept Deep Brain Stimulation (adaptive DBS)","Using the Percept pulse generator, patients receive adaptive stimulation to the subthalmaic nucleus.",[9,16],[27,28,29],"aDBS","adaptive DBS","adaptive deep brain stimulation",{"type":22,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"Medtronic Percept Deep Brain Stimulation (cDBS)","Using the Percept pulse generator, patients receive clinically-optimized open loop stimulation to the subthalmaic nucleus.",[9,16],[35,36,37,38,39],"deep brain stimulation","cDBS","continuous DBS","clinical DBS","continuous deep brain stimulation",[41],{"name":42,"affiliation":5,"role":43},"Simon Little, MBBS,PhD","PRINCIPAL_INVESTIGATOR",[45,51],{"name":46,"role":47,"phone":48,"phoneExt":49,"email":50},"Research Coordinator","CONTACT","5175152739",null,"sebastian.liu@ucsf.edu",{"name":52,"role":47,"phone":49,"phoneExt":49,"email":53},"Research Manager","sarah.wang@ucsf.edu",[55],{"facility":56,"status":57,"city":58,"state":59,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"University of California San Francisco","RECRUITING","San Francisco","California","94107","United States","US",{"type":64,"coordinates":65},"Point",[66,67],-122.41942,37.77493,{"lat":67,"lon":66},[70],{"name":71,"role":47,"phone":72,"phoneExt":49,"email":53},"Sarah Wang, PhD","415-353-7885",{"type":43,"investigatorFullName":74,"investigatorTitle":75,"investigatorAffiliation":5,"oldNameTitle":49,"oldOrganization":49},"Simon J. Little, MBBS, PhD","Assistant Professor, Clinical Neurology","100645251","automated-daytime-adaptive-deep-brain-stimulation-parameter-optimization-in-patients-implanted-with-percept-neurostimulator-100645251",false,"NCT07682311","Automated Daytime Adaptive Deep Brain Stimulation Parameter Optimization in Patients Implanted With Percept Neurostimulator","Auto aDBS","Inclusion Criteria:\n\n1. Age 25-75.\n2. Diagnosis of idiopathic PD.\n3. Patient has undergone surgical intervention with deep brain stimulation (Percept device) for their disorder at least 2 months prior to recruitment.\n4. Absence of significant cognitive impairment (score of 24 or greater on the Montreal Cognitive Assessment (MoCA)).\n5. Signed informed consent.\n6. Ability to comply with study follow-up visits for brain recording, testing of adaptive stimulation, and clinical assessment.\n7. Patient has been on cDBS for at least two months and still experiences significant residual motor fluctuation while on cDBS. Consequently, patient is undergoing aDBS treatment currently or was recommended aDBS as part of clinical care to manage their residual motor fluctuation.\n8. Has available cDBS Timeline LFP and stimulation data lasting at least 1 day.\n9. To be enrolled in the clinical trial phase of the study, patient will need to consent to reverting back to their baseline cDBS settings for all required cDBS testings.\n\nExclusion Criteria:\n\n1. Patient meets criteria for a psychogenic movement disorder.\n2. Significant untreated depression (BDI-II score \\>20). History of suicidal attempt or active suicidal ideation (Yes to #2-5 on C-SSRS).\n3. Any personality or mood symptoms that study personnel believe will interfere with study requirements.","ALL","25 Years","75 Years",{"count":87,"type":88},40,"ESTIMATED","INTERVENTIONAL",[91],"NA","Parkinson's disease (PD) affects \\~1% of people over 60 years old, is highly disabling and represents a large economic burden. While dopaminergic medications effectively treat motor symptoms early in the disease, most patients develop complications, including motor fluctuations and dyskinesias, which can be partially managed by deep brain stimulation (DBS). This surgical therapy consists of delivering continuous electrical stimulation through electrodes permanently implanted in basal ganglia nuclei, with a pulse generator and battery unit implanted in the chest. However, conventional DBS therapy is delivered with constant stimulation parameters, referred to as constant deep brain stimulation (cDBS), that are unresponsive to patient activities or to variations in the severity of symptoms during daily life. This leaves many patients under- or over-stimulated during parts of the day.\n\nTo address the shortcomings of cDBS, adaptive DBS (aDBS) uses real-time detection of neural signals to automatically adjust stimulation amplitude or other parameters in response to patients' dynamic clinical needs. aDBS was approved by the U.S. Food and Drugs Administration (FDA) for clinical treatment of PD in the Percept PC and RC (Medtronic) device in February 2025.\n\nFully leveraging this therapy in the real world is limited by technical challenges, in particular the fact that: while the investigators developed a consistent pipeline for implementing aDBS, there were several critical control parameters that strongly influenced algorithm performance and required prolonged trial-and-error based testing, to achieve successful control. In this new study, the investigators seek to significantly extend this work and address the major barriers to widespread, easy adoption of aDBS by groups without specialized knowledge of neurophysiology or feedback control. Here the investigators aim to test an automated, data-driven pipeline for the recommendation of the adaptive control parameters.",[94],"PD - Parkinson's Disease",[96,97,27,29,98,99,100,101],"DBS","adaptive","Medtronic Percept","Parkinson's Disease","PD","Percept","2026-06-26",{"date":104,"type":105},"2026-07-02","ACTUAL",{"date":107,"type":88},"2026-06",{"date":109,"type":88},"2032-05",{"name":5,"class":6},1]