[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570772":3},{"organization":4,"armGroups":7,"interventions":48,"overallOfficials":63,"centralContacts":71,"locations":80,"responsibleParty":100,"collaborators":102,"id":106,"slug":107,"hasResults":108,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":108,"sex":114,"minAge":115,"maxAge":116,"enrollmentInfo":117,"targetDuration":54,"studyType":120,"phases":121,"briefSummary":123,"conditions":124,"keywords":126,"overallStatus":83,"whyStopped":54,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":141},{"fullName":5,"class":6},"Seattle Institute for Biomedical and Clinical Research","OTHER",[8,16,20,24,28,32,36,40,44],{"label":9,"type":10,"description":11,"interventionNames":12},"Walking on 0% slope at self-selected speed","EXPERIMENTAL","All participants will walk on a treadmill, in a straight line, on a 0% slope, at their self-selected walking speed determined while walking overground.",[13,14,15],"Device: As-prescribed stiffness","Device: Two categories stiffer than the as-prescribed stiffness","Device: Two categories less stiff than the as-prescribed stiffness",{"label":17,"type":10,"description":18,"interventionNames":19},"Walking on 0% slope at 15% slower than self-selected speed","All participants will walk on a treadmill, in a straight line, on a 0% slope, at a speed that is 15% slower than their self-selected walking speed determined while walking overground.",[13,14,15],{"label":21,"type":10,"description":22,"interventionNames":23},"Walking on 0% slope at 15% faster than self-selected speed","All participants will walk on a treadmill, in a straight line, on a 0% slope, at a speed that is 15% faster than their self-selected walking speed determined while walking overground.",[13,14,15],{"label":25,"type":10,"description":26,"interventionNames":27},"Walking up an 8% slope at self-selected speed","All participants will walk on a treadmill, in a straight line, up an 8% slope, at their self-selected walking speed determined while walking overground up an 8% slope.",[13,14,15],{"label":29,"type":10,"description":30,"interventionNames":31},"Walking down an 8% slope at self-selected speed","All participants will walk on a treadmill, in a straight line, down an 8% slope, at their self-selected walking speed determined while walking overground up an 8% slope.",[13,14,15],{"label":33,"type":10,"description":34,"interventionNames":35},"Walking on 0% slope at self-selected speed while hand carrying a 5 kg load on their prosthetic side","All participants will walk on a treadmill, in a straight line, on a 0% slope, at their self-selected walking speed determined while walking overground, while carrying a 5 kg load in one hand on their prosthetic side.",[13,14,15],{"label":37,"type":10,"description":38,"interventionNames":39},"Walking on uneven terrain at self-selected speed","All participants will walk on an uneven terrain treadmill, in a straight line, on a 0% slope, at their self-selected walking speed determined while walking on the uneven terrain treadmill.",[13,14,15],{"label":41,"type":10,"description":42,"interventionNames":43},"Walking around a 2-meter diameter circle with the prosthesis on the inside of the circle","All participants will walk overground while following the outline of a 2-meter diameter circle, at their self-selected walking speed determined while walking around the circle, with their prosthetic limb on the inside of the circle.",[13,14,15],{"label":45,"type":10,"description":46,"interventionNames":47},"Walking around a 2-meter diameter circle with the prosthesis on the outside of the circle","All participants will walk overground while following the outline of a 2-meter diameter circle, at their self-selected walking speed determined while walking around the circle, with their prosthetic limb on the outside of the circle.",[13,14,15],[49,55,59],{"type":50,"name":51,"description":52,"armGroupLabels":53,"otherNames":54},"DEVICE","As-prescribed stiffness","A novel prosthesis that includes a low-profile prosthetic foot whose stiffness category is determined by the person's body weight and activity level (standard clinical practice).",[41,45,29,21,17,9,33,37,25],null,{"type":50,"name":56,"description":57,"armGroupLabels":58,"otherNames":54},"Two categories stiffer than the as-prescribed stiffness","A novel prosthesis that includes a low-profile prosthetic foot whose stiffness category is two categories stiffer than the as-prescribed stiffness.",[41,45,29,21,17,9,33,37,25],{"type":50,"name":60,"description":61,"armGroupLabels":62,"otherNames":54},"Two categories less stiff than the as-prescribed stiffness","A novel prosthesis that includes a low-profile prosthetic foot whose stiffness category is two categories less stiff than the as-prescribed stiffness.",[41,45,29,21,17,9,33,37,25],[64,68],{"name":65,"affiliation":66,"role":67},"Glenn Klute, PhD","US Department of Veterans Affairs","PRINCIPAL_INVESTIGATOR",{"name":69,"affiliation":70,"role":67},"Richard Neptune, PhD","The University of Texas at Austin",[72,77],{"name":73,"role":74,"phone":75,"phoneExt":54,"email":76},"Glenn K Klute, PhD","CONTACT","206-277-6792","Glenn.Klute@va.gov",{"name":78,"role":74,"phone":75,"phoneExt":54,"email":79},"Elise Campbell","Elise.Campbell@va.gov",[81],{"facility":82,"status":83,"city":84,"state":85,"zip":86,"country":87,"countryCode":88,"cosmosGeoPoint":89,"geoPoint":94,"contacts":95},"VA Puget Sound Healthcare System","RECRUITING","Seattle","Washington","98108","United States","US",{"type":90,"coordinates":91},"Point",[92,93],-122.33207,47.60621,{"lat":93,"lon":92},[96],{"name":97,"role":74,"phone":98,"phoneExt":54,"email":99},"Carlos Hernandez","206-764-2991","Carlos.Hernandez5@va.gov",{"type":101,"investigatorFullName":54,"investigatorTitle":54,"investigatorAffiliation":54,"oldNameTitle":54,"oldOrganization":54},"SPONSOR",[103],{"name":104,"class":105},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","NIH","100570772","automatic-prosthetic-foot-stiffness-modulation-to-improve-balance-100570772",false,"NCT06711588","Automatic Prosthetic Foot Stiffness Modulation to Improve Balance","Automatic Activity-Dependent and Phase-Varying Prosthetic Foot Stiffness Modulation to Improve Balance Control in Individuals With Lower-Limb Amputations","OSA","Inclusion Criteria:\n\n* Unilateral transtibial (below-knee) amputation\n* Been fit with a prosthesis and used it for at least 6 months\n* Wear the prosthesis for 4 or more hours on average per day\n* Be at least one-year post-amputation\n* Able to walk on a treadmill\n\nExclusion Criteria:\n\n* Presence of disorder, pain, or injury other than amputation that interferes with gait\n* Current skin irritation or injury on residual limb\n* Use of an assistive device for walking (cane, walker, etc.)","ALL","18 Years","70 Years",{"count":118,"type":119},20,"ESTIMATED","INTERVENTIONAL",[122],"NA","The goal of this clinical trial is to identify prosthesis stiffness that optimizes balance control in individuals with below knee amputations. The main question this clinical trial will answer is:\n\n• Is there an optimal stiffness that improves balance control for specific ambulatory activities and users? Participants will wear a novel prosthesis assembled with three prosthetic feet with a range of stiffness levels: each individual's clinically-prescribed foot stiffness and ± two stiffness categories. While wearing the study prostheses, participants will perform nine ambulatory activities of daily living (walking at different speeds, turning, ramp ascent\u002Fdescent, while carrying a load, and while walking on uneven terrain).",[125],"Lower Limb Amputation Below Knee",[127,128,129,130,131],"lower limb prosthesis","transtibial amputation","below knee amputation","biomechanics","gait","2026-05-11",{"date":134,"type":135},"2026-05-13","ACTUAL",{"date":137,"type":135},"2024-12-19",{"date":139,"type":119},"2026-08",{"name":5,"class":6},1]