[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593366":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":11,"centralContacts":33,"locations":42,"responsibleParty":64,"collaborators":11,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":11,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":11,"enrollmentInfo":77,"targetDuration":11,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":44,"whyStopped":11,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Rush University Medical Center","OTHER",[8,15,18,21],{"label":9,"type":10,"description":11,"interventionNames":12},"Adult Intensive Care Unit (AICU)","EXPERIMENTAL",null,[13,14],"Other: Pressure Support Ventilation (PSV)","Other: Automatic tube compensation (ATC)",{"label":16,"type":10,"description":11,"interventionNames":17},"Medical Intensive Care Unit (MICU)",[13,14],{"label":19,"type":10,"description":11,"interventionNames":20},"Cardiosciences Intensive Care Unit (CSICU)",[13,14],{"label":22,"type":10,"description":11,"interventionNames":23},"Neuroscience Intensive Care Unit (NSICU)",[13,14],[25,29],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Pressure Support Ventilation (PSV)","Spontaneous breathing trials will be conducted using the mode pressure support ventilation (PSV) with settings of a pressure support of 5 cmH2O and positive end expiratory pressure (PEEP) 5 cmH2O.",[9,19,16,22],{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":11},"Automatic tube compensation (ATC)","Spontaneous breathing trials will be conducted using the mode automatic tube compensation (ATC) with settings of 100% tube compensation and a positive end expiratory pressure (PEEP) of 5 cmH2O.",[9,19,16,22],[34,39],{"name":35,"role":36,"phone":37,"phoneExt":11,"email":38},"Jie Li, PhD","CONTACT","312-563-4643","Jie_Li@rush.edu",{"name":40,"role":36,"phone":11,"phoneExt":11,"email":41},"Lauren Harnois, MSc","Lauren_J_Harnois@rush.edu",[43],{"facility":5,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Chicago","Illinois","60612","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-87.65005,41.85003,{"lat":54,"lon":53},[57,60,62],{"name":35,"role":36,"phone":58,"phoneExt":11,"email":59},"3125634643","jie_li@rush.edu",{"name":61,"role":36,"phone":11,"phoneExt":11,"email":41},"Lauren Harnois, MS",{"name":61,"role":63,"phone":11,"phoneExt":11,"email":11},"SUB_INVESTIGATOR",{"type":65,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Jie Li","Professor","100593366","automatic-tube-compensation-vs-pressure-support-ventilation-during-spontaneous-breathing-trials-in-adults-100593366",false,"NCT07005505","Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Adults","Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Critically Ill Adults: A Cluster-Randomized, Cluster-Crossover Trial","Inclusion Criteria:\n\n* Admitted to intensive care unit (ICU)\n* Age 18 years or older\n* Requiring invasive mechanical ventilation for at least 24 hours\n* Pass spontaneous breathing trial screen criteria\n\nExclusion Criteria:\n\n* Clinical decision made not to proceed with extubation regardless of spontaneous breathing trial (SBT) results\n* Do not intubate (DNI) order\n* Presence of tracheostomy\n* Pregnancy\n* Known prisoner\n* Immediate need for extubation, self-extubation, or unplanned extubation that precludes safe performance of study procedures\n* Enrolled in another clinical trial that impacts ventilator weaning or liberation","ALL","18 Years",{"count":78,"type":79},880,"ESTIMATED","INTERVENTIONAL",[82],"NA","For patients requiring mechanical ventilation, spontaneous breathing trials (SBTs) are conducted to determine if it is safe to remove the breathing tube. There are multiple methods for conducting SBTs. The purpose of this study is to compare the effects of 2 methods, pressure support ventilation (PSV) versus automatic tube compensation (ATC), on successful extubation for critically ill adult patients who received mechanical ventilation for over 24 hours.",[85],"Spontaneous Breathing Trial in ICU",[87,88],"Ventilator liberation","Spontaneous breathing trial","2026-06-30",{"date":91,"type":92},"2026-07-02","ACTUAL",{"date":94,"type":92},"2025-06-01",{"date":96,"type":79},"2027-08",{"name":5,"class":6},1]