[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630037":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":24,"centralContacts":28,"locations":33,"responsibleParty":51,"collaborators":10,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":10,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":10,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"University Medical Centre Ljubljana","OTHER",[8,12,15,18,21],{"label":9,"type":10,"description":11,"interventionNames":10},"Healthy Young Adults",null,"Healthy volunteers aged 18-35 years without known cardiovascular disease.",{"label":13,"type":10,"description":14,"interventionNames":10},"Hypertension","Participants with arterial hypertension without orthostatic blood pressure abnormalities during orthostatic testing and without diabetes.",{"label":16,"type":10,"description":17,"interventionNames":10},"Hypertension With Orthostatic Hypotension","Participants with arterial hypertension and orthostatic hypotension identified during orthostatic testing.",{"label":19,"type":10,"description":20,"interventionNames":10},"Hypertension With Diabetes","Participants with arterial hypertension and coexisting diabetes.",{"label":22,"type":10,"description":23,"interventionNames":10},"Hypertension With Orthostatic Hypertension","Participants with arterial hypertension and orthostatic hypertension identified during orthostatic testing.",[25],{"name":26,"affiliation":5,"role":27},"Amela Kabaklić, MD, PhD","PRINCIPAL_INVESTIGATOR",[29],{"name":26,"role":30,"phone":31,"phoneExt":10,"email":32},"CONTACT","+386 1 522 43 05","amela.kabaklic@kclj.si",[34],{"facility":5,"status":35,"city":36,"state":10,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"RECRUITING","Ljubljana","1000","Slovenia","SI",{"type":41,"coordinates":42},"Point",[43,44],14.50513,46.05108,{"lat":44,"lon":43},[47,48],{"name":26,"role":30,"phone":31,"phoneExt":10,"email":32},{"name":49,"role":50,"phone":10,"phoneExt":10,"email":10},"Timur Mušić, MD","SUB_INVESTIGATOR",{"type":27,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Amela Kabaklić","MD, PhD, Specialist in Internal Medicine, Division of Internal Medicine, Department of Hypertension","100630037","autonomic-regulation-of-blood-pressure-and-heart-rate-during-orthostasis-and-exercise-in-healthy-and-hypertensive-individuals-100630037",false,"NCT07482462","Autonomic Regulation of Blood Pressure and Heart Rate During Orthostasis and Exercise in Healthy and Hypertensive Individuals","Assessment of Autonomic Regulation of Blood Pressure and Heart Rate in Healthy and Hypertensive Individuals During Orthostasis and Physical Exercise","Inclusion Criteria:\n\n* Healthy volunteers aged 18-35 years without known acute or chronic disease, non-smokers, body mass index (BMI) 20-24.9 kg\u002Fm², and negative orthostatic test\n* Participants aged ≥60 years with arterial hypertension followed at the Department of Hypertension\n* Hypertension group: controlled arterial hypertension, negative orthostatic test, without diabetes mellitus\n* Hypertension with orthostatic hypotension group: controlled arterial hypertension and positive orthostatic test indicating orthostatic hypotension\n* Hypertension with orthostatic hypertension group: controlled arterial hypertension and positive orthostatic test indicating a rise in blood pressure during orthostatic testing\n* Hypertension with diabetes mellitus group: controlled arterial hypertension and diabetes mellitus without previously diagnosed autonomic dysfunction\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Dementia, neurodegenerative disease, or cognitive impairment preventing understanding of study procedures\n* Known cardiovascular disease including heart failure (NYHA II-IV), myocardial infarction within the previous 6 months, clinically significant arrhythmias, or peripheral arterial occlusive disease\n* Uncontrolled arterial hypertension\n* Change in antihypertensive therapy within the previous 4 weeks\n* Presence of a cardiac pacemaker\n* Treatment with antiarrhythmic drugs (class I, III, or IV), digoxin, alpha-receptor blockers, or other medications known to significantly affect heart rate variability or autonomic function\n* Advanced renal failure (eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m²) or advanced liver failure\n* Active malignancy\n* Body mass index ≥35 kg\u002Fm²\n* Acute illness within the previous 4 weeks\n* Current smoking\n* Inability to safely perform exercise testing on a cycle ergometer\n* Severe psychiatric disorders without stable treatment\n* Pregnancy or breastfeeding\n* Participation in another clinical study\n* Refusal or inability to provide written informed consent",true,"ALL","18 Years",{"count":65,"type":66},120,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to assess arterial stiffness and autonomic regulation of blood pressure and heart rate in healthy adults and people with arterial hypertension during orthostatic stress and graded physical exercise. The main objective is to analyze cardiovascular responses to exercise on a cycle ergometer in different subgroups of participants with hypertension.\n\nThe study includes healthy young adults and older adults with hypertension. Participants undergo standardized assessments including orthostatic testing, graded exercise testing on a cycle ergometer, electrocardiography, and measurement of arterial stiffness parameters such as pulse wave velocity, as well as other vascular and hemodynamic parameters.\n\nThe results of this study are expected to improve understanding of cardiovascular physiology and autonomic regulation in people with hypertension and may contribute to earlier recognition of autonomic dysfunction and improved clinical management.",[13,70,71],"Autonomic Dysfunction","Orthostatic Hypotension",[73,74,75,76,77],"Orthostatic Test","Arterial Stiffness","Exercise Testing","Heart Rate Variability","Pulse Wave Velocity","2026-03-14",{"date":80,"type":81},"2026-03-19","ACTUAL",{"date":83,"type":81},"2025-10-15",{"date":85,"type":66},"2027-03",{"name":5,"class":6},1]