[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100396228":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":10,"centralContacts":47,"locations":53,"responsibleParty":69,"collaborators":10,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":10,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":10,"studyType":84,"phases":10,"briefSummary":85,"conditions":86,"keywords":10,"overallStatus":55,"whyStopped":10,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"University of Minnesota","OTHER",[8,17,21,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Aim 1: Postmenopausal Women",null,"Participants in this group are postmenopausal women.",[13,14,15,16],"Diagnostic Test: Microneurography to measure muscle sympathetic nerve activity (MSNA)","Diagnostic Test: Baroreflex sensitivity testing","Diagnostic Test: Sympathoexcitatory Maneuvers","Diagnostic Test: Blood tests",{"label":18,"type":10,"description":19,"interventionNames":20},"Aim 1: Premenopausal Women","Participants in this group are premenopausal women.",[13,14,15,16],{"label":22,"type":10,"description":23,"interventionNames":24},"Aim 2: Premature\u002FEarly Menopause","Participants in this group women who experienced premature or early menopause.",[13,14,15,16],{"label":26,"type":10,"description":27,"interventionNames":28},"Aim 2: Typical-Age Menopause","Participants in this group are women who experienced menopause at a typical age.",[13,14,15,16],[30,35,39,43],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"DIAGNOSTIC_TEST","Microneurography to measure muscle sympathetic nerve activity (MSNA)","Microneurography is a direct measurement of electrical activity of peripheral sympathetic nerves",[9,18,22,26],{"type":31,"name":36,"description":37,"armGroupLabels":38,"otherNames":10},"Baroreflex sensitivity testing","Two arms of the baroreflex that will be tested in this study are sympathetic and cardiovagal. Static baroreflex is tested during baseline resting conditions and dynamic baroreflex is tested during Valsalva maneuvers.",[9,18,22,26],{"type":31,"name":40,"description":41,"armGroupLabels":42,"otherNames":10},"Sympathoexcitatory Maneuvers","Cold Pressor Test (CPT) and Upper extremity fatiguing contraction with post exercise circulatory occlusion (PECO) will be performed",[9,18,22,26],{"type":31,"name":44,"description":45,"armGroupLabels":46,"otherNames":10},"Blood tests","Serum FSH, estrogen, progesterone, and testosterone will be measured",[9,18,22,26],[48],{"name":49,"role":50,"phone":51,"phoneExt":10,"email":52},"Manda Keller-Ross, PhD, DPT, PT","CONTACT","612-625-3175","kell0529@umn.edu",[54],{"facility":5,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"RECRUITING","Minneapolis","Minnesota","55455","United States","US",{"type":62,"coordinates":63},"Point",[64,65],-93.26384,44.97997,{"lat":65,"lon":64},[68],{"name":49,"role":50,"phone":51,"phoneExt":10,"email":52},{"type":70,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100396228","autonomic-regulation-of-blood-pressure-in-premature-and-early-menopausal-women-100396228",false,"NCT04439370","Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women","Inclusion Criteria:\n\n* Aged 35-49 or 50-70 years of age who experienced premature (\\\u003C40) or early (≤45) menopause\n* Premenopausal 35-49 years of age\n* Typical-age menopause (i.e., after 45 years of age), who are between 50-70 years old\n* Menopause will be confirmed by subject report of amenorrhea for 12 months and serum FSH of \\>30 mIU\u002FmL\n\nExclusion Criteria:\n\n* Current nicotine\u002Ftobacco use within the past six months\n* Are diabetic or asthmatic\n* Have diagnosed significant carotid stenosis\n* Have a history of significant autonomic dysfunction, heart disease, respiratory disease or a severe neurologic condition such as stroke or traumatic brain injury.\n* Have existing metabolic or endocrine abnormities\n* Take any heart\u002Fblood pressure medications that are determined to interfere with study outcomes\n* IF the participant is premenopausal AND currently taking OC or other exogenous steroids that are determined to interfere with study outcomes\n* Females who classify as having early or premature menopause AND are not willing to discontinue OC or MHT in order to complete the study\n* Are pregnant or breastfeeding",true,"FEMALE","35 Years","70 Years",{"count":82,"type":83},160,"ESTIMATED","OBSERVATIONAL","This is a cross-sectional study in which the investigators will determine the impact of premature\u002Fearly menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one and aim two.",[87,88,89,90],"Hypertension","Menopause, Premature","Menopause","Blood Pressure","2026-01-05",{"date":93,"type":94},"2026-01-08","ACTUAL",{"date":96,"type":94},"2019-10-01",{"date":98,"type":83},"2026-12-30",{"name":5,"class":6},1]