[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100386354":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":33,"centralContacts":38,"locations":46,"responsibleParty":64,"collaborators":66,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":71,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":83,"studyType":84,"phases":10,"briefSummary":85,"conditions":86,"keywords":10,"overallStatus":49,"whyStopped":10,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"RWTH Aachen University","OTHER",[8,14,18,22,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Postural Orthostatic Tachycardia Syndrome",null,"Patients with orthostatic intolerance because of Postural orthostatic tachycardia syndrome diagnosed in our outpatient clinic by tilt table examination.",[13],"Other: No intervention planned, but all patients get our standart treatment",{"label":15,"type":10,"description":16,"interventionNames":17},"Ehlers Danlos Syndrome","Patients with hypermobile or classical EDS who are already diagnosed including genetical testing for classical or vascular EDS and Marfan Syndromes",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Autoimmune autonomic neuropathy\u002FPure autonomic failure","Patients who have an autoimmune autonomic neuropathy based on clinical diagnosis and antibody testing in our outpatient clinic. Cardial MIBG Scintigraphy should have been performed.",[13],{"label":23,"type":10,"description":24,"interventionNames":10},"Healthy controls","Healthy controls with no documented cardiovascular or neurological disorders and no symtoms of autonomic failure\u002Fdizziness\u002Ffainting",{"label":26,"type":10,"description":27,"interventionNames":10},"others","Patients who have comorbidities as mast cell activation syndrome, chronic fatigue and\u002For Post COVID syndrome, based on clinical diagnosis in our outpatient clinic.",[29],{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":10},"No intervention planned, but all patients get our standart treatment","Patients are selected from clinical Routine and get our standart Treatment based on their disease",[19,15,9],[34],{"name":35,"affiliation":36,"role":37},"Andrea Maier","University Hospital, Aachen","PRINCIPAL_INVESTIGATOR",[39,44],{"name":40,"role":41,"phone":42,"phoneExt":42,"email":43},"Andrea Maier, physician","CONTACT","+492418089600","ans-ambulanz@ukaachen.de",{"name":45,"role":41,"phone":42,"phoneExt":42,"email":43},"Denver Igharo, student",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"University clinic RWTH Aachen","RECRUITING","Aachen","North Rhine-Westphalia","52074","Germany","DE",{"type":56,"coordinates":57},"Point",[58,59],6.08342,50.77664,{"lat":59,"lon":58},[62,63],{"name":40,"role":41,"phone":42,"phoneExt":42,"email":43},{"name":45,"role":41,"phone":42,"phoneExt":42,"email":43},{"type":37,"investigatorFullName":35,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Primary Investigator and attending physician",[67],{"name":68,"class":6},"DLR German Aerospace Center","100386354","autonomic-small-fiber-neuropathy-and-ehlers-danlos-syndromes---prospective-study-and-registry-100386354",false,"NCT04310644","Autonomic Small Fiber Neuropathy and Ehlers Danlos Syndromes - Prospective Study and Registry","Autonomic Neuropathy and Its Pathophysiology in Autoimmune Autonomic Neuropathies, Postural Orthostatic Tachycardia Syndrome and Ehlers Danlos Syndromes: Peripheral Autonomic Small Fiber Neuropathy or Central Autonomic Failure? Validation of the Malmö POTS Score and a Better Diagnosis of POTS in Patientes With Autnomic Failure (VaGeMAPS-3-step-Diag)","ProANS","Inclusion Criteria:\n\n* autonomic neuropathy\n* Postural orthostatic tachycardia syndrome\n* hypermobile or classical Ehlers Danlos syndromes\n* Chronic fatigue syndrome, mast cell activation syndrome and\u002For PostCOVID\n* healty controls\n* between 18-80 years\n* in patients: diagnosis and clinical testing in our outpatient clinic\n* German speaking\n\nExclusion Criteria:\n\n* pregnancy\n* Pacemaker or Deep brain Stimulation\n* sensory or motor Polyneuropathy\n* neurodegenerative disease","ALL","18 Years","80 Years",{"count":81,"type":82},200,"ESTIMATED","5 Years","OBSERVATIONAL","We examine patients with different autonomic neuropathies and Ehlers Danlos syndromes compared to healthy controls at three different points over time (baseline, after 3 months and after 1.5 years) to gain knowledge about the course of this disease and understand its pathophysiology, with a focus on Small Fiber neuropathy. Moreover we will validate the german version of the Malmö POTS Score and establish an easy diagnostic scheme for patients in outpatient care.",[87,88,89,90],"Autonomic Neuropathy","Ehlers-Danlos Syndrome Hypermobility Type","Small Fiber Neuropathy","Postural Tachycardia Syndrome","2025-02-03",{"date":93,"type":94},"2025-02-04","ACTUAL",{"date":96,"type":94},"2019-09-15",{"date":98,"type":82},"2029-09-15",{"name":5,"class":6},1]