[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100576025":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":25,"centralContacts":41,"locations":51,"responsibleParty":68,"collaborators":10,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":72,"sex":78,"minAge":79,"maxAge":10,"enrollmentInfo":80,"targetDuration":10,"studyType":83,"phases":10,"briefSummary":84,"conditions":85,"keywords":89,"overallStatus":54,"whyStopped":10,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Centre Hospitalier Universitaire de Nīmes","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Pregnant women developing placental vascular complications",null,"Pregnant adult women developing placental vascular complications such as preeclampsia and\u002For intrauterine growth retardation, hospitalized and delivering at Nimes University Hospital.",[13,14],"Diagnostic Test: Blood test","Diagnostic Test: Urine test",[16,21],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"DIAGNOSTIC_TEST","Blood test","16 blood samples (16 tubes, i.e. 55.3 ml) will be taken at inclusion. Pregnant women will be seen every month as part of their pregnancy follow-up, and blood (11 tubes, i.e. 35.5 ml) and urine samples will be taken at each follow-up visit.\n\nAt delivery, a systematic blood sample will be taken as part of the usual care, and an additional 11 tubes of blood (35.5 ml) will be taken.",[9],{"type":17,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"Urine test","Urine samples will be taken at the inclusion visit and at each follow-up visit.",[9],[26,29,31,33,35,37,39],{"name":27,"affiliation":5,"role":28},"Marie PORTES, Dr.","PRINCIPAL_INVESTIGATOR",{"name":30,"affiliation":5,"role":28},"Mathieu FORTIER, Dr.",{"name":32,"affiliation":5,"role":28},"Jean-Christophe GRIS, Pr.",{"name":34,"affiliation":5,"role":28},"Eve MOUSTY, Dr.",{"name":36,"affiliation":5,"role":28},"Vincent LETOUZEY, Dr.",{"name":38,"affiliation":5,"role":28},"Stéphanie HUBERLANT, Dr.",{"name":40,"affiliation":5,"role":28},"Chloé BOURGUIGNON, Dr.",[42,47],{"name":43,"role":44,"phone":45,"phoneExt":10,"email":46},"Sylvie BOUVIER, Dr.","CONTACT","+334.66.68.32.11","sylvie.bouvier@chu-nimes.fr",{"name":48,"role":44,"phone":49,"phoneExt":10,"email":50},"Anissa MEGZARI","+334 66 68 42 36","drc@chu-nimes.fr",[52],{"facility":53,"status":54,"city":55,"state":10,"zip":10,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Nimes University Hospital","RECRUITING","Nîmes","France","FR",{"type":59,"coordinates":60},"Point",[61,62],4.35788,43.83665,{"lat":62,"lon":61},[65],{"name":66,"role":44,"phone":67,"phoneExt":10,"email":46},"sylvie bouvier","0466686868",{"type":69,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100576025","autophagyapoptosis-balance-in-placental-vascular-pathologies-100576025",false,"NCT06779916","Autophagy\u002FApoptosis Balance in Placental Vascular Pathologies","Study of the Autophagy\u002FApoptosis Balance in Placental Vascular Pathologies","GROSSAUTOP-2","Inclusion Criteria:\n\n* Pregnant women developing a placental vascular complication (preeclampsia and\u002For intrauterine growth retardation), hospitalized and delivering at Nimes University Hospital.\n* Pregnant woman with free and informed consent.\n* Pregnant woman affiliated with and\u002For benefiting from a health insurance scheme.\n\nExclusion criteria:\n\n* Multiple pregnancy.\n* Presence of hypertension and\u002For proteinuria prior to pregnancy.\n* Participant in an interventional drug study.\n* Persons in a period of exclusion determined by another study.\n* Persons under court protection, guardianship or curatorship.\n* Persons unable to give consent.\n* Persons for whom it is impossible to give informed information.","FEMALE","18 Years",{"count":81,"type":82},50,"ESTIMATED","OBSERVATIONAL","Pregnancy increases the risk of thrombosis. Placenta-mediated diseases are a risk factor for cardiovascular pathologies and can lead to maternal-fetal morbidity and mortality. It is essential to understand the cellular and molecular mechanisms of dysfunctions at the vascular-placental interface so that systemic vascular risk can be characterized and, ultimately, screened for, on the basis of new markers (targeted preventive management).\n\nDeregulated autophagy could be the starting point for cell death by apoptosis or necrosis leading to complications.\n\nThe pathophysiological mechanisms involved in trophoblast apoptosis are incompletely described. This project follows on from the GrossAuTop-1 study, which investigated the intra- and inter-individual variability of autophagy and apoptosis activities in women during pregnancy. The aim of this project is to study autophagy and apoptosis activities specifically in women developing a placental vascular complication during pregnancy.",[86,87,88],"Pregnancy Complications","Pre-Eclampsia","Growth Retardation, Intrauterine",[90,91,92,93,94],"trophoblasts","autophagy","apoptosis","placenta","pregnancy","2026-04-30",{"date":97,"type":98},"2026-05-06","ACTUAL",{"date":100,"type":98},"2025-05-02",{"date":102,"type":82},"2029-05-01",{"name":5,"class":6},1]