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Its evolution is chronic, with flares and relapses, and the need for reliable biomarkers to be carried out routinely is major in patients' follow-up. Because of the existence of autoreactive immunoglobulins E (IgE) in autoimmune diseases, the recently described role for anti-Ro\u002FSSA antibodies in inducing interferon alpha (IFNα) signaling and the specific pharmacologic properties of IgE, anti-Ro\u002FSSA IgE should be an interesting biomarker to determine pSS's activity. The aim of the study is to evaluate whether the proportion of anti-Ro\u002FSSA IgE positive patients is higher in patients with active disease (i.e. Eular Sjögren Syndrome Disease Activity Index≥ 5). All consecutive patients with pSS (new or already known diagnosis) will be included, Anti-Ro\u002FSSA IgE titers will be determined, the disease's features will be collected (including Eular Sjögren Syndrome Disease Activity Index\u002FEular Sjogren's Syndrome Patient Reported Index).",[204],"Primary Sjögren's Syndrome",[206,207,208,209,210],"Sjögren's syndrome","Immunoglobulin E","Anti-Ro\u002FSSA","Autoimmune disease","Biomarker","2026-05-05",{"date":213,"type":214},"2026-05-06","ACTUAL",{"date":216,"type":214},"2018-03-27",{"date":218,"type":200},"2027-06",{"name":5,"class":6},8]