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Through comprehensive genomic profiling, investigators aim to identify the underlying genomic drivers of premalignant and malignant conditions across a range of disease stages and cancer types.\n\nComprehensive molecular profiling will include somatic tumor testing (tissue and\u002For blood) using next-generation sequencing. Selected subsets of samples may undergo whole exome and\u002For whole transcriptome sequencing for research purposes. Pharmacogenomic testing will also be performed to better understand individual variability in medication response and to identify opportunities for optimizing treatment. In addition, participants may optionally provide microbiome samples.\n\nTo maximize the value of the genomic data, participants who consent to this protocol will have their electronic health records-both retrospective and prospective-abstracted, curated, annotated, and linked to the genomic data generated through study testing. Given the long-term value of these data, participants may also voluntarily consent to the storage of their biological samples in a biobank and to the use of their de-identified information for future research.\n\nData collected from this participant population will support efforts to advance the understanding of cancer biology, as well as the discovery and validation of biomarkers associated with clinical outcomes. Findings may also be shared through collaborative research initiatives to further promote advancements in cancer research.",[113,114,115,116,117,118,119,120,121,122,123,124],"Cancer","Cancer Diagnosis","Early Detection of Cancer","Breast Cancer","Lung Cancer","Colon Cancer","GI Cancer","Gynecologic Cancer","Ovarian Cancer","Endometrial Cancer","CNS Cancer","Hematologic Cancer",[113,126,127,128,129],"Genomics","Genetics","Microbiome","Pharmacogenomics","2026-03-23",{"date":132,"type":133},"2026-03-27","ACTUAL",{"date":135,"type":133},"2021-11-01",{"date":137,"type":109},"2026-12-31",{"name":5,"class":6},6]