[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100569736":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":29,"locations":36,"responsibleParty":53,"collaborators":11,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":11,"enrollmentInfo":65,"targetDuration":11,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":78,"whyStopped":11,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Awake prone positioning","EXPERIMENTAL",null,[13],"Procedure: Awake prone positioning (APP)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"PROCEDURE","Awake prone positioning (APP)","* APP are realized following the diagnosis of ACS\n* Prone positioning or supine positioning are performed under supervision of a physician or a nurse\n* Maximum session duration: 16 hours per day\n* Sessions of prone positioning can be shortened, if necessary (30 minutes minimum), for better tolerance\n* Tolerance of prone positioning is assessed by the physician in charge and sessions and may be stopped in case of poor tolerance",[9],[21,24,27],{"name":22,"affiliation":5,"role":23},"Matthieu Turpin, MD","PRINCIPAL_INVESTIGATOR",{"name":25,"affiliation":5,"role":26},"Muriel Fartoukh, MD, PhD","STUDY_CHAIR",{"name":28,"affiliation":5,"role":26},"Alexandre Elabbadi, MD",[30,34],{"name":22,"role":31,"phone":32,"phoneExt":11,"email":33},"CONTACT","+33156016574","matthieu.turpin@aphp.fr",{"name":25,"role":31,"phone":32,"phoneExt":11,"email":35},"muriel.fartoukh@aphp.fr",[37],{"facility":38,"status":11,"city":39,"state":11,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Service de Médecine Intensive Réanimation TENON","Paris","75020","France","FR",{"type":44,"coordinates":45},"Point",[46,47],2.3488,48.85341,{"lat":47,"lon":46},[50,51],{"name":22,"role":31,"phone":32,"phoneExt":11,"email":33},{"name":52,"role":31,"phone":32,"phoneExt":11,"email":35},"Muriel FARTOUKH, MD, PhD",{"type":54,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100569736","awake-prone-positioning-for-severe-acute-chest-syndrome-100569736",false,"NCT06698120","Awake Prone Positioning for Severe Acute Chest Syndrome","Assessment of Efficacy and Safety of Awake Prone Positioning in Sickle Cell Anemia Patient Admitted in Intensive Care Unit for Severe Acute Chest Syndrome","PRONE-ACS","Inclusion Criteria:\n\n* Age \\>18 years\n* Major sickle cell anemia (SS, SC, Sβ)\n* Admission in intensive care unit for ACS\n* Registered in the French social insurance regime.\n* Written, informed consent\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women\n* Immediate need for intubation\n* Impaired vigilance status (Glasgow scale score \\\u003C 12)\n* Pneumothorax\n* Haemodynamically unstable\n* Thoracic trauma admission\n* Severely obese with body-mass index higher than 40 kg\u002Fm²\n* EIT contraindication: pacemaker, automatic implantable defibrillators, skin lesions facing the EIT belt, unstable rachis fracture or medullary lesions","ALL","18 Years",{"count":66,"type":67},15,"ESTIMATED","INTERVENTIONAL",[70],"NA","Acute chest syndrome (ACS) is the leading cause of admission to intensive care and the leading cause of death in patients with sickle cell disease. Irrespective of the cause of ACS, there is an heterogeneity in pulmonary ventilation\u002Fperfusion ratios, leading to worsening of the disease.\n\nEfficiency of awake prone positioning (APP) in acute respiratory failure (ARF) was particularly highlighted during the COVID-19 pandemic. Several physiological factors contribute to this benefit including an improvement in ventilatory drive and gas exchange.\n\nThe investigator hypothesize that APP could lead to clinical improvement in ACS in terms of oxygenation and ventilatory drive, by improving the heterogeneity of ventilation",[73,74],"Acute Chest Syndrome","Sickle Cell Anemia",[73,74,76,77],"Awake Prone Positioning","Electric Impedance","NOT_YET_RECRUITING","2025-08-25",{"date":81,"type":82},"2025-09-02","ACTUAL",{"date":84,"type":67},"2026-01",{"date":86,"type":67},"2027-08",{"name":5,"class":6},1]