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York and Scarborough Teaching Hospitals NHS Foundation Trust","York","YO31 8HE",{"type":56,"coordinates":1177},[1178,1179],-1.08271,53.95763,{"lat":1179,"lon":1178},[1182],{"name":1183,"role":44,"phone":27,"phoneExt":27,"email":27},"Bhavani Rengabashyam",{"type":41,"investigatorFullName":1185,"investigatorTitle":1186,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"Dr Amit Goyal","Consultant Oncoplastic Breast Surgeon & Associate Professor","100370878","axillary-management-in-breast-cancer-patients-with-needle-biopsy-proven-nodal-metastases-after-neoadjuvant-chemotherapy-100370878",false,"NCT04109079","Axillary Management in Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy","ATNEC - Axillary Management in T1-3N1M0 Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases at Presentation After Neoadjuvant Chemotherapy","ATNEC","Inclusion Criteria:\n\n* Age ≥ 18\n* Male or female\n* cT1-3N1M0 breast cancer at diagnosis (prior to NACT) as per AJCC 8th edition (see Section 6.4.1)\n\n  o Patients with occult primary invasive breast cancer (no identifiable invasive cancer in the breast) with FNA or core biopsy proven nodal metastases are eligible for the study.\n* FNA or core biopsy confirmed axillary nodal metastases at presentation\n* Oestrogen receptor and HER2 status evaluated on primary tumour\n* Received standard NACT as per local guidelines (Patients undergoing neoadjuvant endocrine therapy as part of another clinical trial are eligible)\n* Imaging of the axilla, as required, to assess response to NACT (per local guidelines)\n* Undergo a dual tracer sentinel node biopsy (SNB) after NACT with at least 3 nodes removed.\n\n  * If a single tracer SNB is performed: the patient is eligible only if the involved node is marked before or during NACT, and at least 3 nodes (including the marked node) are removed during sentinel node biopsy.\n  * If the node is not marked or the marked node is not removed: the patient is eligible only if the histology report shows evidence of down-staging with complete pathological response e.g., fibrosis or scarring in at least one node and at least 3 nodes removed.\n  * If fewer than 3 nodes are found on histology: the patient is eligible only if BOTH points a) and b), below, are met:\n\n    1. involved node was marked and removed during SNB; and\n    2. removed marked node shows evidence of downstaging on histology e.g. fibrosis or scarring.\n* If the sentinel node(s) cannot be localised on SNB: axillary node sampling should be performed, the patient will be eligible if at least 3 nodes are removed.\n* No evidence of nodal metastases post NACT (isolated tumour cells, micro or macro metastasis)\n* Patients with complete pathological response in the axilla but residual disease in the breast post NACT are eligible for the study\n* Patients who are cN0 (node negative) at initial presentation, with a negative sentinel node post NACT showing evidence of treatment response or downstaging will be eligible, provided at least 3 nodes are removed.\n\n5.2. Exclusion Criteria\n\nParticipants will be excluded if they have any one of the following:\n\n* Bilateral synchronous invasive breast cancer\n* Sentinel node biopsy prior to NACT\n* Previous axillary nodal surgery on the same body side as the scheduled targeted sampling\n* Any previous cancer within last 5 years or concomitant malignancy except\n\n  * basal or squamous cell carcinoma of the skin\n  * in situ carcinoma of the cervix\n  * in situ or stage 1 melanoma\n  * contra- or ipsilateral in situ breast cancer\n  * chronic lymphocytic leukaemia not on treatment","ALL","18 Years",{"count":1198,"type":1199},1900,"ESTIMATED","INTERVENTIONAL",[1202],"NA","The aim of this study is to assess whether, omitting further axillary treatment (ALND and ART) for patients with early stage breast cancer and axillary nodal metastases on needle biopsy, who after NACT have no residual cancer in the lymph nodes on sentinel node biopsy, is non-inferior to axillary treatment in terms of disease free survival (DFS) and results in reduced risk of lymphoedema at 5 years.",[1205,1206,1207],"Breast Cancer","Sentinel Lymph Node","Neoplasm, Breast",[1209,1210,1211,1212,1213,1214,1215,1216,1217,1218,1219],"neoadjuvant chemotherapy","sentinel node biopsy","breast cancer","tattooing node","marking node","clip node","axillary ultrasound","node positive","axillary lymph node dissection","axillary radiotherapy","axillary treatment","2026-03-27",{"date":1222,"type":1223},"2026-03-30","ACTUAL",{"date":1225,"type":1223},"2021-02-26",{"date":1227,"type":1199},"2030-02-28",{"name":5,"class":6},98]