[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100561620":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":10,"responsibleParty":21,"collaborators":23,"id":27,"slug":28,"hasResults":29,"nctId":30,"briefTitle":31,"officialTitle":31,"acronym":32,"eligibilityCriteria":33,"healthyVolunteers":29,"sex":34,"minAge":35,"maxAge":36,"enrollmentInfo":37,"targetDuration":10,"studyType":40,"phases":10,"briefSummary":41,"conditions":42,"keywords":46,"overallStatus":49,"whyStopped":10,"lastUpdateSubmitDate":50,"lastUpdatePostDateStruct":51,"startDateStruct":54,"completionDateStruct":56,"leadSponsor":58,"locationsCount":10},{"fullName":5,"class":6},"Alder Hey Children's NHS Foundation Trust","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Infants and children with Hirschsprung's Disease",null,"Children under the age of 7 years with Hirschsprung's Disease.",[13,18],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Rachel Harwood, FRCS PhD MRCS","CONTACT","+44 7709471898","rachel.harwood@alderhey.nhs.uk",{"name":19,"role":15,"phone":10,"phoneExt":10,"email":20},"Sarah Almond, FRCS (Paed)","Sarah.Almond@alderhey.nhs.uk",{"type":22,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[24],{"name":25,"class":26},"Bowel Research UK","UNKNOWN","100561620","babies-with-enterocolitis---a-study-of-faecal-calprotectin-in-hirschsprung-disease-the-beach-study-100561620",false,"NCT06592534","Babies With Enterocolitis - A Study of Faecal Calprotectin in Hirschsprung Disease (The BEACH Study)","BEACH","Inclusion criteria:\n\n\\- Any infant or child under the age of 5 years at the time of recruitment with biopsy proven Hirschsprung's Disease\n\nExclusion criteria:\n\n* Infants or children who do not have biopsy proven Hirschsprung's Disease\n* Individuals with total colonic Hirschsprung's Disease\n* Individuals with Hirschsprung's Disease which affects the small bowel\n* Children aged 5 years and over at the time of recruitment\n* Children with inflammatory bowel disease","ALL","0 Days","4 Years",{"count":38,"type":39},50,"ESTIMATED","OBSERVATIONAL","Babies with Hirschsprung's Disease are born without normal nerves to the end of their bowel which means they cannot poo properly, and are at high risk of infection of the bowel, called enterocolitis. 1 in 4 children with Hirschsprung's Disease develop enterocolitis and, if not treated quickly, it can lead to death. The symptoms include a swollen tummy, temperatures and diarrhoea but it can be hard to spot, especially in the early stages, and there is no test for it.\n\nIn some diseases, a substance called calprotectin is found in the poo when the bowel is inflamed. The investigators plan to collect poo samples from children with Hirschsprung's Disease and measure the calprotectin, to see if it can help the investigators predict which children are at highest risk of enterocolitis. When the investigators collect the poo we will ask parents some questions about their child's diet and poos over the week before, and how easy it was to collect the sample.\n\nThis is a pilot study, which means the investigators don't expect to get a definite answer to whether measuring calprotectin levels will change treatment for children with Hirschsprung's disease. However, it will help the investigators find out if calprotectin levels are a useful test for bowel inflammation in these children and will tell us what parents' views are on collecting poo samples regularly. If it does look like measuring calprotectin is a useful test in Hirschsprung's disease, the investigators will do more studies to find out if some children may benefit from more intensive treatment.",[43,44,45],"Hirschprung's Disease","Hirschsprung Disease","Hirschsprung's Disease Associated Enterocolitis",[47,48],"Faecal Calprotectin","Enterocolitis","NOT_YET_RECRUITING","2024-09-13",{"date":52,"type":53},"2024-09-19","ACTUAL",{"date":55,"type":39},"2024-10",{"date":57,"type":39},"2026-10",{"name":5,"class":6}]