[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618294":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":38,"locations":30,"responsibleParty":44,"collaborators":30,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":30,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":30,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":71,"whyStopped":30,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":30},{"fullName":5,"class":6},"Fujian University of Traditional Chinese Medicine","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Group for Traditional Chinese Medicine Pentatonic Sound Therapy","EXPERIMENTAL","Therapeutic Protocol for 'Five-Tone' Therapy Based on Melodic Intonation Training Model: Subjects undergo syndrome differentiation and treatment, with corresponding 'Five-Tone' melodies selected for active training based on the melodic intonation intervention model. Intervention duration: All eligible participants in this study received four weeks of treatment, administered once daily for 40 minutes, five days per week.",[13],"Other: Traditional Chinese Medicine Five-Tone Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Melodic Intonation Therapy Treatment Group","ACTIVE_COMPARATOR","Melodic intonation training. Intervention duration: All eligible participants enrolled in this study received treatment for 4 weeks, once daily for 40 minutes, with sessions conducted 5 days per week.",[19],"Other: Melodic Intonation Training",{"label":21,"type":16,"description":22,"interventionNames":23},"Conventional control group","① Rehabilitation training: Physicians conduct limb movement and speech rehabilitation training for participants in accordance with the Clinical Evidence-Based Practice Guidelines for Integrated Traditional and Western Medicine Rehabilitation of Stroke (2024 Edition). ② Conventional Medical Management: Standard foundational treatment is administered to enrolled subjects in accordance with the National Health Commission's Guidelines for the Prevention and Treatment of Cerebrovascular Diseases (2024 Edition). This encompasses: management of underlying causes, blood pressure control, antiplatelet therapy, anticoagulant therapy, and regulation of blood glucose and lipid levels. ③ Health Education: Health education is provided to subjects to raise awareness of the severe risks associated with stroke and the available rehabilitation interventions.",[24],"Other: Standard speech therapy; Routine medical treatment; Health education",[26,31,35],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Traditional Chinese Medicine Five-Tone Therapy","Therapeutic Protocol for 'Five-Tone' Therapy Based on Melodic Intonation Training Model: Subjects undergo syndrome differentiation and treatment, with corresponding 'Five-Tone' melodies selected. Based on the melodic intonation training model, active training is conducted through melodic intervention measures. ① Rehabilitation training② Conventional Medical Management.③ Health Education:",[9],null,{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Melodic Intonation Training","All eligible participants enrolled in the study received four weeks of melodic intonation therapy, administered once daily for 40 minutes, five days per week.① Rehabilitation training② Conventional Medical Management.③ Health Education:",[15],{"type":6,"name":36,"description":22,"armGroupLabels":37,"otherNames":30},"Standard speech therapy; Routine medical treatment; Health education",[21],[39],{"name":40,"role":41,"phone":42,"phoneExt":30,"email":43},"Jia Huang, Doctor","CONTACT","+8659188529125","jasmine1874@163.com",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Ruiming Nan","Professor","100618294","based-on-the-spatio-temporal-coding-characteristics-of-frontotemporal-network-this-paper-explores-the-mechanism-of-five-tone-speech-training-in-reshaping-language-fluency-function-100618294",false,"NCT07329751","Based on the Spatio-temporal Coding Characteristics of Frontotemporal Network, This Paper Explores the Mechanism of Five-tone Speech Training in Reshaping Language Fluency Function.","Eligibility Criteria\n\nInclusion Criteria:\n\nAge between 18 and 70 years\n\nRight-handed\n\nNative Chinese speakers\n\nClinical diagnosis of post-stroke aphasia caused by ischemic stroke, confirmed by CT or MRI\n\nDiagnosis of non-fluent aphasia based on the Western Aphasia Battery (WAB), with BDAE severity rating of 1-5\n\nTime since stroke onset ≥ 2 weeks\n\nStable vital signs, clear consciousness, and no severe cognitive impairment\n\nAbility to understand the study procedures and provide written informed consent (or consent provided by a legally authorized representative)\n\nExclusion Criteria:\n\nHistory of aphasia or neurological disease not caused by stroke (e.g., traumatic brain injury, brain tumor, neurodegenerative diseases)\n\nSevere visual or auditory impairments that would interfere with task performance\n\nSevere cognitive impairment or disorders of consciousness preventing cooperation with language assessment or intervention\n\nSevere dysarthria or apraxia of speech that precludes valid language assessment\n\nHistory of epilepsy or other severe neurological conditions\n\nSevere systemic diseases (e.g., severe cardiopulmonary dysfunction, renal failure, hepatic failure, malignancy)\n\nPsychiatric disorders (e.g., schizophrenia, severe depression, or other major psychiatric illnesses)\n\nContraindications to MRI or fNIRS assessment (e.g., metallic implants, severe claustrophobia)",true,"ALL","18 Years","80 Years",{"count":59,"type":60},120,"ESTIMATED","INTERVENTIONAL",[63],"NA","To explore the mechanism of five-tone speech training in reshaping language fluency function and the clinical efficacy of aphasia language function, daily communication ability and communication efficiency based on the temporal and spatial coding characteristics of frontotemporal network. Combined with EEG ( rsEEG, ERP ), nuclear magnetic resonance examination and near-infrared imaging system examination to explore its effect on brain electrophysiological activity. So as to promote the modernization of traditional Chinese medicine rehabilitation treatment technology and the popularization and application of speech rehabilitation treatment technology.",[66],"Aphasia",[68,69,70],"aphasia","stroke","pentatonic scales of chinese medicine","NOT_YET_RECRUITING","2026-01-19",{"date":74,"type":75},"2026-01-21","ACTUAL",{"date":77,"type":60},"2025-12-31",{"date":79,"type":60},"2028-09-30",{"name":5,"class":6}]