[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644269":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":39,"centralContacts":44,"locations":53,"responsibleParty":68,"collaborators":34,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":34,"enrollmentInfo":81,"targetDuration":34,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":93,"overallStatus":56,"whyStopped":34,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Fundacion Miguel Servet","OTHER",[8,14,20,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo Control Group","PLACEBO_COMPARATOR","Participants receive a placebo (nitrate-depleted beetroot juice) and continue with their usual daily activities without any additional intervention.",[13],"Dietary Supplement: Placebo group: nitrate-depleted beetroot juice",{"label":15,"type":16,"description":17,"interventionNames":18},"Beetroot Extract Supplementation","EXPERIMENTAL","Participants receive daily supplementation with beetroot extract juice and continue with their usual daily activities.",[19],"Dietary Supplement: Beetroot Extract Supplementation",{"label":21,"type":16,"description":22,"interventionNames":23},"Beetroot Extract Plus Multicomponent Exercise","Participants engage in a multicomponent physical exercise program, supervised during the first 6 weeks and then prescribed but not supervised for the following 6 weeks, combined with daily supplementation of beetroot extract juice.",[19],{"label":25,"type":26,"description":27,"interventionNames":28},"Placebo Plus Multicomponent Exercise","ACTIVE_COMPARATOR","Participants engage in a multicomponent physical exercise program, supervised during the first 6 weeks and then prescribed but not supervised for the following 6 weeks, combined with placebo supplementation (nitrate-depleted beetroot juice).",[13],[30,35],{"type":31,"name":15,"description":32,"armGroupLabels":33,"otherNames":34},"DIETARY_SUPPLEMENT","Participants receive daily supplementation with beetroot extract juice, with or without participation in a multicomponent physical exercise program, depending on group allocation. When applicable, the exercise program targets strength, balance, mobility, and aerobic capacity, and is supervised by trained professionals during the first 6 weeks and subsequently prescribed but not supervised for the following 6 weeks. This intervention aims to evaluate the independent and combined effects of beetroot extract supplementation and physical exercise on cardiovascular, functional, and cognitive outcomes in adults aged 75 years and older.",[21,15],null,{"type":31,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"Placebo group: nitrate-depleted beetroot juice","Participants receive daily supplementation with nitrate-depleted beetroot juice, with or without participation in a multicomponent physical exercise program, according to group allocation. The placebo juice is derived from beetroot but has had its nitrate content removed, maintaining similar appearance, taste, and texture to the active supplement. When applicable, the exercise program targets strength, balance, mobility, and aerobic capacity and is supervised by trained professionals during the first 6 weeks, followed by a prescribed but unsupervised phase for the subsequent 6 weeks. This placebo-controlled intervention is designed to isolate the effects of dietary nitrate from beetroot extract and to evaluate the independent and combined effects of physical exercise on cardiovascular, functional, and cognitive outcomes in adults aged 75 years and older.",[9,25],[40],{"name":41,"affiliation":42,"role":43},"Nicolas Martinez-Velilla, MD-PhD","Navarrabiomed-Fundación Miguel Servet-Hospital Universitario de Navarra","PRINCIPAL_INVESTIGATOR",[45,50],{"name":46,"role":47,"phone":48,"phoneExt":34,"email":49},"Nicolas Martinez-Velilla, Md-PhD","CONTACT","00 34 848422222","nicolas.martinez.velilla@navarrra.es",{"name":51,"role":47,"phone":48,"phoneExt":34,"email":52},"Fabricio Zambom-Ferraresi, PhD","fabricio.zambom.ferraresi@navarra.es",[54],{"facility":55,"status":56,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":34},"Hospital Universitario de Navarra","RECRUITING","Pamplona","Navarre","31008","Spain","ES",{"type":63,"coordinates":64},"Point",[65,66],-1.64323,42.81687,{"lat":66,"lon":65},{"type":69,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR","100644269","beetroot-extract-and-quality-of-life-in-adults-aged-75-and-over-100644269",false,"NCT07666685","Beetroot Extract and Quality of Life in Adults Aged 75 and Over","Assessment of the Benefits of Beetroot Extract for Improving the Quality of Life of Older People: a Randomised Clinical Trial.","BERS","Inclusion Criteria:\n\n1. Adults aged 75 years and older recruited from the Geriatrics Service of the Hospital Universitario de Navarra (HUN) or primary care settings.\n2. Ability to ambulate independently.\n3. Ability to communicate effectively.\n4. Ability to tolerate physical exercise.\n5. Barthel Index score greater than 60 points.\n\nExclusion Criteria:\n\n1. Refusal or inability of the participant, caregiver, or legal guardian to provide written informed consent.\n2. Advanced or severe dementia (Global Deterioration Scale \\[GDS\\] stages 6-7).\n3. Unstable medical condition or terminal illness with a life expectancy of less than 6 months.\n4. Ischemic heart disease or congestive heart failure.\n5. Severe renal insufficiency.\n6. Hypotension.",true,"ALL","75 Years",{"count":82,"type":83},120,"ESTIMATED","INTERVENTIONAL",[86],"NA","The increasing number of adults aged 75 years and older highlights the need for effective, low-cost interventions to preserve cardiovascular health, functional independence, and cognitive performance and to support healthy aging. Beetroot extract (BE), derived from \"Beta vulgaris\", contains high levels of inorganic nitrate and other bioactive compounds that may positively influence vascular and neuromuscular function. In parallel, multicomponent physical exercise is recognized as an effective strategy to improve physical and cognitive outcomes in older adults. However, evidence on the independent and combined effects of BE supplementation and structured exercise in very old adults remains limited.\n\nThis randomized controlled trial is designed to evaluate the effects of BE supplementation, alone and in combination with a multicomponent physical exercise program, on blood pressure, functional performance, and cognitive function in adults aged 75 years and older. Participants will be randomly assigned to one of four groups: BE supplementation, multicomponent exercise, combined BE supplementation and exercise, or a control condition, over a predefined intervention period. The exercise program will include strength, balance, mobility, and aerobic components specifically adapted to the abilities and safety requirements of old adults.\n\nThe primary outcomes of the study will assess changes in cardiovascular health, physical and functional performance, and cognitive function using standardized and validated assessment tools. Secondary outcomes will include additional indicators of physical capacity and health-related quality of life. This trial aims to provide clinically relevant evidence on whether BE supplementation, alone or in combination with multicomponent exercise, represents a practical and scalable intervention to improve cardiovascular, functional, and cognitive health in adults aged 75 years and older.",[89,90,91,92],"Cardiovascular Health","Functional Health","Cognitive Function Decline","Physical Performance Decline in Older Adults",[94,95,96,97,98,99],"beetroot extract","dietary nitrate","cardiovascular health","functional health","quality of life","cognitive function","2026-06-26",{"date":102,"type":103},"2026-06-30","ACTUAL",{"date":105,"type":103},"2026-03-24",{"date":107,"type":83},"2027-11",{"name":5,"class":6},1]