[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100365660":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":36,"centralContacts":41,"locations":47,"responsibleParty":64,"collaborators":67,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":29,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":29,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":29,"overallStatus":50,"whyStopped":29,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Hugo W. Moser Research Institute at Kennedy Krieger, Inc.","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Cognitive Fatigue","EXPERIMENTAL","We will use a behavioral intervention. Participants will perform a cognitively demanding task, repeatedly, to induce cognitive fatigue.",[13],"Behavioral: Cognitive Fatigue",{"label":15,"type":10,"description":16,"interventionNames":17},"Physical Fatigue","We will use a behavioral intervention. Participants will perform a physically demanding task (grip force exertion task), repeatedly, to induce cognitive fatigue.",[18],"Behavioral: Physical Fatigue",{"label":20,"type":10,"description":21,"interventionNames":22},"Rewarding Stimuli","We will use a behavioral intervention. Reward-associated stimuli will be used to study how reward-induced changes in motivational state influence effort choices.",[23],"Behavioral: Rewarding Stimuli",[25,30,33],{"type":26,"name":9,"description":27,"armGroupLabels":28,"otherNames":29},"BEHAVIORAL","Participants will perform a cognitively demanding task (spatial attention task), repeatedly, to induce cognitive fatigue.",[9],null,{"type":26,"name":15,"description":31,"armGroupLabels":32,"otherNames":29},"Participants will perform a physically demanding task (grip force exertion task), repeatedly, to induce cognitive fatigue.",[15],{"type":26,"name":20,"description":34,"armGroupLabels":35,"otherNames":29},"Reward-associated stimuli will be used to study how reward-induced changes in motivational state influence effort choices.",[20],[37],{"name":38,"affiliation":39,"role":40},"Vikram S. Chib, PhD","Kennedy Krieger Institute and Johns Hopkins School of Medicine","PRINCIPAL_INVESTIGATOR",[42],{"name":43,"role":44,"phone":45,"phoneExt":29,"email":46},"Anthony Gonzalez","CONTACT","443-923-2716","gonzalezan@kennedykrieger.org",[48],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Kennedy Krieger Institute","RECRUITING","Baltimore","Maryland","21209","United States","US",{"type":57,"coordinates":58},"Point",[59,60],-76.61219,39.29038,{"lat":60,"lon":59},[63],{"name":43,"role":44,"phone":45,"phoneExt":29,"email":46},{"type":40,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"Vikram Chib","Assistant Professor; Research Scientist",[68],{"name":69,"class":70},"National Institute of Mental Health (NIMH)","NIH","100365660","behavioral-and-neural-representations-of-subjective-effort-cost-100365660",false,"NCT04041154","Behavioral and Neural Representations of Subjective Effort Cost","Inclusion Criteria:\n\n* Right-handed\n* Age between 18 and 35 years old - Male or female\n* Any ethnicity\n\nExclusion Criteria:\n\nIndividuals with a history of any of the following will be excluded from the study:\n\n* Neurological problems such as stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease (self- report)\n* Diagnosed history of severe psychiatric disease such as depression, schizophrenia (self-report)\n* Metal in the head or eyes\n* If they are pregnant or suspect that you may be pregnant\n* If they experience discomfort from the MRI scan, such as severe claustrophobia or excessive heating of tattoos",true,"ALL","18 Years","35 Years",{"count":82,"type":83},185,"ESTIMATED","INTERVENTIONAL",[86],"NA","The goal of this proposal is to understand the common and distinct behavioral and neural representations of subjective effort valuation, and how these representations are influenced by fatigue and changes in motivation. It is hypothesized that the brain will use overlapping and distinct neural circuits to represent cognitive and physical effort value, and that fatigue and enhanced motivation will influence the subjective value of effort.",[89],"Fatigue","2026-01-23",{"date":92,"type":93},"2026-01-26","ACTUAL",{"date":95,"type":93},"2018-08-01",{"date":97,"type":83},"2029-12-31",{"name":5,"class":6},1]