[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100452656":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":23,"locations":28,"responsibleParty":46,"collaborators":18,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":51,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":18,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":31,"whyStopped":18,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"UConn Health","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"HFpEF patients","EXPERIMENTAL","HFpEF patient who are currently taking beta blockers",[13],"Other: beta blocker discontinuation",[15],{"type":6,"name":16,"description":16,"armGroupLabels":17,"otherNames":18},"beta blocker discontinuation",[9],null,[20],{"name":21,"affiliation":5,"role":22},"Kai Chen, MD,PhD","PRINCIPAL_INVESTIGATOR",[24],{"name":21,"role":25,"phone":26,"phoneExt":18,"email":27},"CONTACT","860-679-3343","kachen@uchc.edu",[29],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"UConn Health \u002F John Dempsey Hospital","RECRUITING","Farmington","Connecticut","06030","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-72.83204,41.71982,{"lat":41,"lon":40},[44],{"name":45,"role":25,"phone":26,"phoneExt":18,"email":27},"Kai Chen, MD, PhD",{"type":22,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Christopher Pickett","Associate Professor","100452656","beta-blocker-discontinuation-in-heart-failure-with-preserved-ejection-fraction-100452656",false,"NCT05174351","Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction","Effect of Beta-blocker Discontinuation on Functional Capacity and Cardiac Hemodynamics in Patients With Heart Failure With Preserved Ejection Fraction","HFpEF-BB","Inclusion Criteria:\n\n* Stable HFpEF patients with NYHA Class II-III or elevated BNP ≥100\n* N=30 (Target: 30).\n* Age: 50 \\~ 80 years.\n* ECHO evidence of EF ≥50% and Grade 2 or 3 diastolic dysfunction.\n* Chronic loop diuretic use\n* Currently on beta-blocker\n\nExclusion Criteria:\n\n* Beta blocker was prescribed for treating other cardiac conditions such as atrial fibrillation or coronary artery disease.\n* Heart rate \\> 100 bpm\n* Recent hospitalization due to HF within 3 months\n* Non-English speaker","ALL","50 Years","80 Years",{"count":61,"type":62},30,"ESTIMATED","INTERVENTIONAL",[65],"NA","This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.",[68],"Heart Failure With Preserved Ejection Fraction",[70,71,72,73],"HFpEF","Beta-blocker","echocardiogram","6MWT","2025-09-23",{"date":76,"type":77},"2025-09-29","ACTUAL",{"date":79,"type":77},"2021-12-20",{"date":81,"type":62},"2027-11-01",{"name":5,"class":6},1]