[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100587006":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":13,"locations":19,"responsibleParty":33,"collaborators":7,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":39,"acronym":40,"eligibilityCriteria":41,"healthyVolunteers":37,"sex":42,"minAge":43,"maxAge":44,"enrollmentInfo":45,"targetDuration":48,"studyType":49,"phases":7,"briefSummary":50,"conditions":51,"keywords":57,"overallStatus":63,"whyStopped":7,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},{"fullName":5,"class":6},"Universitair Ziekenhuis Brussel","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","Completion of questionnaires; child psychiatric screening; faecal sample analysis","Completion of questionnaires:\n\n* FFQ (Food Frequency Questionnaire) - completed by child\n* KIDSCREEN-10 - completed by child\n* CRIES-13 (Child Revised Impact of Events Scale) - completed by parents\u002Fguardian and child\n* CTES (Childhood Trust Events Survey) - completed by parents\u002Fguardian\n* RCADS-25 (Revised Children's Anxiety and Depression Scale) - completed by parents\u002Fguardian and child\n\nChild psychiatric screening using SCID-5-Junior - semi-structured interview conducted with child and parent(s)\u002Fguardian\n\nFaecal sample analysis:\n\n* Beta-diversity (UniFrac and Bray-Curtis distance index)\n* Firmicutes\u002FBacteroidetes ratio\n* Abundance of Prevotella, Lactobacillaceae, Bifidobacteriacae and Lachnospiraceae\n* Short-chain fatty acid metabolites",[14],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},"Sam L.B. Bonduelle, Master of Medicine","CONTACT","+32 2 474 97 27","sam.bonduelle@uzbrussel.be",[20],{"facility":21,"status":7,"city":22,"state":23,"zip":24,"country":25,"countryCode":26,"cosmosGeoPoint":27,"geoPoint":32,"contacts":7},"UZ Brussel","Jette","Brussels Capital","1090","Belgium","BE",{"type":28,"coordinates":29},"Point",[30,31],4.33419,50.87309,{"lat":31,"lon":30},{"type":34,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100587006","between-the-belly-and-the-brain-distorted-gut-brain-crosstalk-in-early-life-adversity-100587006",false,"NCT06922773","Between the Belly and the Brain: Distorted Gut-brain Crosstalk in Early-life Adversity","BellyBrain","Inclusion Criteria:\n\n* Primary school-aged children (6 to 13 years of age) who have experienced at least one early-life traumatic event, based on the Childhood Trust Events Survey (CTES) questionnaire\n* The child and at least one of his\u002Fher parents (or guardian) speak Dutch sufficiently well to complete all of the questionnaires and the semi-structured child psychiatric interview (SCID-5-Junior)\n\nExclusion Criteria:\n\n* any chronic disorders or diseases known to affect the gut micobiome\n* inablity to complete questionnaires and\u002For semi-structured interview because of linguistic and\u002For cognitive barrier\n* congenital or acquired immunodeficiencies\n* use of medication(s) that affect gastrointestinal function (e.g., antibiotics) within the last 6 weeks, or laxatives within the last 4 weeks, or probiotic or prebiotic supplements within the last 4 weeks\n* current involvement in another clinical or food study","ALL","6 Years","13 Years",{"count":46,"type":47},50,"ESTIMATED","1 Month","OBSERVATIONAL","The goal of this observational study is to learn about the effects of early-life adversity (ELA) on the composition of children's microbiome and on their psychosocial functioning. The main questions it aims to answer are:\n\n* Do children who have experienced ELA have lower gut microbial diversity and\u002For an altered gut microbial composition?\n* Do these microbiome alterations correlate with adverse neurodevelopmental outcomes, including increased levels of stress, social and\u002For affective problems?",[52,53,54,55,56],"Early Life Adversity","Microbiome, Human","Anxiety Symptoms","Depressive Symptoms","Posttraumatic Stress Symptoms",[58,59,60,61,62],"early life adversity","gut microbiome","anxiety symptoms","depressive symptoms","posttraumatic stress symptoms","NOT_YET_RECRUITING","2025-04-03",{"date":66,"type":67},"2025-04-10","ACTUAL",{"date":69,"type":47},"2025-05",{"date":71,"type":47},"2026-06",{"name":5,"class":6},1]