[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100231592":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":20,"centralContacts":24,"locations":34,"responsibleParty":102,"collaborators":104,"id":107,"slug":108,"hasResults":109,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":19,"eligibilityCriteria":113,"healthyVolunteers":109,"sex":114,"minAge":115,"maxAge":19,"enrollmentInfo":116,"targetDuration":19,"studyType":119,"phases":120,"briefSummary":122,"conditions":123,"keywords":127,"overallStatus":37,"whyStopped":19,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":142},{"fullName":5,"class":6},"Imperial College London","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Patients with pelvic recurrence from primary colorectal cancer","Implementation of imaging assessment proformas describing anatomic pelvic compartments and aetiology of disease recurrence for treatment planning.",[12],"Procedure: New Radiological Staging Classification system for patients with advanced and recurrent colorectal cancer undergoing pelvic exenterative surgery",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"PROCEDURE","New Radiological Staging Classification system for patients with advanced and recurrent colorectal cancer undergoing pelvic exenterative surgery","Currently there are no validated criteria or guidelines for judging whether advanced primary or recurrent colorectal cancer can be successfully removed and for selecting which patients should undergo this form of more radical surgery as is exenterative surgery. We are proposing that by validating the detailed evaluation of imaging of the tumour distribution within the pelvis using a new radiological staging classification, this will enable clear selection criteria to be established and will improve surgical planning.",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Gina Dr Brown, MD","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":19,"email":29},"Caroline Martin","CONTACT","+44 (0) 7749 655 817","c.martin1@imperial.ac.uk",{"name":31,"role":27,"phone":32,"phoneExt":19,"email":33},"Syvella Ellis","+44 (0) 7732 315 234","giclinicaltrials@imperial.ac.uk",[35,54,72,88],{"facility":36,"status":37,"city":38,"state":19,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Oslo University Hospital","RECRUITING","Oslo","N-0424","Norway","NO",{"type":43,"coordinates":44},"Point",[45,46],10.74609,59.91273,{"lat":46,"lon":45},[49,52],{"name":50,"role":27,"phone":19,"phoneExt":19,"email":51},"Arne Solbakken","ARMSOL@ous-hf.no",{"name":53,"role":23,"phone":19,"phoneExt":19,"email":19},"Kjersti Flatmark",{"facility":55,"status":37,"city":56,"state":57,"zip":19,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"St Mark's Hospital","Harrow","London","United Kingdom","UK",{"type":43,"coordinates":61},[62,63],-0.33208,51.57835,{"lat":63,"lon":62},[66,69],{"name":67,"role":27,"phone":19,"phoneExt":19,"email":68},"Ian Jenkins","i.jenkins@nhs.net",{"name":70,"role":27,"phone":19,"phoneExt":19,"email":71},"Pooja Datt","pooja.datt@nhs.net",{"facility":73,"status":37,"city":74,"state":75,"zip":19,"country":58,"countryCode":59,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Churchill Hospital","Oxford","Oxfordshire",{"type":43,"coordinates":77},[78,79],-1.25596,51.75222,{"lat":79,"lon":78},[82,85],{"name":83,"role":27,"phone":19,"phoneExt":19,"email":84},"Chris Cunningham","Chris.Cunningham@ouh.nhs.uk",{"name":86,"role":27,"phone":19,"phoneExt":19,"email":87},"Madeleine Thyssen","Madeleine.Thyssen@ouh.nhs.uk",{"facility":89,"status":37,"city":90,"state":19,"zip":91,"country":58,"countryCode":59,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"Royal Marsden Hospital NHS Foundation Trust","Sutton","SM2 5PT",{"type":43,"coordinates":93},[94,95],-0.2,51.35,{"lat":95,"lon":94},[98,100],{"name":99,"role":27,"phone":19,"phoneExt":19,"email":33},"Cordelia Grant",{"name":101,"role":23,"phone":19,"phoneExt":19,"email":19},"Christos Kontovounisios, MD",{"type":103,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR",[105],{"name":106,"class":6},"Pelican Cancer Foundation","100231592","beyond-tme-origins-100231592",false,"NCT02292641","Beyond TME Origins","Investigating the Origins of Pelvic Recurrence in Colorectal Cancer","Inclusion Criteria:\n\n1. Had a primary colorectal adenocarcinoma proven by biopsy taken as part of routine clinical practice\n2. Has a confirmed diagnosis of recurrent pelvic colorectal cancer\n3. Has previously completed surgical treatment of primary adenocarcinoma of the colon, sigmoid colon or rectum\n4. Are able to undergo high resolution MRI for staging prior to treatment decisions\n5. Have provided written informed consent to participate in the study\n6. Be aged 16 years or over\n\nExclusion Criteria:\n\n1. Have irresectable extra-pelvic metastatic disease\n2. Original baseline staging and preoperative restaging scans (MR for rectal and sigmoid cancers and\u002For CT for colon and sigmoid cancers) are unavailable\n3. Original preoperative, surgical and adjuvant treatment has not been documented or is unavailable","ALL","16 Years",{"count":117,"type":118},383,"ESTIMATED","INTERVENTIONAL",[121],"NA","All patients with recurrent colorectal cancer in the pelvis are eligible. The original primary tumour staging scans and resected surgical specimen needs to be available. Patients' recurrence will be staged using our proposed MRI classification. We will be assessing the original primary staging scans and histopathology to learn about risk factors for recurrence. We will record treatment for the recurrence, and patients will be followed up for three years.",[124,125,126],"Neoplasms","Adenocarcinoma","Carcinoma",[128,129,130,131,132,124,125,126],"Lower Gastrointestinal Tract","Rectum","Diagnostic Imaging","Magnetic Resonance Imaging","Pelvic Exenteration","2024-10-16",{"date":135,"type":136},"2024-10-17","ACTUAL",{"date":138,"type":136},"2014-09-25",{"date":140,"type":118},"2031-12",{"name":5,"class":6},4]