[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586503":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":32,"locations":38,"responsibleParty":53,"collaborators":55,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":24,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":24,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":80,"overallStatus":41,"whyStopped":24,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"University of California, San Francisco","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Long Term Memory","ACTIVE_COMPARATOR","Multi-session cognitive intervention as a computer game that presents an adaptive spatial wayfinding challenge.",[13],"Behavioral: Long Term Memory",{"label":15,"type":10,"description":16,"interventionNames":17},"Worder","Multi-session cognitive intervention as a computer game that presents a word puzzle.",[18],"Behavioral: Worder",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","Tablet computer game designed to stimulate environmental enrichment via an adaptive and immersive experience learning virtual neighborhoods and errands in order to complete assigned errands.",[9],null,{"type":21,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"Tablet computer game designed to stimulate interest in solving word puzzles, much like the Boggle game.",[15],[29],{"name":30,"affiliation":5,"role":31},"Peter E Wais, PhD","PRINCIPAL_INVESTIGATOR",[33],{"name":34,"role":35,"phone":36,"phoneExt":24,"email":37},"Melissa Arioli, AB","CONTACT","(415) 502-7321","bid.core@ucsf.edu",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":24},"University of California, San Francsico","RECRUITING","San Francisco","California","94158","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-122.41942,37.77493,{"lat":51,"lon":50},{"type":54,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[56],{"name":57,"class":58},"National Institute on Aging (NIA)","NIH","100586503","bid-ltm-digital-intervention-in-aging-100586503",false,"NCT06916221","BID LTM Digital Intervention in Aging","Behavioral Intervention Development Core - Long Term Memory Digital Intervention in Aging","Inclusion Criteria:\n\n* Minimum of 12 years of education\n* English fluency: All task instructions are presented in English language text. In order to control for sufficient and equivalent participant comprehension of the procedures and instructions, we require their self-report of fluency in English.\n* Normal or corrected-to-normal vision\n* Normal or corrected-to-normal hearing\n* Medically healthy older adults, including those with below-average cognitive performance \u002FMCI patients without dementia referred by neuropsychologists (i.e., no participant medical records will be reviewed).\n\nExclusion Criteria:\n\n* Under the age of 60\n* Clinical diagnosis of neurological or psychiatric disorder Clinical diagnosis of dementia or AD8 score of \\>4\n* Visually or hearing impaired without correction to normal\n* Regularly (one or more times per week) practicing an instrument within the last year\n* 10 years or more of formal musical instrument training","ALL","60 Years","85 Years",{"count":70,"type":71},150,"ESTIMATED","INTERVENTIONAL",[74],"NA","Healthy aging is typically accompanied by diminished capability for learning and retrieval of high-fidelity long-term memory (LTM). The decline in these faculties is accelerated and becomes significant deficits in LTM and cognitive control functions at the level or a diagnosis of Mild Cognitive Impairment (MCI). Training with the navigation game, relative to training with control games, is expected to improve LTM performance for older adult participants.\n\nResearchers will compare two different digital interventions to assess whether they may be helpful in improving cognitive function.\n\nParticipants will conduct study activities remotely (e.g., at-home):\n\n1. Baseline Assessment. Complete a series of cognitive assessments and surveys.\n2. Intervention. Engage in a digital intervention for up to 8 weeks.\n3. Post Intervention Assessment. Complete the same cognitive assessments and surveys as the Baseline Assessment.\n4. Follow-Up Assessment. Six months after the intervention ends, participants will complete the same cognitive assessments and surveys as the Baseline Assessment.",[77,78,79],"Long-Term Memory","Inhibitory Control","Mild Cognitive Impairment",[81,82,83],"cognitive training","cognitive aging","memory","2026-03-31",{"date":86,"type":87},"2026-04-02","ACTUAL",{"date":89,"type":87},"2025-08-20",{"date":91,"type":71},"2028-07-31",{"name":5,"class":6},1]