[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100597559":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":42,"responsibleParty":60,"collaborators":63,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":25,"eligibilityCriteria":72,"healthyVolunteers":69,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":25,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":45,"whyStopped":25,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"The University of Texas Health Science Center, Houston","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active rTMS stimulation","ACTIVE_COMPARATOR","Participants will receive active H-coil delivered rTMS in each treatment visit for up to 20 treatment visits for about 4 weeks. In each visit, there are three rTMS sessions with inter-rTMS-session interval of about 30 minutes.",[13],"Device: Active rTMS stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham rTMS stimulation","SHAM_COMPARATOR","Participants will receive sham H-coil delivered rTMS in each treatment visit for up to 20 treatment visits for about 4 weeks. In each visit, there are three rTMS sessions with inter-rTMS-session interval of about 30 minutes.",[19],"Device: Sham rTMS stimulation",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Active H-coil delivered rTMS sessions will be given three times per treatment visit for up to 20 visits for about 4 weeks. There are about 30 minutes breaks between adjacent TMS sessions. Each TMS session takes about 3 to 4 minutes to complete.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Sham H-coil delivered rTMS sessions will be given three times per treatment visit for up to 20 visits for about 4 weeks. There are about 30 minutes breaks between adjacent TMS sessions. Each TMS session takes about 3 to 4 minutes to complete.",[15],[30],{"name":31,"affiliation":5,"role":32},"Xiaoming Du, PhD","PRINCIPAL_INVESTIGATOR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},"Alina Siatka","CONTACT","713-486-2740","Alina.Siatka@uth.tmc.edu",{"name":31,"role":36,"phone":40,"phoneExt":25,"email":41},"443-882-9717","Xiaoming.Du@uth.tmc.edu",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"The University of Texas Health Science Center at Houston","RECRUITING","Houston","Texas","77030","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-95.36327,29.76328,{"lat":55,"lon":54},[58],{"name":31,"role":36,"phone":59,"phoneExt":25,"email":41},"713-486-2700",{"type":32,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Xiaoming Du","Assistant Professor",[64],{"name":65,"class":66},"National Institute of Mental Health (NIMH)","NIH","100597559","bilateral-prefrontal-and-insular-tms-for-depression-in-schizophrenia-100597559",false,"NCT07060066","Bilateral Prefrontal and Insular TMS for Depression in Schizophrenia","Inclusion Criteria:\n\n* Male and female ages between ages 18-60 years.\n* Ability to give written informed consent (age 18 or above).\n* Diagnosed with schizophrenia-spectrum disorder and Evaluation to Sign Consent (ESC) above 10.\n* Score of Calgary depression scale for schizophrenia (CDSS) ≥ 3.\n\nExclusion Criteria:\n\n* Inability to sign informed consent.\n* Any major medical illnesses that may affect normal brain functioning. Examples of these conditions include, but are not limited to: stroke, repeated seizure, history of significant head trauma with cognitive sequela, CNS infection or tumor, other significant brain neurological conditions.\n* Significant alcohol or other drug use other than nicotine or marijuana dependence.\n* Inability to refrain from using alcohol and\u002For marijuana 24 hours or more prior to experiments.\n* Pregnancy, as classified by a woman of child-bearing potential who is not using a contraceptive and has missed a menstrual period; or by self-report; or by positive urine pregnancy test.\n* For MRI, inability to participate in the MRI scanning due to metallic devices or objects (cardiac pacemaker or neurostimulator, some artificial joints, metal pins, surgical clips or other implanted metal parts) or declining to get in the scanner.\n* Failed TMS safety questionnaire.","ALL","18 Years","60 Years",{"count":77,"type":78},120,"ESTIMATED","INTERVENTIONAL",[81],"NA","The purpose of this study is to provide an effective repetitive transcranial magnetic stimulation (rTMS) treatment for depressive symptoms in patients with schizophrenia. Schizophrenia patients with depressive symptoms will be exposed to rTMS to improve their symptoms.",[84],"Schizophrenia and Related Disorders",[86,87,88],"transcranial magnetic stimulation","schizophrenia","depression","2025-12-12",{"date":91,"type":92},"2025-12-17","ACTUAL",{"date":94,"type":92},"2024-05-21",{"date":96,"type":78},"2030-06-01",{"name":5,"class":6},1]